Results 41 to 50 of about 611,039 (276)

Risk Factors Associated With Progression Toward Endocrine Insufficiency in Chronic Pancreatitis

Pancreas, 2019
Objective Little data exist describing the change over time in islet function and glycemic control in patients with chronic pancreatitis (CP). Methods In 325 CP patients who underwent 2 mixed meal tolerance tests and/or glycated hemoglobin (HbA1c) levels, we estimated the rate of ...
Barite W, Gutama, Yi, Yang, Gregory J, Beilman, Martin L, Freeman, Varvara A, Kirchner, Timothy L, Pruett, Srinath, Chinnakotla, Elissa M, Downs, Guru, Trikudanathan, Sarah J, Schwarzenberg, James S, Hodges, Melena D, Bellin   +11 more
openaire   +3 more sources

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

H+ és HCO3- transzporterek szabályozása humán pancreas ductus sejtekben = Regulation of H+ and HCO3-Transporters in Human Pancreatic Duct Cells [PDF]

, 2009
A pancreas nedvben található HCO3- ionok kiválasztásáért a pancreas ductus sejtek felelősek. Jelen pályázatban célul tűztük ki, hogy molekuláris biológiai, transzdukciós és mikrofluorescens technikák felhasználásával megértsük a HCO3- szekréció ...
Rakonczay, Zoltán
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Exocrine pancreatic insufficiency in adults: a shared position statement of the Italian association for the study of the pancreas.

, 2013
This is a medical position statement developed by the Exocrine Pancreatic Insufficiency collaborative group which is a part of the Italian Association for the Study of the Pancreas (AISP).
G. Balzano, R. Pezzilli, E. P. Insufficiency, A. Andriulli, DELLE FAVE, Gianfranco, M. Falconi, M. Cantore, C. Bassi   +7 more
core   +2 more sources

Pathological Mechanisms in Diabetes of the Exocrine Pancreas: What’s Known and What’s to Know

Frontiers in Physiology, 2020
The clinical significance of diabetes arising in the setting of pancreatic disease (also known as diabetes of the exocrine pancreas, DEP) has drawn more attention in recent years. However, significant improvements still need to be made in the recognition,
Qiong Wei, Qiong Wei, Liang Qi, Hao Lin, Hao Lin, Dechen Liu, Dechen Liu, Xiangyun Zhu, Xiangyun Zhu, Yu Dai, Richard T. Waldron, Aurelia Lugea, Mark O. Goodarzi, Stephen J. Pandol, Ling Li, Ling Li   +15 more
doaj   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source