Results 1 to 10 of about 3,197,524 (305)

Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study

BMC Medicine
Background Birthweight readily measurable marker of fetal growth that may influence health across the lifespan. We aimed to investigate the potential causal association between birthweight and healthy aging and to identify the mediating roles of ...
Lijie Kong, Chun Dou, Chaojie Ye, Dong Liu, Mingling Chen, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Ruixin Liu, Tiange Wang   +16 more
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禁食和再进食触发胆汁酸谱和肠道微生物群的特异性变化

Journal of Diabetes, 2023
Background Bile acids (BAs) are closely related to nutrient supply and modified by gut microbiota. Gut microbiota perturbations shape BA composition, which further affects host metabolism.
Yi Zhang, Hongyan Qi, Long Wang, Chunyan Hu, Aibo Gao, Qihan Wu, Qiaoling Wang, Huibin Lin, Banru Chen, Xingyu Wang, Shuangyuan Wang, Hong Lin, Weiqing Wang, Yufang Bi, Jiqiu Wang, Jieli Lu, Ruixin Liu   +16 more
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非酒精性脂肪性肝病与血糖的缓解和进展

Journal of Diabetes, 2022
Background The study aimed to explore the associations of nonalcoholic fatty liver disease (NAFLD) with the remission and progression along the glycemic continuum.
Zhuojun Xin, Jiaojiao Huang, Qiuyu Cao, Jialu Wang, Ruixin He, Tianzhichao Hou, Yi Ding, Jieli Lu, Min Xu, Tiange Wang, Zhiyun Zhao, Weiqing Wang, Guang Ning, Yufang Bi, Yu Xu, Mian Li   +15 more
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The Effect of Canagliflozin on High-Density Lipoprotein Cholesterol and Angiopoietin-Like Protein 3 in Type 2 Diabetes Mellitus

Journal of Diabetes Research
Background. Diabetes mellitus is often accompanied by dyslipidemia. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, as a novel therapeutic agent for the treatment of type 2 diabetes mellitus (T2DM), have been reported to exert effects on lipid, while ...
Simo Liu, Jing Ke, Xiaotong Feng, Zongwei Wang, Xin Wang, Longyan Yang, Dong Zhao   +6 more
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Discordance between the triglyceride glucose index and HOMA-IR in incident albuminuria: a cohort study from China

Lipids in Health and Disease, 2021
Background To date, there have no study comparing the associations between TyG index and HOMA-IR on the risk of incident albuminuria. Accordingly, the objective of the present study is to use discordance analysis to evaluate the diverse associations ...
Wei Gao, Jialu Wang, Yan Chen, Hongmei Qiao, Xiaozhong Qian, Zhuojun Xin, Zhiyun Zhao, Tiange Wang, Yu Xu, Min Xu, Yufang Bi, Mian Li, Jinli Gao   +12 more
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Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function

Translational Psychiatry
Epidemiological studies suggested an association between omega-3 fatty acids and cognitive function. However, the causal role of the fatty acid desaturase (FADS) gene, which play a key role in regulating omega-3 fatty acids biosynthesis, on cognitive ...
Xueyan Wu, Lei Jiang, Hongyan Qi, Chunyan Hu, Xiaojing Jia, Hong Lin, Shuangyuan Wang, Lin Lin, Yifang Zhang, Ruizhi Zheng, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Yuhong Chen, Jie Zheng, Yufang Bi, Jieli Lu   +18 more
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Genetic susceptibility, family history of diabetes and healthy lifestyle factors in relation to diabetes: A gene–environment interaction analysis in Chinese adults

Journal of Diabetes Investigation, 2021
Aims/Introduction To analyze the associations and interactions of the genetic susceptibility and family history of diabetes with lifestyle factors in relation to diabetes among Chinese adults.
Chaojie Ye, Jingya Niu, Zhiyun Zhao, Mian Li, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Min Xu, Tiange Wang   +11 more
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Changes in frailty, intensive blood pressure treatment, and risks of adverse clinical outcomes: a post hoc analysis of the SPRINT trial

BMC Medicine
Background Frailty is becoming a common health issue and its status changes overtime. However, the impact of the frailty status changes on clinical outcomes is unknown.
Xiaoyun Zhang, Xi Meng, Siyu Wang, Qing Lin, Yueyue Wang, Yu Xiang, Kan Wang, Xuan Zhao, Mian Li, Tiange Wang, Zhiyun Zhao, Jieli Lu, Min Xu, Jie Zheng, Yufang Bi, Yu Xu   +15 more
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Clinical subgroup-stratified plasma proteomic signatures improve risk prediction for myocardial infarction: SCORE2-Pro

Cardiovascular Diabetology
Background Myocardial infarction (MI) remains a leading cause of global mortality, with risk varying substantially across demographic and clinical subgroups.
Muye Tong, Minchun Zhang, Min Xu, Zhiwen Cao, Guang Ning, Weiqing Wang, Jiqiu Wang, Qian Yang, Jie Zheng   +8 more
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Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health

Nature Communications
Limited identification of insulin resistance-associated loci hinders understanding of its role in cardiometabolic health, impeding therapeutic strategies.
Chaojie Ye, Chun Dou, Dong Liu, Lijie Kong, Mingling Chen, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jie Zheng, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Tiange Wang   +15 more
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