Results 231 to 240 of about 64,404 (299)

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

open access: yesAnnals of Neurology, Volume 98, Issue 3, Page 448-470, September 2025.
[Color figure can be viewed at www.annalsofneurology.org] Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical ...
Brent L. Fogel   +10 more
wiley   +1 more source

Extracellular Vesicles in Arthropods: Biogenesis, Functions, Isolation Methods and Applications

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound nanoparticles secreted by cells that are involved in multiple forms of intercellular communication and show promising potential for biotechnological applications. Arthropod‐derived EV research remains relatively fragmented in contrast to the extensively studied mammalian EV field. In this review,
Simon Remans   +3 more
wiley   +1 more source

MicroRNA (miRNA) in Plasma Small Extracellular Vesicles (sEV) as Potential Early Indicators of Dairy Cow Subfertility

open access: yesJournal of Extracellular Biology, Volume 4, Issue 9, September 2025.
ABSTRACT Pregnancy and live birth rates are commonly used metrics to define fertility in humans and animals. The impact of aberrant microRNA (miRNA) expression on fertility‐related genes represents a significant knowledge gap in understanding post‐transcriptional regulatory mechanisms associated with reproductive dysfunction.
Pevindu Abeysinghe   +5 more
wiley   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

open access: yesMedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen   +4 more
wiley   +1 more source

Recent Progress in Gene Delivery Systems Based on Gemini‐Surfactant

open access: yesMedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Gene delivery is a key area in biomedicine, where nucleic acids are delivered into cells to treat diseases by modulating genes. The low micelle concentration, effective nucleic acid complexation, and low immunogenicity make Gemini surfactants promising gene delivery vectors.
Peng Qian   +5 more
wiley   +1 more source

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