Results 31 to 40 of about 3,012,914 (272)

Cytokinin Inhibits Fungal Development and Virulence by Targeting the Cytoskeleton and Cellular Trafficking

mBio, 2021
Cytokinin (CK) is an important plant developmental regulator, having activities in many aspects of plant life and response to the environment. CKs are involved in diverse processes in the plant, including stem cell maintenance, vascular differentiation ...
Rupali Gupta, Gautam Anand, Lorena Pizarro, Dana Laor Bar-Yosef, Neta Kovetz, Noa Sela, Tal Yehuda, Ehud Gazit, Maya Bar   +8 more
doaj   +1 more source

Impact of Endocytosis Mechanisms for the Receptors Targeted by the Currently Approved Antibody-Drug Conjugates (ADCs)—A Necessity for Future ADC Research and Development

Pharmaceuticals, 2021
Biologically-based therapies increasingly rely on the endocytic cycle of internalization and exocytosis of target receptors for cancer therapies. However, receptor trafficking pathways (endosomal sorting (recycling, lysosome localization) and lateral ...
Manar Hammood, Andrew W. Craig, Jeffrey V. Leyton   +2 more
doaj   +1 more source

Elucidation of the Cellular Interactome of African Swine Fever Virus Fusion Proteins and Identification of Potential Therapeutic Targets

Viruses, 2023
African swine fever virus (ASFV) encodes more than 150 proteins, most of them of unknown function. We used a high-throughput proteomic analysis to elucidate the interactome of four ASFV proteins, which potentially mediate a critical step of the infection
Isabel García-Dorival, Miguel Ángel Cuesta-Geijo, Inmaculada Galindo, Ana del Puerto, Lucía Barrado-Gil, Jesús Urquiza, Covadonga Alonso   +6 more
doaj   +1 more source

Kinesin-1 Regulates Endocytic Trafficking of Classical Swine Fever Virus along Acetylated Microtubules

Journal of Virology, 2023
The minus end-directed cytoplasmic dynein and the plus end-directed kinesin-1 are the molecular motors that transport cargo on microtubules in intracellular trafficking, which plays a notable role in the life cycles of diverse viruses.
Jin-xiu Lou, Ya-yun Liu, Jingjing Bai, Yan Cheng, Jin Zhang, Chun-chun Liu, Bin Zhou   +6 more
semanticscholar   +1 more source

Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors

Neurobiology of Disease, 2020
ARFGEF1 encodes a guanine exchange factor involved in intracellular vesicle trafficking, and is a candidate gene for childhood genetic epilepsies. To model ARFGEF1 haploinsufficiency observed in a recent Lennox Gastaut Syndrome patient, we studied a ...
JiaJie Teoh, Narayan Subramanian, Maria Elena Pero, Francesca Bartolini, Ariadna Amador, Ayla Kanber, Damian Williams, Sabrina Petri, Mu Yang, Andrew S. Allen, Jules Beal, Sheryl R. Haut, Wayne N. Frankel   +12 more
doaj   +1 more source

Multifaceted membrane binding head of the SARS-CoV-2 spike protein

Current Research in Structural Biology, 2022
The SARS-CoV-2 spike protein presents a surface with enormous membrane binding potential to host tissues and organelles of infected cells. Its exposed trimeric head binds not only the angiotensin-converting enzyme 2 (ACE2), but also host phospholipids ...
Anh Tran, Troy A. Kervin, Michael Overduin   +2 more
doaj   +1 more source

Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle

bioRxiv, 2023
Regulation of the luminal pH of late endocytic compartments in continuously fed mammalian cells is poorly understood. Using normal rat kidney fibroblasts, we investigated the reversible assembly/disassembly of the proton pumping V-ATPase when ...
Ioana Sava, Luther J. Davis, S. Gray, Nicholas A. Bright, J. P. Luzio   +4 more
semanticscholar   +1 more source

HPV-16 E7 Interacts with the Endocytic Machinery via the AP2 Adaptor μ2 Subunit

mBio, 2022
Despite being a very small protein, HPV-E7 has a wide range of functions within the infected cell, many of which can lead to cell transformation. High-risk HPV-E7 deregulates the function of many cellular proteins, perturbing cellular homeostasis ...
Om Basukala, Oscar Trejo-Cerro, M. Myers, D. Pim, P. Massimi, Miranda Thomas, C. Guarnaccia, D. Owen, L. Banks   +8 more
semanticscholar   +1 more source

Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast

bioRxiv, 2022
Gasdermin D (GSDMD) and mixed lineage kinase domain-like protein (MLKL) are the pore-forming effectors of pyroptosis and necroptosis, respectively, with the capacity to disturb plasma membrane selective permeability and induce programmed cell death.
M. Valenti, M. Molina, V. J. Cid
semanticscholar   +1 more source

Conserved NIMA kinases regulate multiple steps of endocytic trafficking

bioRxiv, 2022
Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint–DNA-damage control (NEK1/2/4/5/10/11), and ciliogenesis (NEK1/4/8).
Braveen B. Joseph, Naava Naslavsky, Shaonil Binti, Sylvia Conquest, Lexi Robison, Ge Bai, Rafael O. Homer, B. Grant, S. Caplan, D. Fay   +9 more
semanticscholar   +1 more source