Results 71 to 80 of about 64,404 (299)

The Parkinson's disease-associated protein DJ-1 plays a positive nonmitochondrial role in endocytosis in Dictyostelium cells

Disease Models & Mechanisms, 2017
The loss of function of DJ-1 caused by mutations in DJ1 causes a form of familial Parkinson's disease (PD). However, the role of DJ-1 in healthy and in PD cells is poorly understood. Even its subcellular localization in mammalian cells is uncertain, with
Suwei Chen, Sarah J. Annesley, Rasha A. F. Jasim, Vanessa J. Musco, Oana Sanislav, Paul R. Fisher   +5 more
doaj   +1 more source

A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters

Cell Discovery, 2022
The emergence of highly transmissible SARS-CoV-2 variants has led to the waves of the resurgence of COVID-19 cases. Effective antivirals against variants are required.
Hanjun Zhao, Kelvin Kai-Wang To, Hoiyan Lam, Chuyuan Zhang, Zheng Peng, Xinjie Meng, Xiankun Wang, Anna Jinxia Zhang, Bingpeng Yan, Jianpiao Cai, Man Lung Yeung, Jasper Fuk-Woo Chan, Kwok-Yung Yuen   +12 more
doaj   +1 more source

Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae. [PDF]

, 2019
The evolutionarily conserved Target of Rapamycin (TOR) complex-2 (TORC2) is an essential regulator of plasma membrane homeostasis in budding yeast (Saccharomyces cerevisiae).
Locke, Melissa N, Thorner, Jeremy
core   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Porcine Circovirus Type 3 Enters Into PK15 Cells Through Clathrin- and Dynamin-2-Mediated Endocytosis in a Rab5/Rab7 and pH-Dependent Fashion

Frontiers in Microbiology, 2021
Porcine circovirus type 3 (PCV3) invades multiple tissues and organs of pigs of different ages and are widely spread throughout pig farms, emerging as an important viral pathogen that can potentially damage the pig industry worldwide.
Ruihan Shi, Lei Hou, Lei Hou, Lei Hou, Li Wei, Rong Quan, Bin Zhou, Haijun Jiang, Jing Wang, Shanshan Zhu, Jiangwei Song, Dan Wang, Jue Liu, Jue Liu, Jue Liu   +14 more
doaj   +1 more source

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. [PDF]

, 2017
Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft ...
Chang, Ting-Ya, Chang, Ya-Chu, Chen, Chen, Cheng, Pei-Lin, Guo, Chin-Lin, Lee, Min, Lu, Chi-Huan, Lu, Shao-Tzu, Wang, Aijun, Wang, De-Yao   +9 more
core   +2 more sources

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Ubiquitin initiates sorting of Golgi and plasma membrane proteins into the vacuolar degradation pathway

BMC Plant Biology, 2012
Background In yeast and mammals, many plasma membrane (PM) proteins destined for degradation are tagged with ubiquitin. These ubiquitinated proteins are internalized into clathrin-coated vesicles and are transported to early endosomal compartments. There,
Scheuring David, Künzl Fabian, Viotti Corrado, Yan Melody San Wan, Jiang Liwen, Schellmann Swen, Robinson David G, Pimpl Peter   +7 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit

Frontiers in Cellular Neuroscience, 2019
Herpes simplex virus type 1 (HSV-1) is a neurotropic virus able to reach the central nervous system (CNS) after primary infection in oronasal mucosa. HSV-1 establishes latency inside neurons due the repression of its gene expression process, which is ...
Francisca Acuña-Hinrichsen, Mariela Muñoz, Mariela Muñoz, Melissa Hott, Carolina Martin, Evelyn Mancilla, Paula Salazar, Luis Leyton, Angara Zambrano, Angara Zambrano, Margarita I. Concha, Patricia V. Burgos, Patricia V. Burgos, Patricia V. Burgos, Carola Otth, Carola Otth   +15 more
doaj   +1 more source