Results 41 to 50 of about 593 (134)

Effects of an anti-IGF-1 receptor monoclonal antibody on laminitis induced by prolonged hyperinsulinaemia in Standardbred horses.

PLoS ONE, 2020
Currently, there are no registered veterinary drugs for the treatment of endocrinopathic equine laminitis, and although this form of the disease is known to be caused by prolonged hyperinsulinaemia, the mechanism of insulin toxicity is unclear.
Samira Rahnama, Niveditha Vathsangam, Robert Spence, Carlos E Medina-Torres, Christopher C Pollitt, Melody A de Laat, Simon R Bailey, Martin N Sillence   +7 more
doaj   +2 more sources

Metabolic profile distinguishes laminitis-susceptible and -resistant ponies before and after feeding a high sugar diet

BMC Veterinary Research, 2021
Background Insulin dysregulation (ID) is a key risk factor for equine endocrinopathic laminitis, but in many cases ID can only be assessed accurately using dynamic tests.
Julien Delarocque, Dania B. Reiche, Alexandra D. Meier, Tobias Warnken, Karsten Feige, Martin N. Sillence   +5 more
doaj   +1 more source

Palatability, glycemic, and insulinemic responses to various carbohydrate formulations: Alternatives for the diagnosis of insulin dysregulation in horses?

Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 282-291, January/February 2023., 2023
Abstract Background Oral glycemic challenge (GC) tests are recommended for diagnosis of insulin dysregulation (ID). Various protocols are used, but all have limitations in terms of palatability, ease of use, variable composition, geographic availability, or some combination of these.
Tobias Warnken, Claudia Schaub, Julien Delarocque, Florian Frers, Karsten Feige, Johanna Sonntag, Dania Birte Reiche   +6 more
wiley   +1 more source

Comparison and validation of ELISA assays for plasma insulin-like growth factor-1 in the horse [PDF]

Open Veterinary Journal, 2017
Insulin-like growth factor-1 (IGF-1) plays several important physiological roles, and IGF-related pathways have been implicated in developmental osteochondral disease and endocrinopathic laminitis.
Courtnay L. Baskerville, Nicholas J. Bamford, Patricia A. Harris, Simon R. Bailey   +3 more
doaj   +1 more source

Association of sustained supraphysiologic hyperinsulinemia and inflammatory signaling within the digital lamellae in light‐breed horses

Journal of Veterinary Internal Medicine, 2019
Background Hyperinsulinemia is associated with equine laminitis, and digital lamellar inflammation in equine metabolic syndrome‐associated laminitis (EMSAL) is modest when compared with sepsis‐associated laminitis.
Mauria R. Watts, Olivia C. Hegedus, Susan C. Eades, James K. Belknap, Teresa A. Burns   +4 more
doaj   +1 more source

Unusual Spinal Epidural Lipomatosis and Lumbosacral Instability

Case Reports in Orthopedics, 2016
Introduction. Epidural lipomatosis is most frequently observed in patients on chronic steroid treatment. Only a few idiopathic epidural lipomatosis cases have been described. Material and Methods. 64-year-old male patient presented with low back pain and
David Ruiz Picazo, José Ramírez Villaescusa   +1 more
doaj   +1 more source

Screening of polymorphisms of transcription factor 7-like 2 gene in polycystic ovary syndrome using polymerase chain reaction-restriction fragment length polymorphism analysis

Journal of Human Reproductive Sciences, 2018
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder occurring in premenopausal women, with a prevalence rate of 5%–7%. It has been observed in multiple number of studies the coexistence between diabetes mellitus 2 and obesity with
Yogamaya D Prabhu, Nishu Sekar, V G Abilash   +2 more
doaj   +1 more source

Response of intact vessels from healthy horses and horses with endocrinopathic laminitis (EL) to vasoconstrictors.

, 2016
Response of intact vessels from healthy horses and horses with endocrinopathic laminitis (EL) to vasoconstrictors.
Patrick W. F. Hadoke (206485), Ruth A. Morgan (3185121), Brian R. Walker (229836), John A. Keen (3185124)   +3 more
core   +1 more source

Clinical and biochemical characteristics of the study groups; healthy and those with endocrinopathic laminitis (EL).

, 2016
Clinical and biochemical characteristics of the study groups; healthy and those with endocrinopathic laminitis (EL).
Patrick W. F. Hadoke (206485), Ruth A. Morgan (3185121), Brian R. Walker (229836), John A. Keen (3185124)   +3 more
core   +1 more source

Updates on intra‐articular corticosteroid administration in horses

Equine Veterinary Education, EarlyView.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner, L. Bass, C. Kawcak, L. V. Schnabel, K. L. Hallowell, L. M. Pezzanite   +5 more
wiley   +1 more source