Annals of Gastroenterological Surgery, EarlyView.This nationwide claims‐based study analyzed recent trends in pancreatic cancer incidence (2016–2021) and surgery (2016–2023) in Japan. The study revealed a rising incidence of pancreatic cancer, notably among young women, and an increasing use of distal pancreatectomy among older adults.
Masamitsu Kido +10 more
wiley +1 more source
Prenatal exposure to endocrine-disrupting chemicals and childhood atopic dermatitis: epidemiological evidence. [PDF]
Front MicrobiolChen Y, Zhang L, Yang T, Chen L.
europepmc +1 more source
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, EarlyView.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source
Exploratory identification of COL1A1 as a potential gene linking endocrine-disrupting chemicals and lung adenocarcinoma: a bioinformatics and machine learning analysis. [PDF]
BMC Pharmacol ToxicolShe T, Sun F, Xie Z, Cao Y, Xu H.
europepmc +1 more source
Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, EarlyView.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
Editorial: Xenosensors as the targets of endocrine-disrupting chemicals. [PDF]
Front Endocrinol (Lausanne)Ghassemi-Barghi N, Khan F, Bayrami Z.
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.In the compression suture group, a 5‐mm‐wide tail skin was removed, and then the defect was sutured to apply compressive force to the intervertebral disc. In the sham group, only the 5‐mm‐wide tail skin was removed without a compression suture. Compression suturing triggers apoptosis, inflammatory response, and imbalance of extracellular matrix ...
Xuening Liu +4 more
wiley +1 more source
QuEChERS analytical approach for monitoring endocrine-disrupting chemicals in human urine. [PDF]
Anal Bioanal ChemCallejas-Martos S, Eljarrat E.
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong +5 more
wiley +1 more source
Development and validation of a novel senescence-associated gene signature for prediction of survival and endocrine-disrupting chemicals in bladder cancer. [PDF]
Discov OncolQin M +8 more
europepmc +1 more source