Results 191 to 200 of about 64,404 (299)

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Lipid asymmetry and membrane trafficking: Transbilayer distribution of structural phospholipids as regulators of exocytosis and endocytosis. [PDF]

J Biol Chem
Caputo M, Gubar O, Tóth P, Vitale N, Gasman S, Ory S.   +5 more
europepmc   +1 more source

YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice

Cell Proliferation, EarlyView.
Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen, Xiaochen Yu, Ziqi Wang, Wenbo Liu, Jianze Xu, Qian Fang, Fei Gao, Yongzhi Cao, Hongbin Liu   +8 more
wiley   +1 more source

Bioinformatics and system biology approach to discover the common pathogenetic processes between COVID-19 and chronic hepatitis B. [PDF]

PLoS One
Ma X, Huang T, Song Y, Pan H, Du A, Zhou X, Zeng Y, Yuan K.   +7 more
europepmc   +1 more source

Cadherin‐6 controls neuronal migration during mouse neocortical development via an integrin‐mediated pathway

The FEBS Journal, EarlyView.
Neuronal migration plays essential roles in the establishment of mammalian brains, and its impairment causes severe developmental abnormalities and behavioral and cognitive deficits. Here, we report that cadherin‐6 (CDH6), an unusual cadherin molecule containing an RGD integrin‐binding motif in the first extracellular domain, controls the motility of ...
Yuki Hirota, Rikaho Saito, Takao Honda, Hitomi Sano, Mayuko Hotta, Yukiko U. Inoue, Takayoshi Inoue, Kazunori Nakajima   +7 more
wiley   +1 more source

The Different Cellular Entry Routes for Drug Delivery Using Cell Penetrating Peptides. [PDF]

Biol Cell
Okafor M, Schmitt D, Ory S, Gasman S, Hureau C, Faller P, Vitale N.   +6 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

The molecular sub-type and the development and validation of a prognosis prediction model based on endocytosis-related genes for hepatocellular carcinoma. [PDF]

J Gastrointest Oncol
Zhang L, Zhou D, Gao X, Li J, Xie X.
europepmc   +1 more source

Multi‐omics analysis reveals discordant proteome and transcriptome responses in larval guts of Frankliniella occidentalis infected with an orthotospovirus

Insect Molecular Biology, EarlyView.
Tomato spotted wilt virus modulated the abundance of gut proteins in larval thrips, most notably manifested as a predominant down‐regulation in first instar larvae. Gut‐expressed protein and cognate transcript abundance were moderately correlated across the tissue system; however, the virus effect varied widely at transcriptional and translational ...
Jinlong Han, Dorith Rotenberg
wiley   +1 more source

Mdm2-Mediated Ubiquitination Plays a Pivotal Role in Differentiating the Endocytic Roles of GRK2 and Arrestin3. [PDF]

Int J Mol Sci
Wang S, Kundu D, Zhang X, Tian X, Peng L, Kim KM.   +5 more
europepmc   +1 more source