Results 11 to 20 of about 3,012,914 (272)
Lowe syndrome–linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum [PDF]
Molecular Biology of the Cell, 2019 Mutations of the inositol 5-phosphatase OCRL cause Lowe syndrome (LS), characterized by congenital cataract, low IQ, and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL’s interactions with endocytic adaptors containing F&H peptide motifs. Converging unbiased methods examining human peptides and the unicellular
Alexandre Lüscher +13 more
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Apotransferrin and Holotransferrin Undergo Different Endocytic Cycles in Intestinal Epithelia (Caco-2) Cells [PDF]
Journal of Biological Chemistry, 1997 Previous studies have demonstrated that diferric transferrin and apotransferrin compete for the binding to basolateral transferrin receptors and that transferrin-mediated iron uptake by Caco-2 cells is inhibited by apotransferrin to a larger extent than that predicted solely by receptor competition.
Marco T. Núñez +4 more
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Drosophila CTP synthase regulates collective cell migration by controlling the polarized endocytic cycle [PDF]
Development, 2022 ABSTRACT Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) is involved in many biological functions. However, the mechanisms of PIP2 in collective cell migration remain elusive. This study highlights the regulatory role of cytidine triphosphate synthase (CTPsyn) in collective border cell migration through regulating the asymmetrical ...
Pei-Yu Wang +10 more
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Endocytic Cycling of Glucose Transporters and Insulin Resistance Due to Immunosuppressive Agents
The Journal of Clinical Endocrinology & Metabolism, 2014 For many investigators studying type 2 diabetes, the term “insulin resistance” has become synonymous with impaired signaling immediately downstream of the insulin receptor (IR). There is good reason for this. Early studies of impaired insulin action in diabetes identified “receptor” and “postreceptor” defects; most impairment was in the postreceptor ...
Jonathan S. Bogan
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The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway [PDF]
Molecular Biology of the Cell, 2003 Rho GTPases are key regulators of actin dynamics. We report that the Rho GTPase TCL, which is closely related to Cdc42 and TC10, localizes to the plasma membrane and the early/sorting endosomes in HeLa cells, suggesting a role in the early endocytic pathway.
Marion de Toledo +6 more
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Postsynaptic Positioning of Endocytic Zones and AMPA Receptor Cycling by Physical Coupling of Dynamin-3 to Homer [PDF]
Neuron, 2007 Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs), stably positioned sites of clathrin assembly adjacent to the postsynaptic density (PSD). The tight localization of postsynaptic endocytosis is thought to control spine composition and regulate synaptic transmission and plasticity.
Jiuyi Lü +6 more
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PLoS ONE, 2020 Early endosomes, regarded as the main sorting station on endocytic pathway, are characterized by high frequency of homotypic fusions mediated by tethering protein EEA1.
Rimma Kamentseva +7 more
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The menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal [PDF]
Human Molecular Genetics, 1999 Menkes disease is an X-linked recessive copper deficiency disorder caused by mutations in the ATP7A ( MNK ) gene which encodes a copper transporting P-type ATPase (MNK). MNK is normally localized pre- dominantly in the trans -Golgi network (TGN); however, when cells are exposed to excessive copper it is rapidly relocalized to the plasma membrane where ...
Michael J. Petris
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Slow Diffusion of Proteins in the Yeast Plasma Membrane Allows Polarity to Be Maintained by Endocytic Cycling [PDF]
Current Biology, 2003 Many cells show a polarized distribution of some plasma membrane proteins, which may be maintained either by a diffusion barrier or kinetically: as first demonstrated in fibroblasts, locally exocytosed proteins will remain polarized if they are endocytosed and recycled before they can diffuse to equilibrium.
Javier Valdez Taubas, Hugh R.B. Pelham
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Frontiers in Cellular and Infection Microbiology, 2020 Trypanosoma cruzi is the parasite causative of Chagas disease, a highly disseminated illness endemic in Latin-American countries. T. cruzi has a complex life cycle that involves mammalian hosts and insect vectors both of which exhibits different ...
Betiana Nebaí Salassa +6 more
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