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Exocrine and endocrine insufficiencies are frequent complications of surgical treatment for pancreatic diseases. The presence and extent of the insufficiency depend on the underlying disorder, type of surgical procedure, extent of pancreatic ...
D. S. Bordin +5 more
doaj +1 more source
Chronic pancreatitis is a syndrome involving inflammation, fibrosis, and loss of acinar and islet cells which can manifest in unrelenting abdominal pain, malnutrition, and exocrine and endocrine insufficiency.
Angela Pham, Christopher Forsmark
doaj +1 more source
Congenital pancreatic hypoplasia: A syndrome of exocrine and endocrine pancreatic insufficiency
We describe two brothers with small size at birth, early-onset insulin-dependent diabetes, and pancreatic exocrine insufficiency. In contrast to the findings in pancreatic aplasia, their serum C-peptide and glucagon levels were measurable. These findings, in concert with their clinical courses, are consistent with the diagnosis of congenital pancreatic
Department of Pathology, University of Florida, Gainesville USA ( host institution ) +6 more
openaire +3 more sources
EXOCRINE AND ENDOCRINE PANCREATIC INSUFFICIENCY IN DEVELOPMENT OF ATHEROSCLEROSIS
Objective: To evaluate the effect of chronic pancreatitis (CP) and exocrine insufficiency of the pancreas on the carotid intima media thickness (cIMT) in patients with type 2 diabetes mellitus (DM-2). Materials and methods: 91 patients were examined, they were divided into groups: 1st group-patients with DM-2 (n = 31) group 2nd – DM-2 combined with ...
Daniel Pylov, Larysa Zhuravlyova
openaire +2 more sources
Background Primary pancreatic squamous cell carcinoma (SCC) is a rare type of pancreatic cancer, with an incidence of 5% of all pancreatic cancers. This condition is associated with a poor prognosis, and no optimal treatment has been established (Zhang ...
Colin Chan-Min Choi +3 more
doaj +1 more source
Severe NEUROG3 mutation underlies pancreatic endocrine and exocrine insufficiency [PDF]
Abstract Patients with NEUROG3 mutations suffer from diabetes mellitus due to pancreatic endocrinopathy and chronic malabsorptive diarrhea due to enteric endocrinopathy. We have identified a severe truncation mutation in NEUROG3 (P39PfsX38) that results in pancreatic exocrine insufficiency and significantly contributes to chronic malabsorptive
Senta Georgia +7 more
openaire +1 more source
Exocrine dysfunction correlates with endocrinal impairment of pancreas in Type 2 diabetes mellitus
Background: Diabetes mellitus (DM) is a chronic abnormal metabolic condition, which manifests elevated blood sugar level over a prolonged period. The pancreatic endocrine system generally gets affected during diabetes, but often abnormal exocrine ...
H R Prasanna Kumar +3 more
doaj +1 more source
Management of Pain, Exocrine and Endocrine Insufficiency in Chronic Pancreatitis [PDF]
Chronic pancreatitis is the progressive and inflammatory disease which will result in the irreversible destruction and fibrosis of the pancreas. These processes cause chronic pain and pancreatic dysfunctions such as exocrine and endocrine insufficiency. Medical treatment for chronic pancreatitis would be reviewed in this article.
openaire +1 more source
Cyclic AMP signalling in pancreatic islets [PDF]
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Nigel J. Pyne +7 more
core +4 more sources
Clinical Case of Newly Diagnosed Hypoglycemic Paroxysm Complicated by Severe Neurological Disorders
The paper presents a case of hypoglycemic paroxysm, manifested as epilepsy, in 53-year-old man, suffering from diabetes mellitus type 1, complicated by steatohepatosis following excretory and endocrine pancreatic insufficiency, disorders of renal ...
L.V. Shkala, M.K. Tedeyeva
doaj +1 more source

