Results 41 to 50 of about 73,519 (232)

Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases [PDF]

BioMed Research International, 2017
At least 8% of the human genome is composed of endogenous retrovirus (ERV) sequences. ERVs play a role in placental morphogenesis and can sometimes protect the host against exogenous viruses. On the other hand, ERV reactivation has been found to be associated with different diseases, for example, multiple sclerosis (MS), schizophrenia, type 1 diabetes ...
Christine Brütting, Alexander Emmer, Malte E. Kornhuber, Martin S. Staege   +3 more
openaire   +2 more sources

Investigation of Endogenous Retrovirus Sequences in the Neighborhood of Genes Up-regulated in a Neuroblastoma Model after Treatment with Hypoxia-Mimetic Cobalt Chloride

Frontiers in Microbiology, 2018
Human endogenous retroviruses (ERVs) have been found to be associated with different diseases, e.g., multiple sclerosis (MS). Most human ERVs integrated in our genome are not competent to replicate and these sequences are presumably silent.
Christine Brütting, Christine Brütting, Harini Narasimhan, Frank Hoffmann, Malte E. Kornhuber, Martin S. Staege, Alexander Emmer   +6 more
doaj   +1 more source

FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]

, 2018
FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang, Wang, Qun, Zhou, Baohua, Ziegler, Steven F.   +3 more
core   +1 more source

Human Endogenous Retrovirus-like Sequences

, 1989
One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed “provirus”, can then serve as a template for the synthesis of further infectious virus particles ...
Brack-Werner, R., Leib-Mösch, C., Werner, T., Erfle, V.F., Hehlmann, R.   +4 more
openaire   +3 more sources

Genomic Flexibility of Human Endogenous Retrovirus Type K [PDF]

Journal of Virology, 2013
ABSTRACT Human endogenous retrovirus type K (HERV-K) proviruses are scattered throughout the human genome, but as no infectious HERV-K virus has been detected to date, the mechanism by which these viruses replicated and populated the genome remains unresolved.
Dube, Derek, Contreras-Galindo, Rafael, He, Shirley, King, Steven, Gonzalez-Hernandez, Marta, Gitlin, Scott, Kaplan, Mark, Markovitz, David   +7 more
openaire   +3 more sources

Amplification of simian retroviral sequences from human recipients of baboon liver transplants [PDF]

, 1998
Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases ...
Anonymous, ANTHONY G. COMUZZIE, EVELYN M. WHITEHEAD, JONATHAN S. ALLAN, KAREN L. LEIGHTON, M. MICHELLE LELAND, MARIAN G. MICHAELS, ROBERT E. LANFORD, SUZANNE R. BROUSSARD, THOMAS E. STARZL, van der Kuyl AC, WALID HENEINE, WILLIAM M. SWITZER   +12 more
core   +1 more source

Domestic chickens activate a piRNA defense against avian leukosis virus [PDF]

, 2017
PIWI-interacting RNAs (piRNAs) protect the germ line by targeting transposable elements (TEs) through the base-pair complementarity. We do not know how piRNAs co-evolve with TEs in chickens.
Anai, Aravin, Aravin, Aravin, Assis, Baluda, Bao, Bartel, Benkel, Bolisetty, Boyce-Jacino, Boyce-Jacino, Brawand, Brennecke, Carmell, Cenik, Cenik, Chen, Chirn, Crittenden, Dempster, Eickbush, Eriksson, Fadly, Fagegaltier, Farazi, Feschotte, Flemr, Frisby, Frost, Gao, Ghildiyal, Gifford, Goic, Gunawardane, Guo, Haas, Han, Hayward, Houwing, Houwing, Ingolia, Ingolia, International Chicken Genome Sequencing Consortium, Johnson, Jurka, Ka, Ka, Khurana, Kim, Kohany, Kojima, Kuhnlein, Kumar, Kumar, Kuramochi-Miyagawa, Kuramochi-Miyagawa, Lee, Levin, Lewinski, Li, Li, Li, Lim, Lin, Lu, Malik, Malone, McClintock, Meunier, Moore, Nawrocki, Necsulea, Oh, Paradis, Peirson, Pelechano, Reuter, Reuter, Ricci, Roberts, Robinson, Rosenkranz, Rutherford, Sacco, Saxe, Schlötterer, Shoji, Smit, Smith, Smith, Smith, Smith, Soper, Stehelin, Steitz, Stoye, Sumiyoshi, Tam, Tanaka, Tarlinton, Team, Temin, Tereba, Thompson, Thomson, Trapnell, Trapnell, Vandergon, Varmus, Wang, Wang, Watanabe, Weiss, Weiss, Weiss, West, Wichert, Wicker, Wilson, Yabuta, Zhang, Zhang, Zheng, Zhuang   +124 more
core   +2 more sources

Arc – An endogenous neuronal retrovirus?

Seminars in Cell & Developmental Biology, 2018
The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and has been implicated in various neurological disorders. However, little is known about Arc's evolutionary origins. Recent studies suggest that mammalian Arc originated from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to ...
openaire   +3 more sources

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

Nature Communications
The development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hypothesized ...
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Carole Zaratiegui, Hin-Man Tai, Gabriele Ciceri, Ina Rothenaigner, Jason Tchieu, Brent R. Stockwell, Lorenz Studer, Daphne S. Cabianca, Michael P. Menden, Michelle Vincendeau, Kamyar Hadian   +13 more
doaj   +1 more source