Constitutive Endocytic Cycle of the CB1 Cannabinoid Receptor [PDF]
Journal of Biological Chemistry, 2004 The CB1 cannabinoid receptor (CB1R) displays a significant level of ligand-independent (i.e. constitutive) activity, either when heterologously expressed in nonneuronal cells or in neurons where CB1Rs are endogenous. The present study investigates the consequences of constitutive activity on the intracellular trafficking of CB1R.
Christophe Leterrier +4 more
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pH‐Independent Endocytic Cycling of the Chemokine Receptor CCR5 [PDF]
Traffic, 2004 Following agonist activation, the chemokine receptor CCR5 is internalised through clathrin‐coated pits and delivered to recycling endosomes. Subsequently, ligand‐ free and resensitised receptors are recycled to the cell surface. Currently little is known of the mechanisms regulating resensitisation and recycling of this G‐protein coupled receptor. Here
Nathalie Signoret +3 more
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Apicomplexan motility depends on the operation of an endocytic-secretory cycle [PDF]
, 2018 ABSTRACTApicomplexan parasites invade host cells in an active process, involving their ability to move by gliding motility and invasion. While the acto-myosin-system of the parasite plays a crucial role in the formation and release of attachment sites during this process, there are still open questions, such as how the force powering motility is ...
Simon Gras +4 more
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The Tetraspanin CD63/lamp3 Cycles between Endocytic and Secretory Compartments in Human Endothelial Cells [PDF]
Molecular Biology of the Cell, 2000 In the present study, we show that in human endothelial cells the tetraspanin CD63/lamp3 distributes predominantly to the internal membranes of multivesicular–multilamellar late endosomes, which contain the unique lipid lysobisphosphatidic acid. Some CD63/lamp3 is also present in Weibel–Palade bodies, the characteristic secretory organelle of these ...
Toshihide Kobayashi +7 more
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Slow Diffusion of Proteins in the Yeast Plasma Membrane Allows Polarity to Be Maintained by Endocytic Cycling [PDF]
Current Biology, 2003 Many cells show a polarized distribution of some plasma membrane proteins, which may be maintained either by a diffusion barrier or kinetically: as first demonstrated in fibroblasts, locally exocytosed proteins will remain polarized if they are endocytosed and recycled before they can diffuse to equilibrium.
Javier Valdez Taubas, Hugh R.B. Pelham
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Lowe syndrome–linked endocytic adaptors direct membrane cycling kinetics with OCRL inDictyostelium discoideum [PDF]
Molecular Biology of the Cell, 2019 Mutations of the inositol 5-phosphatase OCRL cause Lowe syndrome (LS), characterized by congenital cataract, low IQ, and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL’s interactions with endocytic adaptors containing F&H peptide motifs. Converging unbiased methods examining human peptides and the unicellular
Alexandre Lüscher +13 more
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Apotransferrin and Holotransferrin Undergo Different Endocytic Cycles in Intestinal Epithelia (Caco-2) Cells [PDF]
Journal of Biological Chemistry, 1997 Previous studies have demonstrated that diferric transferrin and apotransferrin compete for the binding to basolateral transferrin receptors and that transferrin-mediated iron uptake by Caco-2 cells is inhibited by apotransferrin to a larger extent than that predicted solely by receptor competition.
Marco T. Núñez +4 more
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Postsynaptic Positioning of Endocytic Zones and AMPA Receptor Cycling by Physical Coupling of Dynamin-3 to Homer [PDF]
Neuron, 2007 Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs), stably positioned sites of clathrin assembly adjacent to the postsynaptic density (PSD). The tight localization of postsynaptic endocytosis is thought to control spine composition and regulate synaptic transmission and plasticity.
Jiuyi Lü +6 more
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Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration [PDF]
Proceedings of the National Academy of Sciences, 2010 Border cell migration is a stereotyped migration occurring during the development of the Drosophila egg chamber. During this process, a cluster composed of six to eight follicle cells migrates between nurse cells toward the oocyte.
Gloria Assaker +4 more
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Drosophila CTP synthase regulates collective cell migration by controlling the polarized endocytic cycle [PDF]
Development, 2022 ABSTRACT Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) is involved in many biological functions. However, the mechanisms of PIP2 in collective cell migration remain elusive. This study highlights the regulatory role of cytidine triphosphate synthase (CTPsyn) in collective border cell migration through regulating the asymmetrical ...
Pei-Yu Wang +10 more
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