Results 1 to 10 of about 64,404 (299)

An endocytic-secretory cycle participates in Toxoplasma gondii in motility. [PDF]

PLoS Biology, 2019
Apicomplexan parasites invade host cells in an active process involving their ability to move by gliding motility. While the acto-myosin system of the parasite plays a crucial role in the formation and release of attachment sites during this process ...
Simon Gras, Elena Jimenez-Ruiz, Christen M Klinger, Katja Schneider, Andreas Klingl, Leandro Lemgruber, Markus Meissner   +6 more
doaj   +7 more sources

Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.

PLoS Pathogens, 2015
Influenza virus particles are assembled at the plasma membrane in concert with incorporation of the virus genome, but the details of its spatio-temporal regulation are not understood.
Atsushi Kawaguchi, Mikako Hirohama, Yoshimi Harada, Suguru Osari, Kyosuke Nagata   +4 more
doaj   +6 more sources

TCA cycle impairment leads to PIN2 internalization and degradation via reduced MAB4 level and ARA6 components in Arabidopsis roots [PDF]

Frontiers in Plant Science
The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial role in linking the glycolysis pathway and the tricarboxylic acid (TCA) cycle. Previously, we reported that a mutation of MAB1, encoding an E1β subunit of PDC, affects the abundance ...
Xiaomin Song, Xiaomin Song, Iwai Ohbayashi, Iwai Ohbayashi, Iwai Ohbayashi, Song Sun, Qiuli Wang, Qiuli Wang, Yi Yang, Yi Yang, Mengyuan Lu, Mengyuan Lu, Yuanyuan Liu, Shinichiro Sawa, Shinichiro Sawa, Shinichiro Sawa, Shinichiro Sawa, Masahiko Furutani, Masahiko Furutani, Masahiko Furutani, Masahiko Furutani, Masahiko Furutani   +21 more
doaj   +2 more sources

Cell cycle-dependent endocytosis of DNA-wrapped single-walled carbon nanotubes by neural progenitor cells

Biophysical Reports, 2022
While exposure of C17.2 neural progenitor cells (NPCs) to nanomolar concentrations of carbon nanotubes (NTs) yields evidence of cellular substructure reorganization and alteration of cell division and differentiation, the mechanisms of NT entry are not ...
Swetha Chandrasekar, Sophia Kuipa, Ana I. Vargas, Tetyana Ignatova, Slava V. Rotkin, Sabrina S. Jedlicka   +5 more
doaj   +1 more source

Identification and characterization of an unusual class I myosin involved in vesicle traffic in Trypanosoma brucei. [PDF]

PLoS ONE, 2010
Myosins are a multimember family of motor proteins with diverse functions in eukaryotic cells. African trypanosomes possess only two candidate myosins and thus represent a useful system for functional analysis of these motors.
Diana Spitznagel, John F O'Rourke, Neal Leddy, Orla Hanrahan, Derek P Nolan   +4 more
doaj   +1 more source

Cytokinin Inhibits Fungal Development and Virulence by Targeting the Cytoskeleton and Cellular Trafficking

mBio, 2021
Cytokinin (CK) is an important plant developmental regulator, having activities in many aspects of plant life and response to the environment. CKs are involved in diverse processes in the plant, including stem cell maintenance, vascular differentiation ...
Rupali Gupta, Gautam Anand, Lorena Pizarro, Dana Laor Bar-Yosef, Neta Kovetz, Noa Sela, Tal Yehuda, Ehud Gazit, Maya Bar   +8 more
doaj   +1 more source

Impact of Endocytosis Mechanisms for the Receptors Targeted by the Currently Approved Antibody-Drug Conjugates (ADCs)—A Necessity for Future ADC Research and Development

Pharmaceuticals, 2021
Biologically-based therapies increasingly rely on the endocytic cycle of internalization and exocytosis of target receptors for cancer therapies. However, receptor trafficking pathways (endosomal sorting (recycling, lysosome localization) and lateral ...
Manar Hammood, Andrew W. Craig, Jeffrey V. Leyton   +2 more
doaj   +1 more source

Elucidation of the Cellular Interactome of African Swine Fever Virus Fusion Proteins and Identification of Potential Therapeutic Targets

Viruses, 2023
African swine fever virus (ASFV) encodes more than 150 proteins, most of them of unknown function. We used a high-throughput proteomic analysis to elucidate the interactome of four ASFV proteins, which potentially mediate a critical step of the infection
Isabel García-Dorival, Miguel Ángel Cuesta-Geijo, Inmaculada Galindo, Ana del Puerto, Lucía Barrado-Gil, Jesús Urquiza, Covadonga Alonso   +6 more
doaj   +1 more source

Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors

Neurobiology of Disease, 2020
ARFGEF1 encodes a guanine exchange factor involved in intracellular vesicle trafficking, and is a candidate gene for childhood genetic epilepsies. To model ARFGEF1 haploinsufficiency observed in a recent Lennox Gastaut Syndrome patient, we studied a ...
JiaJie Teoh, Narayan Subramanian, Maria Elena Pero, Francesca Bartolini, Ariadna Amador, Ayla Kanber, Damian Williams, Sabrina Petri, Mu Yang, Andrew S. Allen, Jules Beal, Sheryl R. Haut, Wayne N. Frankel   +12 more
doaj   +1 more source

Multifaceted membrane binding head of the SARS-CoV-2 spike protein

Current Research in Structural Biology, 2022
The SARS-CoV-2 spike protein presents a surface with enormous membrane binding potential to host tissues and organelles of infected cells. Its exposed trimeric head binds not only the angiotensin-converting enzyme 2 (ACE2), but also host phospholipids ...
Anh Tran, Troy A. Kervin, Michael Overduin   +2 more
doaj   +1 more source