Results 91 to 100 of about 858,546 (315)

Forecasting Death Trend of Endocrine, Nutritional, and Metabolic Diseases in Iran during 2006 to 2035

مجله اپیدمیولوژی ایران, 2018
Background and Objectives: Among non-communicable diseases, endocrine, nutritional, and metabolic diseases have increased in recent decades, especially in developing countries.
S Aghamohamadi, , , ,
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (Danio rerio)

Toxics
Chiral pesticides exhibit enantioselective differences in processes such as biological absorption, metabolism, and toxic effects. Organisms have different physiological characteristics at different developmental stages. Therefore, conducting enantiomeric
Jiqin Feng, Xintong Xu, Wenfei Huang, Honghong Gong, Xiaohui Sun, Jinsong Liu, Chao Xu, Weiping Liu   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Overview of air pollution and endocrine disorders [PDF]

, 2018
Philippa D Darbre School of Biological Sciences, University of Reading, Reading, UK Abstract: Over recent years, many environmental pollutant chemicals have been shown to possess the ability to interfere in the functioning of the endocrine system and ...
Darbre PD, Philippa Darbre, Darbre, Philippa D.   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Large Retrosternal Parathyroid Carcinoma with Primary Hyperparathyroidism

Asian Journal of Surgery, 2007
Parathyroid carcinoma is an uncommon cause of parathyroid hormone (PTH)-dependent hypercalcaemia, accounting for less than 1% of all cases of hyperparathyroidism.
Geok Chin Tan, M. Sidik Shiran, Manickam Swaminathan, K. Seng Phang, Muhammad Rohaizak   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Unveiling the Interplay—Vitamin D and ACE-2 Molecular Interactions in Mitigating Complications and Deaths from SARS-CoV-2

Biology
The interaction of the SARS-CoV-2 spike protein with membrane-bound angiotensin-converting enzyme-2 (ACE-2) receptors in epithelial cells facilitates viral entry into human cells.
Sunil J. Wimalawansa
doaj   +1 more source

Endocrine Entropy

Journal of the Pakistan Medical Association
This communication defines and describes the novelconcept of endocrine entropy. The authors share insightsregarding the various facets of entropy in endocrineepidemiology, physiology, clinical presentation andmanagement. The discussion opens up a new way ofapproaching endocrinology. Recent advances in artificialintelligence, assessment and addressal of
Sanjay Kalra, Nitin Kapoor
openaire   +4 more sources