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Mechanisms of Endocytosis

Annual Review of Biochemistry, 2009
Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins that control these events.
Harvey T Mcmahon
exaly   +3 more sources

Endocytosis of lipoproteins

Atherosclerosis, 2018
During their metabolism, all lipoproteins undergo endocytosis, either to be degraded intracellularly, for example in hepatocytes or macrophages, or to be re-secreted, for example in the course of transcytosis by endothelial cells. Moreover, there are several examples of internalized lipoproteins sequestered intracellularly, possibly to exert ...
Paolo Zanoni   +4 more
openaire   +4 more sources

Adenovirus endocytosis

The Journal of Gene Medicine, 2003
AbstractPathogen entry into cells occurs by direct penetration of the plasma membrane, clathrin‐mediated endocytosis, caveolar endocytosis, pinocytosis or macropinocytosis. For a particular agent, the infectious pathways are typically restricted, reflecting a tight relationship with the host.
Meier, O, Greber, U F
openaire   +6 more sources

Endocytosis at the nanoscale

Chemical Society Reviews, 2012
Endocytosis is a fundamental process in which eukaryotic cells internalise molecules and macromolecules via deformation of the membrane and generation of membrane-bound carriers. Functional aspects are not only limited to uptake of nutrients, but also play a primary role in evolutionary conserved processes such as the regulation of plasma membrane ...
Canton, Irene, Battaglia, Giuseppe
openaire   +2 more sources

Phosphoinositides in endocytosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
The internalization and subsequent endosomal trafficking of proteins and membrane along the endocytic pathway is a fundamental cellular process. Over the last two decades, this pathway has emerged to be subject to extensive regulation by phosphoinositides (PIs), phosphorylated derivatives of the minor membrane phospholipid phosphatidylinositol ...
York Posor   +2 more
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Endocytosis and signaling

Current Opinion in Cell Biology, 2011
Many cellular signaling processes are governed by endocytosis through the internalization of plasma membrane receptors. This receptor clearance defines the quality with which a cell can react to extracellular stimuli. However, growing evidence indicates that endocytosis also enables the formation of endosome-specific signal transduction complexes ...
Harald W, Platta, Harald, Stenmark
openaire   +2 more sources

Endocytosis and cancer

Current Opinion in Cell Biology, 2004
Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface.
S. Polo, S. Pece, P.P. Di Fiore
openaire   +3 more sources

Endocytosis in enterocytes

Wiener Medizinische Wochenschrift, 2016
Endocytosis is a fundamental cell biological process, which carries out essential functions in a polarized epithelial cell such as enterocytes provided with a huge surface area of the brush border membrane. Major tasks of enterocytes, which are regulated by endocytic signals, are digestion and absorption of nutrients and drugs/pharmacological agents ...
Klaus-Peter, Zimmer   +3 more
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