Results 91 to 100 of about 2,258,907 (387)

Targeting trafficking as a therapeutic avenue for misfolded GPCRs leading to endocrine diseases

Frontiers in Endocrinology, 2022
G protein-coupled receptors (GPCRs) are plasma membrane proteins associated with an array of functions. Mutations in these receptors lead to a number of genetic diseases, including diseases involving the endocrine system.
Alfredo Ulloa-Aguirre, Teresa Zariñán, Rubén Gutiérrez-Sagal, Ya-Xiong Tao   +3 more
doaj   +1 more source

Role of psychosocial stress in complex diseases [PDF]

, 2012
peer reviewedComplex diseases are chronic diseases where the interrelations between genetic predisposition and environmental factors play an essential role in the arisen and the maintenance of the pathology.
Scantamburlo, Gabrielle, SCHEEN, André
core  

Metabolism disrupting chemicals and metabolic disorders [PDF]

, 2017
The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging.
Blumberg, Bruce, Cave, Mathew, Heindel, Jerrold J., Machtinger, Ronit, Mantovani, Alberto, Mendez, Michelle A., Nadal, Angel, Palanza, Paola, Panzica, Giancarlo, Sargis, Robert, Vandenberg, Laura N., vom Saal, Frederick   +11 more
core   +2 more sources

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Reduced model for female endocrine dynamics: Validation and functional variations [PDF]

arXiv, 2020
A normally functioning menstrual cycle requires significant crosstalk between hormones originating in ovarian and brain tissues. Reproductive hormone dysregulation may cause abnormal function and sometimes infertility. The inherent complexity in this endocrine system is a challenge to identifying mechanisms of cycle disruption, particularly given the ...
arxiv  

Gender in endocrine diseases: role of sex gonadal hormones [PDF]

, 2018
Gender- and sex- related differences represent a new frontier towards patient-tailored medicine, taking into account that theoretically every medical specialty can be influenced by both of them.
Appetecchia, M., Lauretta, R., Romanelli, F., Sansone, A., Sansone, M.   +4 more
core   +2 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Review on Application of Drone in Spraying Pesticides and Fertilizers [PDF]

International Journal of Engineering Research & Technology (IJERT), Vol. 10 Issue 11, November-2021
In today's agriculture, there are far too many innovations involved. One of the emerging technologies is pesticide spraying using drones. Manual pesticide spraying has a number of negative consequences for the people who are involved in the spraying operation.
arxiv   +1 more source

Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept [PDF]

, 2017
In the last few years, more attention has been given to the "non-calcemic" effect of vitamin D. Several observational studies and meta-analyses demonstrated an association between circulating levels of vitamin D and outcome of many common diseases ...
Altieri, Barbara, Altieri, Vincenzo M, Balercia, Giancarlo, Barrea, Luigi, Bizzaro, Giorgia, Bizzaro, Nicola, Colao, Annamaria, Della Casa, Silvia, Mascitelli, Luca, Mathieu, Chantal, Muscogiuri, Giovanna, Pontecorvi, Alfredo, Ronchi, Cristina L, Savastano, Silvia, Tirabassi, Giacomo, Vallone, Carla V   +15 more
core   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source