Results 111 to 120 of about 858,546 (315)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

In vitro endocrine activity of mycotoxins and their mixtures.

, 2015
A lot of substances in food and feed can interfere with the hormonal system of humans and animals by influencing the synthesis, metabolism or transport of hormones; or by interacting directly with the hormone receptor (as an agonist or antagonist).
L. Pussemier, A. Evrard, K. Vandermeiren, A. Callebaut, H. Demaegdt   +4 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Recombinant growth hormone therapy in children with short stature in Abu Dhabi: a cross-sectional study of indications and treatment outcomes

Frontiers in Pediatrics
Early diagnosis of the pathological cause, if any, of short stature in children can lead to prompt intervention with recombinant growth hormone (rGH) treatment, potentially allowing them to achieve their true genetic height potential.
Sara Salem Al Jneibi, Fatima Taha, Marwa Hammouri, Zahraa Allami, Stefan Weber, Jamal Aljubeh, Sareea Al Remeithi   +6 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Developing a machine learning-based predictive model for levothyroxine dosage estimation in hypothyroid patients: a retrospective study

Frontiers in Endocrinology
Hypothyroidism, a common endocrine disorder, has a high incidence in women and increases with age. Levothyroxine (LT4) is the standard therapy; however, achieving clinical and biochemical euthyroidism is challenging.
Tran Thi Ngan, Tran Thi Ngan, Dang Huong Tra, Ngo Thi Quynh Mai, Hoang Van Dung, Nguyen Van Khai, Pham Van Linh, Nguyen Thi Thu Phuong, Nguyen Thi Thu Phuong   +8 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

COMPRENDO: Focus and approach

, 2006
Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife.
Wollenberger, L, Axel Allera, Vasilis Sakkas, Ronny van Aerle, Ballegoy, C., Gemma Janer, van Ballegoy, C, Sakkas, V., A. Allera, Isabella King, J. Falandysz, Christoph van Ballegoy, S. Galassi, Nicola Beresford, Aerle, R., Beresford, Nicola, K. O. Kusk, Hala, David, Janer, G, Kloas, W., Triantafyllos Albanis, Kusk, Kresten, Ole, Hala, D, F. Ciceri, Oredsson, Stina, Kusk, Kresten,, Oredsson, S., van Aerle, R., Galassi, S, Dagnac, T., Falandysz, Jerzy, Lo, S., Lutz, Ilka, Kingmüller, D., Werner Kloas, Albanis, T, Lutz, I., Stina Oredsson, Albanis, Triantafyllos, Klingmüller, Dietrich, van Ballegoy, C., Lund University., Wollenberger, L., Carnevali, Daniela, Candia, Carnevali, M. Daniela Candia, Susan Jobling, Levada, R, Kusk, Kresten Ole, Jobling, S., Oehlmann, Jörg, Ciceri, F, Jean Bachmann, M.D. Candia Carnevali, U. Schulte Oehlmann, Kusk, KO, Rand-Weaver, M., Lavado Parra, Ramón, Klingmüller, D., Schulte-Oehlmann, U., N. Beresford, Dagnac, T, D. Klingmüller, Aerle, Ronny van, Hala, D., King, I., P. Berntsson, Bachmann, J., R. Jeannot, Carnevali, Daniela Candia, Levada, R., Allera, A, Bachmann, J, Allera, A., Charles Tyler, Porte, C., Schulte-Oehlmann, Ulrike, Sakkas, Vasilis, Oredsson, Stina,, Sugni, M, Tyler, Charles R., Sakkas, M, Jeannot, R., Pia Berntsson, Marian Rand-Weaver, Ballegoy, Christoph van, Berntsson, P, Galassi, S., Kresten Ole Kusk, T. Albanis, Falandysz, J., Jörg Oehlmann, M SUGNI, R. Levada, Lutz, I, Falandysz, J, Porte, C, Ciceri, F., Janer, G., David Hala, Beresford, NA, Oredsson, S, Tyler, C., Kloas, W, Allera, Axel, T. Dagnac, Berntsson, Pia, Janer, Gemma, Schulte-Oehlmann, U, Michela Sugni, Carnevali, Daniela,, Tyler, C, Klingmüller, D, Beresford, N., Sakkas, V, Galassi, Silvana, Daniela Candia Carnevali, Francesca Ciceri, Dietrich Klingmüller, Lo, S, Beresford, N, Dagnac, Thierry, W. Kloas, Cinta Porte, Berntsson, Pia,, Albanis, T., Jobling, S, Jobling, Susan, King, Isabella, Van Aerle, Ronny, Kloas, Werner, Lo, Susan, Roger Jeannot, Wollenberger, Leah, D. Hala, Thierry Dagnac, Jerzy Falandysz, Oehlmann, J., J. Bachmann, Ulrike Schulte-Oehlmann, Bachmann, Jean, Sugni, M., Leah Wollenberger, Ramon Levada, Carnivali, D.C., Tyler, Charles, Berntsson, P., Silvana Galassi, S. Jobling, King, I, Sugni, Michela, Susan Lo, van Aerle, R, Ciceri, Francesca, Porte Visa, Cinta, G. Janer, Carnevali, DC, Rand-Weaver, Marian, Carnevali, D. C., Van Ballegoy, Christoph, Oehlmann, J, Levada, Ramon, Jeannot, Roger, Jeannot, R, Porte, Cinta, Kusk, K. O., Rand-Weaver, M, Ilka Lutz, I. King   +167 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source