Results 11 to 20 of about 48,972 (257)

The Endocardium and Heart Valves

Cold Spring Harbor Perspectives in Biology, 2020
Endocardial cells are specialized endothelial cells that, during embryogenesis, form a lining on the inside of the developing heart, which is maintained throughout life. Endocardial cells are an essential source for several lineages of the cardiovascular system including coronary endothelium, endocardial cushion mesenchyme, cardiomyocytes, mural cells,
Bailey, Dye, Joy, Lincoln
openaire   +4 more sources

Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice

Scientific Reports, 2019
Abstract The endocardium is the endothelial component of the vertebrate heart and plays a key role in heart development. Where, when, and how the endocardium segregates during embryogenesis have remained largely unknown, however. We now show that Nkx2-5 +
Saba, R, Kitajima, K, Rainbow, L, Engert, S, Uemura, M, Ishida, H, Kokkinopoulos, I, Shintani, Y, Miyagawa, S, Kanai, Y, Kanai-Azuma, M, Koopman, P, Meno, C, Kenny, J, Lickert, H, Saga, Y, Suzuki, K, Sawa, Y, Yashiro, K   +18 more
openaire   +6 more sources

Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium

Cell Reports, 2014
The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during cardiac morphogenesis via expression and function within myocardial, neural crest, and epicardial cell populations.
Nathan J. VanDusen, Jose Casanovas, Joshua W. Vincentz, Beth A. Firulli, Marco Osterwalder, Javier Lopez-Rios, Rolf Zeller, Bin Zhou, Joaquim Grego-Bessa, José Luis De La Pompa, Weinian Shou, Anthony B. Firulli   +11 more
doaj   +2 more sources

Transcatheter Myotomy to Relieve Left Ventricular Outflow Tract Obstruction: The Septal Scoring Along the Midline Endocardium Procedure in Animals

Circulation. Cardiovascular Interventions, 2022
Background: Left ventricular outflow tract obstruction complicates hypertrophic cardiomyopathy and transcatheter mitral valve replacement. Septal reduction therapies including surgical myectomy and alcohol septal ablation are limited by surgical ...
Jaffar M. Khan, Christopher G. Bruce, A. Greenbaum, V. Babaliaros, Andrea E Jaimes, W. Schenke, R. Ramasawmy, F. Seemann, D. Herzka, T. Rogers, M. A. Eckhaus, A. Campbell-Washburn, R. Guyton, R. Lederman   +13 more
semanticscholar   +1 more source

GATA4 Regulates Developing Endocardium Through Interaction With ETS1

Circulation Research, 2022
Background: The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development.
P. Zhou, Yan Zhang, Isha Sethi, L. Ye, M. Trembley, Yangpo Cao, Brynn N. Akerberg, Feng Xiao, Xiaoran Zhang, Kai Li, Blake D. Jardin, Neil Mazumdar, Qing Ma, Aibin He, B. Zhou, W. Pu   +15 more
semanticscholar   +1 more source

VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration.

Circulation, 2020
Background: Recent discoveries have indicated that, in the developing heart, sinus venosus and endocardium provide major sources of endothelium for coronary vessel growth that supports the expanding myocardium.
Markus Räsänen, Ibrahim Sultan, Jennifer Paech, K. A. Hemanthakumar, Wei Yu, Liqun He, Juan Tang, Ying Sun, R. Hlushchuk, Xiuzheng Huan, Emma Armstrong, O. Khoma, E. Mervaala, V. Djonov, C. Betsholtz, Bin Zhou, R. Kivelä, K. Alitalo   +17 more
semanticscholar   +1 more source

The Zebrafish Cardiac Endothelial Cell—Roles in Development and Regeneration

Journal of Cardiovascular Development and Disease, 2021
In zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post-embryonic vascular development, the maintenance of vascular ...
Vanessa Lowe, Laura Wisniewski, Caroline Pellet-Many   +2 more
doaj   +1 more source

Inadvertent Diversion of Superior Vena Cava to the Left Atrium- A Diagnosis Made by Bubble Contrast Echocardiography [PDF]

Journal of Clinical and Diagnostic Research, 2018
Sinus venosus Atrial Septal Defect (ASD) is the abnormal drainage of pulmonary veins to right atrium, which can present with symptoms of pulmonary hypertension.
Mahendra Tilkar, Agam Bansal
doaj   +1 more source

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Endocardial cells are a major progenitor population that gives rise to heart valves through endocardial cushion formation by endocardial to mesenchymal transformation and the subsequent endocardial cushion remodeling.
Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, Bin Zhou   +8 more
doaj   +1 more source

Immunohistological Evaluation of Von Willebrand Factor in the Left Atrial Endocardium and Atrial Thrombi from Cats with Cardiomyopathy

Animals, 2021
Aortic thromboembolism (ATE) occurs in cats with cardiomyopathy and often results in euthanasia due to poor prognosis. However, the underlying predisposing mechanisms leading to left atrial (LA) thrombus formation are not fully characterised.
Wan-Ching Cheng, Lois Wilkie, Tsumugi Anne Kurosawa, Melanie Dobromylskyj, Simon Lawrence Priestnall, Virginia Luis Fuentes, David J. Connolly   +6 more
doaj   +1 more source