Results 61 to 70 of about 611,039 (276)

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Redefining pancreatogenic diabetes mellitus through molecular, imaging, and AI-driven evidence

Frontiers in Endocrinology
BackgroundPancreatogenic Diabetes Mellitus (PDM), denoting diabetes secondary to fibro-inflammatory and structural pancreatic injury, represents a distinct yet under-recognised clinical entity.
Imran Rashid Rangraze, Mohamed El-Tanani, Adil Farooq Wali, Rasha Babiker, Syed Arman Rabbani, Ismail I Matalka, Shakta Mani Satyam, Ashot Avagimyan, Ashot Avagimyan, Karolina Hoffmann, Ioannis Ilias, Sorina Ispas, Maggio Viviana, Anna Paczkowska, Manfredi Rizzo, Manfredi Rizzo   +15 more
doaj   +1 more source

Diabetes and Chronic Pancreatitis: Considerations in the Holistic Management of an Often Neglected Disease

Journal of Diabetes Research, 2019
Diabetes secondary to chronic pancreatitis (CP) or type 3cDM refers to a brittle form of diabetes and is often characterised by hypoglycaemic episodes, erratic glycaemic control, and impaired quality of life.
Philip C. Johnston, Judith Thompson, Allison Mckee, Connor Hamill, Ian Wallace   +4 more
doaj   +1 more source

Pancreatic Exocrine Insufficiency in Patients Who Have Undergone Surgery Due to Pancreatic Cancer: A Chinese Cost-Utility Analysis

, 2022
Pancreatic exocrine insufficiency (PEI) is common among patients with pancreatic cancer who have undergone pancreatic surgery. Patients suffering from PEI are unable to sufficiently maintain normal digestive processes leading to malnutrition and a ...
Kim, H, Jiang, K, Fragkogianni, D, Byrnes, J, Liao, Z, Roberts, K, Kim, K   +6 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

The molecular and cellular biology of pancreatic ß cell differentiation in vitro [PDF]

, 2002
Previous studies have revealed that embryonic stem (ES) cells are capable of differentiating spontaneously towards pancreatic P cells. The use of growth factors and specific agents, such as nicotinamide, can further enhance this effect in a process known
Gammell, Patrick
core   +2 more sources

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Pancreatic Assessment in Beta Thalassemia Syndrome Patients of KPK

Pakistan Journal of Medicine and Dentistry
Background: Beta thalassemia is a hereditary hemoglobinopathy marked by ineffective erythropoiesis and progressive iron overload from early life. Iron deposition in the pancreas can impair both endocrine and exocrine function, increasing the risk of ...
Muhammad Tariq Hamayun Khan, Zubeda Irshad, Muhammad Tariq Masood Khan   +2 more
doaj   +1 more source

Exocrine pancreatic insufficiency and causes of abdominal symptoms in diabetes patients

Gastroenterology Review, 2020
The pancreas has dual functions, endocrine and exocrine, that complement each other and work closely together, contributing to the digestion, absorption, and metabolism of foods.
Roland Kadaj-Lipka, Grażyna Rydzewska
doaj   +1 more source

The Role of Pancreatitis Risk Genes in Endocrine Insufficiency Development After Acute Pancreatitis in Children

Clinical Gastroenterology and Hepatology
Acute pancreatitis (AP) is increasingly recognized as a risk factor for diabetes mellitus (DM). We aimed to study the association of pancreatitis genes with pancreatic endocrine insufficiency (pre-DM and DM) development post-AP in children.This was an observational cohort study that enrolled subjects ≤21 years with their first episode of AP and ...
Abu-El-Haija, Maisam, Zhang, Wenying, Karns, Rebekah, Ginzburg, Gila, Vitale, David S., Farrell, Peter, Nasr, Alexander, Ibrahim, Sherif, Bellin, Melena D., Thompson, Tyler, Garlapally, Vineet, Woo, Jessica G., Husain, Sohail Z, Denson, Lee A.   +13 more
openaire   +2 more sources