Results 81 to 90 of about 36,937 (249)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Chemicals That Disrupt the Endocrine System and Their Effects on Behavior

Kashmir Journal of Science
Endocrine glands are the important glands of humans that perform certain functions and has specific characteristics. The main function of these glands is that they regulate the whole system by producing hormones which they produce indigenously and pour ...
Yousaf Khan1, Abdul Sattar1, Syed Amin Ullah1, Zia-Ur-Rehman2, Hakimullah3, Madeeha Bibi4, Hina Sarfraz1, Anila Mukhtiar1
doaj   +2 more sources

The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies [PDF]

, 2018
Mycotoxins are secondary metabolites produced by fungi that may contaminate different foods intended for human consumption, resulting in a widespread exposure worldwide. The novel exposome paradigm has the ambition to decipher the different environmental
Cano Sancho, German, Marín Sillué, Sònia, Ramos Girona, Antonio J., Sanchís Almenar, Vicente   +3 more
core   +4 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system [PDF]

, 2015
Endocrine disrupting chemicals (EDCs) are identified for their ability to perturb the homeostasis of endocrine system and hormonal balance. The male reproductive system is under close control of hormones and each change in their concentration and time of
DE FALCO, MARIA, FORTE, MAURIZIO, LAFORGIA, VINCENZA   +2 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Trends in reproductive health in Israel: implications for environmental health policy

Israel Journal of Health Policy Research, 2012
Nearly two decades ago, researchers first reported that endocrine disrupting chemicals in the environment were affecting reproductive health in the general population.
Berman Tamar, Levine Hagai, Gamzu Ronni, Grotto Itamar   +3 more
doaj   +1 more source

Nonylphenol and octylphenol differently affect cell redox balance by modulating the nitric oxide signaling [PDF]

, 2018
Nonylphenol (NP) and octylphenol (OP) are pervasive environmental contaminants belonging to the broader class of compounds known as alkylphenols, with potential human toxic effects.
Arese, Marzia, Magnifico, MARIA CHIARA, Popov, Milica, Sarti, Paolo, Saso, Luciano, Xhani, Marla   +5 more
core   +3 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Endocrine disrupting chemicals: gestational diabetes and beyond

Diabetology & Metabolic Syndrome
Gestational Diabetes Mellitus (GDM) has been on the rise for the last two decades along with the growing incidence of obesity. The ubiquitous use of Endocrine-Disrupting Chemicals (EDCs) worldwide has been associated with this increase in GDM incidence ...
Tridip Mitra, Richa Gulati, Krithika Ramachandran, Rohan Rajiv, Elizabeth Ann L. Enninga, Chris K Pierret, Sajeetha Kumari R, Rajiv Janardhanan   +7 more
doaj   +1 more source