Results 231 to 240 of about 36,731 (276)
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Česká gynekologie, 2021
Objective: Overview of current knowledge in the field of the endocannabinoid system with emphasis on the relationships between endocannabinoids and exocannabinoids. The endocannabinoid system consists of cannabinoid receptors 1 and 2, ligands of these receptors, especially two "classical" endocannabinoids N-arachidonoylethanolamine (anandamide) and 2 ...
Josef, Suchopár +4 more
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Objective: Overview of current knowledge in the field of the endocannabinoid system with emphasis on the relationships between endocannabinoids and exocannabinoids. The endocannabinoid system consists of cannabinoid receptors 1 and 2, ligands of these receptors, especially two "classical" endocannabinoids N-arachidonoylethanolamine (anandamide) and 2 ...
Josef, Suchopár +4 more
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European Journal of Pharmacology, 1998
The background knowledge leading to the isolation and identification of anandamide and 2-arachidonoyl glycerol, the principal endocannabinoids is described. The structure-activity relationships of these lipid derivatives are summarized. Selected biochemical and pharmacological topics in this field are discussed, the main ones being levels of ...
R, Mechoulam, E, Fride, V, Di Marzo
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The background knowledge leading to the isolation and identification of anandamide and 2-arachidonoyl glycerol, the principal endocannabinoids is described. The structure-activity relationships of these lipid derivatives are summarized. Selected biochemical and pharmacological topics in this field are discussed, the main ones being levels of ...
R, Mechoulam, E, Fride, V, Di Marzo
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From endocannabinoid profiling to ‘endocannabinoid therapeutics’
Current Opinion in Chemical Biology, 2009The discovery of the endocannabinoid signalling system, that is, of cannabinoid receptors, their endogenous ligands, known as endocannabinoids, and of endocannabinoid anabolic and catabolic enzymes, raised several questions regarding the physiopathological role of these mediators. Several of these questions were answered by investigating alterations in
Ligresti A, Petrosino S, Di Marzo V
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Prostaglandins & Other Lipid Mediators, 2002
Endocannabinoids (endogenous ligands of cannabinoid receptors) such as anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol (2-AG) are inactivated upon enzymatic hydrolysis. Recent progress in the enzymological and molecular biological studies on the 'endocannabinoid hydrolases' is reviewed in this article.
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Endocannabinoids (endogenous ligands of cannabinoid receptors) such as anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol (2-AG) are inactivated upon enzymatic hydrolysis. Recent progress in the enzymological and molecular biological studies on the 'endocannabinoid hydrolases' is reviewed in this article.
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European Journal of Lipid Science and Technology, 2006
The endocannabinoid system embraces a group of lipid molecules, enzymes and receptor proteins. This system appears to be involved in the modulation of neurotransmitter release thereby modifying learning and memory, in the regulation of food intake, and in the modulation of inflammation and pain and several other physiological/pathophysiological ...
Hansen, Harald S. +3 more
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The endocannabinoid system embraces a group of lipid molecules, enzymes and receptor proteins. This system appears to be involved in the modulation of neurotransmitter release thereby modifying learning and memory, in the regulation of food intake, and in the modulation of inflammation and pain and several other physiological/pathophysiological ...
Hansen, Harald S. +3 more
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Essays in Biochemistry, 2020
Abstract Thirty years ago, the discovery of a cannabinoid (CB) receptor that interacts with the psychoactive compound in Cannabis led to the identification of anandamide, an endogenous receptor ligand or endocannabinoid. Research on endocannabinoids has since exploded, and additional receptors along with their lipid mediators and ...
Aruna Kilaru, Kent D. Chapman
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Abstract Thirty years ago, the discovery of a cannabinoid (CB) receptor that interacts with the psychoactive compound in Cannabis led to the identification of anandamide, an endogenous receptor ligand or endocannabinoid. Research on endocannabinoids has since exploded, and additional receptors along with their lipid mediators and ...
Aruna Kilaru, Kent D. Chapman
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Endocannabinoid-Based Therapies
Annual Review of Pharmacology and Toxicology, 2022The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles in mammalian physiology. Dysfunctions in their activity have been implicated in various disease conditions, attracting attention to the endocannabinoid system as a possible source of therapeutic drugs.
Daniele, Piomelli, Alex, Mabou Tagne
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Endocannabinoids and Nutrition
Journal of Neuroendocrinology, 2008The endocannabinoids anandamide (AEA) and 2‐arachidonoylglycerol (2‐AG) are bioactive lipids derived from the n‐6 family of polyunsaturated fatty acids that are essential fatty acids. Symptoms of essential fatty acid deficiency in rats – growth retardation, scaly skin, and increased transepidermal water loss – can mainly be attributed to lack of ...
Hansen, Harald S., Artmann, Andreas
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Neuroscience & Biobehavioral Reviews, 2016
Sleep is regulated by several brain structures, neurotransmitters and neuromodulators. Endocannabinoids (eCBs) are a group of lipids with modulatory activity in the brain and bind mainly to cannabinoid receptors CB1R and CB2R, thereby modulating several brain functions, (memory, mood, food intake, pain perception).
Oscar, Prospéro-García +4 more
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Sleep is regulated by several brain structures, neurotransmitters and neuromodulators. Endocannabinoids (eCBs) are a group of lipids with modulatory activity in the brain and bind mainly to cannabinoid receptors CB1R and CB2R, thereby modulating several brain functions, (memory, mood, food intake, pain perception).
Oscar, Prospéro-García +4 more
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Endocannabinoids and Neuroprotection
Science Signaling, 2002Traumatic brain injury (TBI) releases harmful mediators that lead to secondary damage. On the other hand, neuroprotective mediators are also released, and the balance between these classes of mediators determines the final outcome after injury. Recently, it was shown that the endogenous brain cannabinoids anandamide and 2-Arachidonoyl glycerol (2-AG ...
R, Mechoulam, M, Spatz, E, Shohami
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