Results 71 to 80 of about 174,481 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Endocrine disruption [PDF]

Journal of Epidemiology and Community Health, 2007
Nicolas, Olea, Marieta, Fernández
openaire   +4 more sources

The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals

Frontiers in Endocrinology
Congenital cryptorchidism, also known as undescended testis, is the condition where one or both testes are not in place in the scrotum at birth and is one of the most common birth defects in boys.
Stine A. Holmboe, Stine A. Holmboe, Astrid L. Beck, Astrid L. Beck, Anna-Maria Andersson, Anna-Maria Andersson, Katharina M. Main, Katharina M. Main, Katharina M. Main, Niels Jørgensen, Niels Jørgensen, Niels E. Skakkebæk, Niels E. Skakkebæk, Niels E. Skakkebæk, Lærke Priskorn, Lærke Priskorn   +15 more
doaj   +1 more source

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs [PDF]

, 2015
Bisphenol A (BPA) and diethylstilbestrol (DES) are xenoestrogens which have been associated with altered effects on reproduction. We hypothesized that neonatal xenoestrogen exposure affects the ovarian functionality in lambs.
Belmonte, Norberto Miguel, Bosquiazzo, Veronica Lis, Luque, Enrique Hugo, Muñoz de Toro, Monica Milagros, Osti, Mario, Rivera, Oscar E., Rodriguez, Horacio Adolfo, Santamaría, Clarisa Guillermina, Varayoud, Jorgelina Guadalupe   +8 more
core   +2 more sources

Placenta Disrupted: Endocrine Disrupting Chemicals and Pregnancy

Trends in Endocrinology & Metabolism, 2020
Endocrine disrupting chemicals (EDCs) are chemicals that can interfere with normal endocrine signals. Human exposure to EDCs is particularly concerning during vulnerable periods of life, such as pregnancy. However, often overlooked is the effect that EDCs may pose to the placenta.
Jeremy Gingrich, Elvis Ticiani, Almudena Veiga-Lopez   +2 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Relations of environmental contaminants, algal toxins, and diet with the reproductive success of American alligators on Florida Lakes [PDF]

, 2001
(113 page ...
Arnold, Beverly S., Gross, Timothy S., McDonald, Kelly, Spulveda, Maria S.   +3 more
core  

Disrupción endocrina e imposex [PDF]

, 2007
From the injurious effects generate by the pollutants, Endocrine Disruption (ED) constitute one of the worrying cases, since it affects directly the individuals exposed to the substances that act like disruptors, as indirectly causing effects in the ...
Chacón, Óscar, Cuevas, Fabrizio, De La Fuente, Christian, Díaz, Fabián, Huaquín, Laura   +4 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

In vitro embryogenesis of Neomysis integer (Crustacea, Mysidacea) as a potential indicator of endocrine disruption [PDF]

, 2005
The brackish water mysid Neomysis integer has been put forward to use as a test organisms for the evaluation of environmental endocrine disruption in the brackish reaches of Western European estuaries and inland water bodies. As the embryonic development
Bruwiere, S., Fockedey, N., Ghekiere, A., Vincx, M.   +3 more
core