The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway [PDF]
Molecular Biology of the Cell, 2003 Rho GTPases are key regulators of actin dynamics. We report that the Rho GTPase TCL, which is closely related to Cdc42 and TC10, localizes to the plasma membrane and the early/sorting endosomes in HeLa cells, suggesting a role in the early endocytic pathway.
Marion de Toledo +6 more
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Journal of Biological Chemistry, 1993 The prion protein (PrPC) is a glycolipid-anchored, cell surface protein of unknown function, a posttranslationally modified isoform of which has been implicated in the pathogenesis of spongiform encephalopathies in man and animals. We report here the novel observation that chPrP, the chicken homologue of mammalian PrPC, constitutively cycles between ...
Show‐Ling Shyng +2 more
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Unconventional Functions for Clathrin, ESCRTs, and Other Endocytic Regulators in the Cytoskeleton, Cell Cycle, Nucleus, and Beyond: Links to Human Disease [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 The roles of clathrin, its regulators, and the ESCRT (endosomal sorting complex required for transport) proteins are well defined in endocytosis. These proteins can also participate in intracellular pathways that are independent of endocytosis and even independent of the membrane trafficking function of these proteins.
Frances M. Brodsky +3 more
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Inositol transport in Saccharomyces cerevisiae is regulated by transcriptional and degradative endocytic mechanisms during the growth cycle that are distinct from inositol-induced regulation. [PDF]
Molecular Biology of the Cell, 1996 Regulation of inositol uptake activity in Saccharomyces cerevisiae during the growth cycle was examined. Activity increased as the cell population transited from lag phase to exponential growth, and continued to increase until late exponential phase. The increase in activity was due to increased transcription of the ITR1 gene and synthesis of the Itr1
Katherine Robinson +3 more
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Endocytic Cycling of Glucose Transporters and Insulin Resistance Due to Immunosuppressive Agents
The Journal of Clinical Endocrinology & Metabolism, 2014 For many investigators studying type 2 diabetes, the term “insulin resistance” has become synonymous with impaired signaling immediately downstream of the insulin receptor (IR). There is good reason for this. Early studies of impaired insulin action in diabetes identified “receptor” and “postreceptor” defects; most impairment was in the postreceptor ...
Jonathan Bogan
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The menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal [PDF]
Human Molecular Genetics, 1999 Menkes disease is an X-linked recessive copper deficiency disorder caused by mutations in the ATP7A ( MNK ) gene which encodes a copper transporting P-type ATPase (MNK). MNK is normally localized pre- dominantly in the trans -Golgi network (TGN); however, when cells are exposed to excessive copper it is rapidly relocalized to the plasma membrane where ...
Michael J. Petris
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2007 Johannes Hell
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2008 Peter S. McPherson
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Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity [PDF]
Leukemia, 2003 Multicenter phase II trials with Gemtuzumab Ozogamicin (GO/Mylotarg), consisting of a CD33 antibody linked to the cytotoxic drug calicheamicin, have shown a 30% overall response rate in relapsed acute myeloid leukemia patients. However, no clear correlation was observed between CD33 expression on leukemic blasts and response to GO therapy.
Inge Jedema +6 more
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Frontiers in Cellular and Infection Microbiology, 2020 Trypanosoma cruzi is the parasite causative of Chagas disease, a highly disseminated illness endemic in Latin-American countries. T. cruzi has a complex life cycle that involves mammalian hosts and insect vectors both of which exhibits different ...
Betiana Nebaí Salassa +6 more
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