Results 221 to 230 of about 64,404 (299)

Insight into the Life Cycle of Enterovirus-A71. [PDF]

Viruses
Liu Q, Long JE.
europepmc   +1 more source

Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins

The Journal of Physiology, EarlyView.
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape, Natali L. Chanaday, Merve Kasap, Lisa M. Monteggia, Ege T. Kavalali   +4 more
wiley   +1 more source

Macropinosomes are a site of HIV-1 entry into primary CD4⁺ T cells. [PDF]

Proc Natl Acad Sci U S A
Murakami T, Cardoso RS, Manivannan P, Chang YT, Rentchler E, Chou KN, Tang Y, Swanson JA, King PD, Ono A.   +9 more
europepmc   +1 more source

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

Cross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis. [PDF]

Cell Rep
Ren Y, Yang J, Fujita B, Zhang Y, Berro J.   +4 more
europepmc   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Herpes simplex virus 1 glycoprotein C promotes virus penetration from endosomes during entry, independent of interaction with heparan sulfate. [PDF]

Front Microbiol
Schneider SM, Tebaldi G, Gianopulos KA, Weed DJ, Pritchard SM, Leach C, Nicola AV.   +6 more
europepmc   +1 more source

Tenascin‐R aggravates Aβ production in the perforant pathway by regulating Nav1.6 activity in APP/PS1 mice

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) neuropathology exhibits early accumulation of amyloid beta (Aβ) plaques within the perforant pathway. This study explores how tenascin‐R, a myelin‐associated protein at nodes of Ranvier (NORs), modulates Aβ generation through Nav1.6 within this cortico‐hippocampal circuit.
Bin Wang, Zhi‐Xue Wang, Lang‐Man Lv, Xi Wang, Jin‐Cheng Lu, Yi‐Fan Zhao, Rong Jiang, Qi‐fa Li, Yue Kong, Xue‐Wei Yang, Jie Luo, Zhi‐Cheng Xiao, Ai‐ping Li, Guang Yang, Quan‐Hong Ma, Li Shao   +15 more
wiley   +1 more source

LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis. [PDF]

Orthop Surg
Wu Y, Sun K, Li M, Yang Y, Liu Y, Wu L, Ding Y, Zeng Y, Shen B.   +8 more
europepmc   +1 more source