Results 101 to 110 of about 603,777 (298)

m6A RNA methylation regulates the fate of endogenous retroviruses

bioRxiv, 2020
Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that impact genome regulation and cell physiology throughout their RNA-centered life cycle1.
Tomasz Chelmicki, Emeline Roger, Aurélie Teissandier, Sofia Rucli, François Dossin, Mathilde Dura, C. Fouassier, S. Lameiras, D. Bourc’his   +8 more
semanticscholar   +1 more source

Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes

Arthritis &Rheumatology, Accepted Article.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López, Carlos Rangel‐Peláez, Inmaculada Rodriguez‐Martin, Alfredo Guillen‐Del‐Castillo, Carmen P Simeón‐Aznar, José L Callejas, International SSc Group; PRECISESADs Clinical Consortium, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), Nicolas Hunzelmann, Gianluca Moroncini, Jeska K de Vries‐Bouwstra, Ariane L Herrick, Yannick Allanore, Marta E. Alarcon‐Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P Denton, Maureen D Mayes, Javier Martin, Marialbert Acosta‐Herrera, Martin Kerick   +23 more
wiley   +1 more source

Human Endogenous Retroviruses

International Journal of Innovative Approaches in Science Research, 2018
Human Endogenous retroviruses (HERVs) occupy nearly 8% of human genome. They are thought to be remnants of retroviruses.  These integrated elements have gag, pol and env coding regions. The genome order of 5 ’LTR-gag-pro-pol-env-LTR 3’ is completely conserved among known retroviruses and endogenous retroviruses. A complete LTRs consists of untranslated
Buket Çakmak Güner, Nermin Gözükırmızı   +1 more
openaire   +1 more source

An endogenous foamy-like viral element in the coelacanth genome. [PDF]

PLoS Pathogens, 2012
Little is known about the origin and long-term evolutionary mode of retroviruses. Retroviruses can integrate into their hosts' genomes, providing a molecular fossil record for studying their deep history.
Guan-Zhu Han, Michael Worobey
doaj   +1 more source

Transposable Elements, Inflammation, and Neurological Disease. [PDF]

, 2019
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela, Muotri, Alysson R, Saleh, Aurian   +2 more
core  

Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada [PDF]

, 2014
The 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses was held in Montreal, Québec from June 26 to June 30, 2013 and was therefore hosted by a Canadian city for the first time.
Barbeau, Benoit, Bazarbachi, Ali, Carvalho, Edgar, Hiscott, John, Jones, Kathryn, Martin, Fabiola, Matsuoka, Masao, Murphy, Edward L, Ratner, Lee, Switzer, William M, Watanabe, Toshiki   +10 more
core   +4 more sources

Silencing and Transcriptional Regulation of Endogenous Retroviruses: An Overview

Viruses, 2020
Almost half of the human genome is made up of transposable elements (TEs), and about 8% consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous retrovirus infections of the germ line.
Franziska K. Geis, S. Goff
semanticscholar   +1 more source

Automation of an integrated micro‐scale platform for monoclonal antibody process development by incorporation of a depth filter mimic

Biotechnology Progress, EarlyView.
Integrating non‐chromatographic operations, such as low pH viral inactivation and a depth filtration mimic, into an automated micro‐scale platform enhances productivity while reducing resource and time requirements. By facilitating rapid, data‐rich experimentation, the platform offers a powerful and efficient tool for assessing and optimizing ...
Paras Sharma, Petra Sebastian, Lars Robbel, Michael Schmitt, Daniel G. Bracewell   +4 more
wiley   +1 more source

Endogenous retroviruses of the chicken genome

Biology Direct, 2008
We analyzed the chicken (Gallus gallus) genome sequence to search for previously uncharacterized endogenous retrovirus (ERV) sequences using ab initio and combined evidence approaches.
Jordan I King, Polavarapu Nalini, Huda Ahsan, McDonald John F   +3 more
doaj   +1 more source

Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis [PDF]

, 2017
The human genome displays a rich fossil record of past gamma-retrovirus infections, yet no current epidemic is evident, despite environmental exposure to viruses that infect human cells in vitro.
Ahmad, Shamim, Cameron, Ewan, Kilbey, Anna, Levy, Laura S., Mackay, Nancy, Naseer, Asif, Neil, James C., Terry, Anne, Watts, Ciorsdaidh, Wilson, Sam   +9 more
core   +1 more source