Results 61 to 70 of about 858,546 (315)

MYELOLIPOMA IN THE ADRENAL GLAND OF A CANINE

UNINGÁ Review, 2020
The present report aims to describe the macroscopic and histopathological findings of a canine with myelolipoma in the left adrenal gland.
Monique Togni, Joana Cristina Smaha de Jesus Lima, Maisa Martins Quirilos Assis, Willian Fontini Marangon, Jean Carlos Luz   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The effects of bed rest and countermeasure exercise on the endocrine system in male adults: Evidence for immobilization-induced reduction in sex hormone-binding globulin levels [PDF]

, 2012
Background and Aim. There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56-day) bed-rest in male ...
Rittweger, Jörn, Roth, H.J., Armbrecht, Gabriele, Felsenberg, Dieter, Seibel, Markus, Belavy, Daniel Ludovic   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A retrospective analysis of endocrine disease in sphingosine-1-phosphate lyase insufficiency: case series and literature review

, 2022
Sphingosine-1-phosphate lyase (SGPL1) insufficiency syndrome (SPLIS) is an autosomal recessive multi-system disorder, which mainly incorporates steroid-resistant nephrotic syndrome and primary adrenal insufficiency.
GÜRAN, TÜLAY
core   +1 more source

Androgenic Steroid Hormones and Endurance Exercise in Athletic Women

Endocrines
This study investigated the impact of intensive endurance exercise on circulating androgenic steroid hormones in women. Fifteen normally menstruating athletic women participated.
Anthony C. Hackney, Raul Cosme Ramos Prado, Eimear Dolan   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Multiple Endocrine Neoplasia Type 1 (MEN1): Loss of One MEN1 Allele in Tumors and Monohormonal Endocrine Cell Clusters But Not in Islet Hyperplasia of the Pancreas

, 2006
CONTEXT: The occurrence of multiple small pancreatic endocrine tumors in patients suffering from multiple endocrine neoplasia type 1 (MEN1) represents a unique possibility to study early neoplasms and their potential precursor lesions.
Thomas Rudolph, Paul Komminoth, Dralle, Henning, Gimm, Oliver, Eberhard Weihe, Komminoth, Paul,, Weihe, Eberhard, Tobias Henopp, Anlauf, Martin,, Gimm, Oliver,, Heitz, Philipp U,, Rudolph, Thomas, Klöppel, Günter,, Wolfram T. Knoefel, Dralle, Henning,, Perren, Aurel,, Raffel, Andreas,, Weihe, Eberhard,, Henopp, Tobias, Heitz, Philipp U., Andreas Raffel, Knoefel, Wolfram T,, Anlauf, Martin, Aurel Perren, Rudolph, Thomas,, Knoefel, Wolfram T., Perren, Aurel, Schmitt, Anja,, Komminoth, Paul, Martin Anlauf, Anja Schmitt, Oliver Gimm, Philipp U. Heitz, Henopp, Tobias,, Günter Klöppel, Klöppel, Günter, Schmitt, Anja, Henning Dralle, Raffel, Andreas   +38 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source