Results 141 to 150 of about 64,404 (299)

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Host factor Rab4b promotes the replication of influenza A virus

Biosafety and Health
Rab proteins are involved in all facets of the vesicular transport process and play significant roles in different steps of the viral life cycle. Rab4b is a pivotal player in the endocytic recycling of proteins, whereas its roles in viral replication are
Yilu Ye, Tingting Sun, Saisai Guo, Jianyuan Zhao, Xiaoyu Li, Jing Wang, Shan Cen   +6 more
doaj   +1 more source

Conductive Microneedles Loaded With Polyphenol‐Engineered Exosomes Reshape Diabetic Neurovascular Niches for Chronic Wound Healing

Advanced Science, EarlyView.
This study establishes a bio‐electroceutical interface by synergizing engineered exosome‐derived biological signals with electroconductive microneedle‐delivered electrical cues, achieving dual‐pathway reprogramming of the diabetic neurovascular niches and accelerating wound healing. Abstract Diabetic wound healing remains a major clinical challenge due
Di Liu, Jingxian Gao, Xueling Wu, Xinxin Hao, Wenxiu Hu, Lu Han   +5 more
wiley   +1 more source

Decoy Extracellular Vesicles Overcome Triple‐Negative Breast Cancer Heterogeneity via Membrane‐Cytoplasm‐Mitochondria Cascade Targeting

Advanced Science, EarlyView.
siT/MOF@EVs overcome TNBC heterogeneity through a tumor cell membrane–cytoplasm–mitochondria cascade effect, triggering a self‐reinforcing anti‐tumor immune cycle and durable immune memory. The system enables sequential targeting of membrane checkpoints ligands (decoy effect), cytoplasmic siRNA delivery (CSC suppression), and mitochondrial MOF ...
Chuanrong Chen, Ming Shen, Xiaofeng Wan, Lili Sheng, Na Hao, Man Li, Menglin Xu, Yang He, Jiali Zhang   +8 more
wiley   +1 more source

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source

CHARACTERIZATION OF THE UBIQUITIN LIGASE, UBE4B, IN ENDOCYTIC TRAFFICKING [PDF]

, 2017
Endocytosis is a process by which cells internalize membrane proteins to remove them from the plasma membrane, allowing cells to regulate the cell surface expression of transmembrane proteins.
Sirisaengtaksin, Natalie, Sirisaengtaksin, Natalie   +1 more
core   +1 more source

Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression

Advanced Science, EarlyView.
This study demonstrated that ATG4B translocates from the cytoplasm to the nucleus during energy deficiency. Nuclear ATG4B inhibits DNA repair by interacting with PRMT1. The nuclear ATG4B‐mediated DNA repair defect is significantly exacerbated within acute myeloid leukemia (AML) cells, promoting leukemia progression in an AML mouse model.
Zhenkun Wang, Xianli Zhang, Yuanyuan Zhou, Shuyi Lin, Yuting Fu, Haiping Liu, Qiongdan Gao, YanHong Xiao, Zhao Yin, Shuang Liu, Kexiu Huang, Suqi Deng, Juan Du, Hui Zeng, Jia Wang, Jinping Zheng, Qinghua Zhou, Tianfeng Chen, Xiaoling Gao, Zhenyu Ju, Bo Liu   +20 more
wiley   +1 more source

Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus

Advanced Science, EarlyView.
In wild‐type of M. oryzae (Guy11), MoPrb1 and MoPep4 are delivered into the vacuole by the retromer complex to mediate protein degradation and selective autophagy. Their proper localization and catalytic functions are essential for the fungal vegetative growth, conidiation and pathogenicity. However, retromer mutations disrupt this transport, impairing
Dingyang Zhang, Jiexiong Hu, Yonghe Hong, Yuping Fan, Minghui Peng, Yakubu Saddeeq Abubakar, Shujing Liang, Nan Jiang, Lili Lin, Xiaohong Pan, Huakun Zheng, Naweed I. Naqvi, Zonghua Wang, Wenhui Zheng   +13 more
wiley   +1 more source

Enhanced Single‐Particle Upconversion Imaging via Energy Migration Boosting

Advanced Science, EarlyView.
A core‐shell‐shell Yb3⁺/Er3⁺ UCNP architecture is engineered to balance energy migration and back energy transfer, yielding more than a tenfold enhancement in single‐particle brightness. Leveraging these optimized probes, it achieves long‐term, high‐resolution single‐particle tracking in live neurons, uncovering coordinated transport mechanisms of ...
Yanxin Zhang, Rongrong Wen, Tianli Zhai, Wenrui Zhang, Fan Ding, Huan Ling, Yunxiang Zhang, Qian Liu   +7 more
wiley   +1 more source

A Mesoporous Calcium Peroxide Nanocuboid with High Tumor Accumulation Across Biological Barriers for High Efficacy Tumor Therapy

Advanced Science, EarlyView.
The ferroheme (FH) and exceedingly small magnetic iron oxide nanoparticles (IO) loaded mesoporous calcium peroxide nanocuboid (MCPNC) with conjugation of hyaluronic acid (HA) possesses exceptional capability of tumor accumulation, and enhances therapeutic efficacy of tumors based on the mechanism of promoting a positive feedback loop of Fenton reaction
Qingdeng Fan, Min Wang, Jie Lin, Ya Huang, Jing Yang, Jiaoyang Zhu, Bin Ren, Li Sun, Zongheng Li, Aochi Liu, Wei Xiong, Zhenni Wei, Lin Huang, Chenggong Yan, Ge Wen, Zhao Chen, Xiaoyuan Chen, Zheyu Shen   +17 more
wiley   +1 more source