Results 91 to 100 of about 24,740 (199)
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Sleep disturbances are frequent symptoms of Alzheimer's disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative contributions of serotonin (5‐HT) and sex, has not been directly tested.
Louis J. Kolling +14 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle +7 more
wiley +1 more source
MedComm, Volume 7, Issue 8, August 2026.1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa +17 more
wiley +1 more source
Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy
Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley +1 more source
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis
The Journal of Pathology, Volume 269, Issue 4-5, Page 462-477, August 2026.Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) and the cannabinoid receptors CB1 and CB2 during AP.
Paula Goncalves‐Romeu +7 more
wiley +1 more source
Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
Sara M‐Alicante +6 more
wiley +1 more source
The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.CB1 and CB2 receptors are widely distributed in both normal and cancerous cells. Cannabinoids have a positive impact on reducing tumor growth in mice. A positive relationship exists between CB2 receptors and survival in skin melanoma. However, there is a negative impact on non‐small cell lung cancer and colon cancer, whereas a higher association of CB1
Farideh A. Javid +3 more
wiley +1 more source
Stress and Health, Volume 42, Issue 4, August 2026.ABSTRACT Exercise is suggested to help regulate emotions; however, its role in the underlying cognitive emotion regulation process—starting with a cue, cognitive actions to modify emotions, and desirable emotional changes—has not yet been demonstrated.
Juriena D. de Vries, Keri A. Pekaar
wiley +1 more source
Smart Medicine, Volume 5, Issue 4, August 2026.Adolescent omega‐3 polyunsaturated fatty acid supplementation enhances resilience to trauma in adulthood. DHA/EPA intake restores gut microbial balance, reprograms lipid metabolism, and normalizes prefrontal PI3K/AKT/mTOR signaling. These changes may collectively mitigate PTSD‐like fear memory and affective dysregulation. ABSTRACT Post‐traumatic stress
Wenjing Li +7 more
wiley +1 more source
Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 66, Issue 4, August 2026.ABSTRACT Background Endometriosis affects up to 10% of biological females of reproductive age. Current treatment options are limited and often unsuitable for prolonged use. Cannabis‐based medicinal products (CBMPs) have emerged as an alternative for pain management. Aims To analyse changes in patient‐reported outcome measures (PrOMs), prescribed opioid
Tania Ahmed +14 more
wiley +1 more source