Results 111 to 120 of about 119,873 (307)
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Rolf Christian Gaillard (1944-2011): A builder of modern European endocrinology and neuroendocrinology. [PDF]
J NeuroendocrinolRolf Christian Gaillard was a Swiss physician, scientist, and academic leader whose career contributed significantly to the development of modern European endocrinology and neuroendocrinology. Among his most remarkable qualities was an exceptional talent
Chanson P, Spinedi E, Pralong F.
europepmc +2 more sources
Monthly or menstrual? A scoping review of catamenial epilepsy and non‐menstrual seizure rhythms
Epilepsia, EarlyView.Abstract Objective Despite the reported high prevalence of catamenial epilepsy (CE), the condition remains poorly defined, with lack of consensus on what entails a menstrual‐related seizure exacerbation. Emerging evidence of multiday cycles of seizure activity, including about‐monthly cycles, present in both men and women, further confound the ...
Victoria Wong +4 more
wiley +1 more source
Frontiers in EndocrinologyBackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and pancreatic β-cell dysfunction. T2DM is associated with increased risk of infections and of several malignancies, although the underlying ...
Emilia Adamska-Fita +8 more
doaj +1 more source
Metabolic signaling functions of ER–mitochondria contact sites : Role in metabolic diseases
, 2017 Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER– mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal ...
Rieusset, Jennifer +5 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective A significant proportion of individuals with suspected genetic developmental and epileptic encephalopathies (DEEs) remain unsolved following whole genome sequencing (WGS). Here we describe biallelic RNU2‐2 variants causing a recently reported, severe, recessive DEE.
Olivia J. Henry +23 more
wiley +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Clinical DiabetologyOBJECTIVE: Insulin resistance (IR) is a disruption in glucose homeostasis characterized by decreased tissue sensitivity to insulin. One of the main causes of IR is considered to be obesity, a significant problem in contemporary medicine.
Jakub Gołacki +6 more
doaj +1 more source
Secondary hypertension and resistant hypertension may result from potentially treatable acquired or hereditary diseases. Inherited Metabolic Disorders are not routinely included in the differential diagnosis of these contexts associated with hypertension,
Paulo Sgobbi +11 more
core +1 more source
European Eating Disorders Review, EarlyView.ABSTRACT Background Food intake is highly aversive for patients with anorexia nervosa (AN), and fear of weight gain is closely linked to altered eating behaviours, including reduced portion sizes. This study investigated how portion size estimation develops longitudinally in patients with AN during inpatient treatment.
Katrin E. Giel +8 more
wiley +1 more source