Results 1 to 10 of about 25,135 (155)
Development of the Endocardium [PDF]
Pediatric Cardiology, 2010 The endocardium, the endothelial lining of the heart, plays complex and critical roles in heart development, particularly in the formation of the cardiac valves and septa, the division of the truncus arteriosus into the aortic and pulmonary trunks, the development of Purkinje fibers that form the cardiac conduction system, and the formation of ...
Brian Black +2 more
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Reprogramming the Endocardium [PDF]
Circulation Research, 2018 Normal cardiac function is heavily dependent on effective coronary circulation. Coronary perfusion abnormalities, congenital or, much more commonly, acquired, are the leading cause of cardiovascular morbidity and mortality. Despite many advances in our understanding of fundamentals of heart and blood vessel biology, therapeutic options for patients ...
Dongying Chen, Michael Simons
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Animals, 2021 Aortic thromboembolism (ATE) occurs in cats with cardiomyopathy and often results in euthanasia due to poor prognosis. However, the underlying predisposing mechanisms leading to left atrial (LA) thrombus formation are not fully characterised.
Virginia Luis Fuentes +2 more
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Endocardium Contributes to Cardiac Fat [PDF]
Circulation Research, 2016 Rationale: Unraveling the developmental origin of cardiac fat could offer important implications for the treatment of cardiovascular disease. The recent identification of the mesothelial source of epicardial fat tissues reveals a heterogeneous origin of adipocytes in the adult heart.
Wenjuan Pu, Bin Zhou, Shengshou Hu
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ETS1 and HLHS: Implications for the Role of the Endocardium
Journal of Cardiovascular Development and Disease, 2022 We have identified the ETS1 gene as the cause of congenital heart defects, including an unprecedented high frequency of HLHS, in the chromosomal disorder Jacobsen syndrome. Studies in Ciona intestinalis demonstrated a critical role for ETS1 in heart cell
Paul Grossfeld
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Endocardium gives rise to blood cells in zebrafish embryos
Cell ReportsSummary: Previous studies have suggested that the endocardium contributes to hematopoiesis in murine embryos, although definitive evidence to demonstrate the hematopoietic potential of the endocardium is still missing.
Saulius Sumanas
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Endocardial Regulation of Cardiac Development
Journal of Cardiovascular Development and Disease, 2022 The endocardium is a specialized form of endothelium that lines the inner side of the heart chambers and plays a crucial role in cardiac development.
Lara Feulner +3 more
doaj +1 more source
Cell Reports, 2021 Summary: In the zebrafish embryo, the onset of blood flow generates fluid shear stress on endocardial cells, which are specialized endothelial cells that line the interior of the heart.
Alessio Paolini +4 more
doaj +1 more source
Dissecting the Complexity of Early Heart Progenitor Cells
Journal of Cardiovascular Development and Disease, 2021 Early heart development depends on the coordinated participation of heterogeneous cell sources. As pioneer work from Adriana C. Gittenberger-de Groot demonstrated, characterizing these distinct cell sources helps us to understand congenital heart defects.
Miquel Sendra +3 more
doaj +1 more source
The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration
Journal of Cardiovascular Development and Disease, 2021 In zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post-embryonic vascular development, the maintenance of vascular ...
Vanessa Lowe +2 more
doaj +1 more source