Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]
, 2016 The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H. +5 more
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Proteomics of secretory and endocytic organelles in Giardia lamblia. [PDF]
PLoS ONE, 2014 Giardia lamblia is a flagellated protozoan enteroparasite transmitted as an environmentally resistant cyst. Trophozoites attach to the small intestine of vertebrate hosts and proliferate by binary fission.
Petra B Wampfler +4 more
doaj +1 more source
Volleying plasma membrane proteins from birth to death: Role of J-domain proteins
Frontiers in Molecular Biosciences, 2022 The function, stability, and turnover of plasma membrane (PM) proteins are crucial for cellular homeostasis. Compared to soluble proteins, quality control of plasma membrane proteins is extremely challenging.
Preeti Sagarika +2 more
doaj +1 more source
From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein [PDF]
, 2012 Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed.
A. Friedman +53 more
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Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts [PDF]
, 2019 Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied.
Nauwynck, Hans +2 more
core +1 more source
Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR
International Journal of Cell Biology, 2011 The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins.
Frederic Delom, Delphine Fessart
doaj +1 more source
Reovirus Cell Entry Requires Functional Microtubules
mBio, 2013 Mammalian reovirus binds to cell-surface glycans and junctional adhesion molecule A and enters cells by receptor-mediated endocytosis in a process dependent on β1 integrin.
Bernardo A. Mainou +5 more
doaj +1 more source
The redox sensor TXNL1 plays a regulatory role in fluid phase endocytosis. [PDF]
PLoS ONE, 2007 BACKGROUND: Small GTPases of the Rab family can cycle between a GTP- and a GDP-bound state and also between membrane and cytosol. The latter cycle is mediated by the Guanine Nucleotide Dissociation Inhibitor GDI, which can selectively extract GDP-bound ...
Michela Felberbaum-Corti +4 more
doaj +1 more source
Wellcome Open Research, 2023 Background: Genome-wide subcellular protein localisation in Trypanosoma brucei, through our TrypTag project, has comprehensively dissected the molecular organisation of this important pathogen. Powerful as this resource is, T.
Richard J. Wheeler +3 more
doaj +1 more source
The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice. [PDF]
, 2012 The PICALM (CALM) gene, whose product is involved in clathrin-mediated endocytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT10 (AF10). We developed a mouse model of CALM-AF10(+) leukemia to examine the
Anastasi, J +5 more
core +2 more sources