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Endogenous retroviruses and schizophrenia
Brain Research Reviews, 2000Retroviruses are biologically complex infectious agents which are capable of cellular infection and subsequent integration into the host genome. Retroviruses can exist in an endogenous form in which viral sequences are integrated into the human germline and are vertically transmitted in a Mendelian fashion. The transcriptional activation of these viral
Håkan Karlsson +2 more
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[Endogenous porcine retroviruses and xenotransplantation].
Pathologie-biologie, 2000 Vertebrate DNA contains numerous genomes closely related to retroviruses, i.e. endogenous retroviruses. While most of the retroviruses are pathogenous, endogenous retroviruses have rarely been shown as such. Endogenous retroviruses, as most of the retroviruses, are able to cross 'species barriers'. Porcine endogenous retroviruses were described in 1974.
Mornex, Jean-Francois
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Endogenous retroviruses and the human germline
Current Opinion in Genetics and Development, 2000The human genome is rife with the proviral remains of many ancient retroviruses. The past year has seen significant progress in understanding the structure, distribution and potential function of many of these elements. Although hypotheses concerning the potential effects of these elements are common, however, incisive experiments to test any functions
Michael Böck, Jonathan Stoye
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BioEssays, 1988
AbstractSeveral studies have revealed the presence in human DNA of thousands of endogenous retrovirus genomes, or HERVs. Many HERVs are related to extant retroviruses that infect other vertebrates and some have been present in the germ line of primates for millions of years.
M, Cohen, E, Larsson
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AbstractSeveral studies have revealed the presence in human DNA of thousands of endogenous retrovirus genomes, or HERVs. Many HERVs are related to extant retroviruses that infect other vertebrates and some have been present in the germ line of primates for millions of years.
M, Cohen, E, Larsson
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Endogenous Retroviruses in Xenografts
New England Journal of Medicine, 1993To the Editor: Pressed by the increasing shortage of human organs, we are rapidly moving toward the use of xenografts from pigs or nonhuman primates. We must ask whether endogenous animal retroviruses pose any public health risk when transplanted into a human host.
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Endogenous retroviruses and animal reproduction
Cytogenetic and Genome Research, 2005Endogenous retroviruses (ERV), as part of the host genetic heritage, are transmissible to the next generation in a Mendelian way. Their abundance in animal genomes and their expression primarily detected in germ cells, embryonic tissues and cancer cell lines, raised the question of their biological significance.
S, Prudhomme, B, Bonnaud, F, Mallet
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Human Endogenous Retroviruses in Diseases
2023Human endogenous retroviruses (HERVs), which are conserved sequences of ancient retroviruses, are widely distributed in the human genome. Although most HERVs have been rendered inactive by evolution, some have continued to exhibit important cytological functions.
Tian-Jiao, Fan, Jie, Cui
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Pig endogenous retroviruses and xenotransplantation
Xenotransplantation, 2002Xenotransplantation of porcine organs might provide an unlimited source of donor organs to treat endstage organ failure diseases in humans. However, pigs harbour retroviruses with unknown pathogenic potential as an integral part of their genome. While until recently the risk of interspecies transmission of these porcine endogenous retroviruses (PERV ...
Jürgen H, Blusch +2 more
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Silencing of endogenous retroviruses by heterochromatin
Cellular and Molecular Life Sciences, 2017Endogenous retroviruses (ERV) are an abundant class of repetitive elements in mammalian genomes. To ensure genomic stability, ERVs are largely transcriptionally silent. However, these elements also feature physiological roles in distinct developmental contexts, under which silencing needs to be partially relieved.
Sophia Groh, Gunnar Schotta
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Human endogenous retroviruses and ADHD
The World Journal of Biological Psychiatry, 2013Several lines of evidences suggest that human endogenous retroviruses (HERVs) are implicated in the development of many complex diseases with a multifactorial aetiology and a strong heritability, such as neurological and psychiatric diseases. Attention deficit hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that results from a complex ...
BALESTRIERI, EMANUELA +11 more
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