Results 61 to 70 of about 36,937 (249)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Current evidence for the roles of early-life endocrine disruptors on pubertal timing in girls [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2019
Over the last decades, the onset of puberty in girls has occurred earlier, but the tempo of pubertal progression has been relatively slower, resulting in a younger age at puberty onset without a change in age at menarche.
Jeong Eun Lee, Hae Woon Jung, Yun Jeong Lee, Young Ah Lee   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Relationship Between Maternal Exposure to Endocrine-Disrupting Chemicals and the Incidence of Congenital Heart Diseases: A Systematic Review and Meta-Analysis

Metabolites
Background: Congenital heart diseases are among the most common birth defects, significantly impacting infant health. Recent evidence suggests that exposure to endocrine-disrupting chemicals may contribute to the incidence of congenital heart diseases ...
Yasir Hassan Elhassan, Fahad Alahmadi, Emad Ali Albadawi, Abdullah Albarakati, Azizah Hendi Aljohany, Naweed SyedKhaleel Alzaman, Muayad Albadrani   +6 more
doaj   +1 more source

Silent Spring - the lost call [PDF]

, 2008
The "silence" in Rachel Carson's Silent Spring1 alludes to the demise of bird populations through reproductive problems and death resulting from exposure to the pesticides of that time, many of which are endocrine active.
Mary Ann Ottinger, Michael J. Quinn
core   +1 more source

Treatment and removal strategies for estrogens from wastewater [PDF]

, 2008
Natural and synthetic steroidal estrogens (estrone, 17β-estradiol and 17α-ethinylestradiol) are endocrine disrupters, that are discharged consistently from the sewage treatment works into surface waters, thereby causing endocrine disrupting effects to ...
Boobis, AR, Cartmell, E, Chiu, TY, Koh, YKK, Lester, JN, Scrimshaw, MD   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Removal of endocrine disrupting chemicals using low pressure reverse osmosis membrane [PDF]

, 2009
Endocrine disrupting chemicals (EDCs) are one of the major focuses of contaminants in current environmental issues, as they can cause adverse health effects on animals and human, particularly to endocrine function.
Abd. Razak, Azri Rasyidi
core  

The impact of process variables on the removal of PBDEs and NPEOs during simulated activated sludge treatment [PDF]

, 2007
Sewage effluent is known to be a major source of endocrine disrupting compounds entering the aquatic environment. More efficient wastewater treatment could reduce the environmental load but, in order to achieve this factors determining compound behaviour
Langford, KH, Lester, JN, Scrimshaw, MD
core   +1 more source

Endocrine disrupting chemicals and adrenal gland​

Turkish Journal of Medical Sciences
Endocrine disrupting chemicals (EDCs) are exogenous compounds that have hormone-like effects inside the body. Endocrine disruptors can affect adrenal glands in humans and animals. Adrenocortical dysfunction related to chemical exposure has been reported in the literature.
ŞİMŞEK BAĞIR, Gülay, ERTÖRER, Melek Eda   +1 more
openaire   +2 more sources