Results 51 to 60 of about 36,937 (249)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The influence of endocrine disrupting chemicals

Quality in Sport
On a daily basis, everyone is exposed to many chemical compounds that have been classified as endocrine disrupting chemicals (EDCs). These are natural and artificially produced substances that are widely available in the environment today. The aim of the
Bartosz Pawłowski, Michał Sienkiewicz, Magdalena Kłusek , Dorota Zatłoka-Mazur, Monika Żybowska-Męczyńska, Filip Klimas, Bartłomiej Sienkiewicz, Kacper Rusiński, Adriana Potoczek   +8 more
doaj   +1 more source

Bioaugmentation mitigates the impact of estrogen on coliform-grazing protozoa in slow sand filters [PDF]

, 2016
Exposure to endocrine-disrupting chemicals (EDCs), such as estrogens, is a growing issue for human and animal health as they have been shown to cause reproductive and developmental abnormalities in wildlife and plants and have been linked to male ...
Collins, Gavin, Gauchotte-Lindsay, Caroline, Haig, Sarah-Jane, Quince, Christopher   +3 more
core   +10 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Development and validation of a survey on reproductive health behaviors to reduce exposure to endocrine-disrupting chemicals in Koreans

Frontiers in Reproductive Health
IntroductionRecently, issues related to climate change and endocrine-disrupting chemicals have come to the forefront. In particular, the pursuit of convenience has led to increased exposure to endocrine-disrupting chemicals in daily life, posing threats ...
Hye Jin Kim, Sung Hae Kim, So Young Choi, Gisoo Shin   +3 more
doaj   +1 more source

Association of phthalate exposure with thyroid function during pregnancy

Environment International, 2021
Background: The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear. Aim: To investigate the association of maternal urinary phthalates with markers of the thyroid system during early pregnancy.
Arash Derakhshan, Huan Shu, Maarten A.C. Broeren, Christian H. Lindh, Robin P. Peeters, Andreas Kortenkamp, Barbara Demeneix, Carl-Gustaf Bornehag, Tim I.M. Korevaar   +8 more
doaj   +1 more source

A critical review of the formation of mono- and dicarboxylated metabolic intermediates of alkylphenol polyethoxylates during wastewater treatment and their environmental significance [PDF]

, 2010
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Taylor & Francis.Alkylphenoxyacetic acids, the metabolic biodegradation products of alkylphenol ethoxylates, are commonly found in ...
AEA Technology Environment, Ahel M., Ahel M., Ahel M., APE Research Council, Ashfield L. A., Ball H. A., Barber L. B., Bennie T. D., Bennie T. D., Birkett J. W., Cefic, Cheng C. Y., Comber M. H. I., DiCorcia A., DiCorcia A., DiCorcia A., DiCorcia A., Ding W. H., Ding W. H., Duarte C. L., Dutta A. P., E. Cartmell, Environment Canada and Health Canada, European Commission, European Commission, European Commission, European Commission, Ferguson P. L., Ferguson P. L., Ferguson P. L., Field J. A., Fujii K., Fujita M., Garcia-Reyero N., Gehringer P., Gibson R., Giger W., Giger W., Gray M. A., Gutsche C. D., Haag W. R., Hayashi S., Hill W. J., Hoai P. M., Ike M., Isobe T., Ito Y., J. N. Lester, John D. M., Kinae N., Knepper T. P., Koh Y. K. K., Komori K., Langford K. H., Lee H. B., Lee H. B., Lester J. N., Liu X., M. D. Scrimshaw, Maeda S., Maki H., Maki H., Mann A. H., Mansour M., Manzano M. A., Maruyama K., Mayer T., Minamiyama M., Moraes M. C. F., N. Paterakis, Nguyen M. H., Nimrod A. C., Organisation for Economic Co-operation and Development, Petrovic M., Petrovic M., Petrovic M., Purdom C. E., Reinhard M., Schroder H. F., Servos M. R., Sheahan D., Staples C. A., Stiff M. J., Sumpter J. P., Szymanski A., Szymanski A., T. Y. Chiu, Tanghe T., Tarrant H., Terzic S., Ushida Y., Ventura F., Wagener S., Water Technology International Corporation, Zhang J.   +95 more
core   +1 more source

Endocrine-Disrupting Chemicals and Disease Endpoints

International Journal of Molecular Sciences, 2023
Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, and have been shown to interfere with physiological systems, especially by disrupting the hormone balance. During the last few decades, EDCs have been shown to affect reproductive, neurological, and metabolic development and function and even stimulate tumor growth ...
Changhwan Ahn, Eui-Bae Jeung
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Is there a causal association between genotoxicity and the imposex effect? [PDF]

, 2006
There is a growing body of evidence that indicates common environmental pollutants are capable of disrupting reproductive and developmental processes by interfering with the actions of endogenous hormones.
Josephine A. Hagger, Michael H. Depledge, Jörg Oehlmann, Susan Jobling, Tamara S. Galloway, Colborn T, Collins MKL, Cooke H, Depledge MH, Gibbs PE, Harring KE, Harris JO, Laruelle F, Smith BS   +13 more
core   +1 more source