Results 141 to 150 of about 10,232 (247)

Characterization of a Thermostable Endolysin of the Aeribacillus Phage AeriP45 as a Potential Staphylococcus Biofilm-Removing Agent

Viruses
Multidrug-resistant Gram-positive bacteria, including bacteria from the genus Staphylococcus, are currently a challenge for medicine. Therefore, the development of new antimicrobials is required.
N. Golosova, Y. Khlusevich, Vera V. Morozova, A. Matveev, Yulia N. Kozlova, A. Tikunov, E. A. Panina, Nina V. Tikunova   +7 more
semanticscholar   +1 more source

Novel endolysin

, 2018
The present invention relates to a polypeptide with endolysin activity and amino acid sequences according to SEQ ID No. 1 and fragments or derivatives thereof. Moreover, the present invention relates to nucleic acid molecules encoding said polypeptide, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid ...
Oliveira, Hugo Alexandre Mendes, Azeredo, Joana   +1 more
openaire   +1 more source

Effective Removal of Staphylococcal Biofilms by the Endolysin LysH5

PLoS ONE, 2014
Staphylococcal biofilms are a major concern in both clinical and food settings because they are an important source of contamination. The efficacy of established cleaning procedures is often hindered due to the ability of some antimicrobial compounds to induce biofilm formation, and to the presence of persister cells, a small bacterial subpopulation ...
Diana Gutiérrez, Patricia Ruas-Madiedo, Beatriz Martínez, Ana Rodríguez, Pilar García   +4 more
openaire   +5 more sources

Endolysins: a new antimicrobial agent against antimicrobial resistance. Strategies and opportunities in overcoming the challenges of endolysins against Gram-negative bacteria

Frontiers in Pharmacology
Antibiotic-resistant bacteria are rapidly emerging, and the increasing prevalence of multidrug-resistant (MDR) Acinetobacter baumannii poses a severe threat to humans and healthcare organizations, due to the lack of innovative antibacterial drugs ...
Fazal Mehmood Khan, Fazal Mehmood Khan, Fazal Rasheed, Yunlan Yang, Bin Liu, Rui Zhang, Rui Zhang   +6 more
doaj   +1 more source

Towards Inhaled Phage Therapy in Western Europe [PDF]

, 2019
The emergence of multidrug-resistant bacteria constitutes a great challenge for modern medicine, recognized by leading medical experts and politicians worldwide.
Lienau, Jasmin, Wienhold, Sandra-Maria, Witzenrath, Martin   +2 more
core   +1 more source

Bacteriophage Endolysins as a Novel Class of Antibacterial Agents

Experimental Biology and Medicine, 2006
Endolysins are double-stranded DNA bacteriophage-encoded peptidoglycan hydrolases produced in phage-infected bacterial cells toward the end of the lytic cycle. They reach the peptidoglycan through membrane lesions formed by holins and cleave it, thus, inducing lysis of the bacterial cell and enabling progeny virions to be released. Endolysins are also
Jan, Borysowski, Beata, Weber-Dabrowska, Andrzej, Górski   +2 more
openaire   +2 more sources

Extraction, Purification and Therapeutic Use of Bacteriophage Endolysin against Multi-Drug Resistant Staphylococcus aureus: in-vivo and in-vitro study

Journal of Contemporary Medical Sciences, 2018
Objectives: Isolation of endolysin from Staphylococcus aureus bacteriophages, and administering them systemic In vivo lab animal and measure the therapeutic efficacy as well as evaluation of their biosafety. Method: This study was performed from March
Mohammed R. Ali, Ahmed S. Abdulamir, Shurooq R. Kadhim   +2 more
doaj  

Ts2631 Endolysin from the Extremophilic Thermus scotoductus Bacteriophage vB_Tsc2631 as an Antimicrobial Agent against Gram-Negative Multidrug-Resistant Bacteria

Viruses, 2019
Bacteria that thrive in extreme conditions and the bacteriophages that infect them are sources of valuable enzymes resistant to denaturation at high temperatures.
Magdalena Plotka, Malgorzata Kapusta, Sebastian Dorawa, Anna-Karina Kaczorowska, Tadeusz Kaczorowski   +4 more
doaj   +1 more source

Potential therapeutic application of bacteriophages and phage-derived endolysins as alternative treatment of bovine mastitis [PDF]

, 2018
The increase in bacterial drug resistance causes major difficulties in the clinical treatment of a growing number of bacterial infections worldwide.
Meyer, Evelyne, Vander Elst, Niels
core  

Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases. [PDF]

, 2010
Dipeptidyl-peptidase VI from Bacillus sphaericus and YkfC from Bacillus subtilis have both previously been characterized as highly specific γ-D-glutamyl-L-diamino acid endopeptidases. The crystal structure of a YkfC ortholog from Bacillus cereus (BcYkfC)
Abdubek, Polat, Astakhova, Tamara, Axelrod, Herbert L, Bakolitsa, Constantina, Cai, Xiaohui, Carlton, Dennis, Chen, Connie, Chiu, Hsiu Ju, Chiu, Michelle, Clayton, Thomas, Das, Debanu, Deacon, Ashley M, Deller, Marc C, Duan, Lian, Ellrott, Kyle, Elsliger, Marc André, Farr, Carol L, Feuerhelm, Julie, Godzik, Adam, Grant, Joanna C, Grzechnik, Anna, Han, Gye Won, Hodgson, Keith O, Jaroszewski, Lukasz, Jin, Kevin K, Klock, Heath E, Knuth, Mark W, Kozbial, Piotr, Krishna, S Sri, Kumar, Abhinav, Lam, Winnie W, Lesley, Scott A, Marciano, David, Miller, Mitchell D, Morse, Andrew T, Nigoghossian, Edward, Nopakun, Amanda, Okach, Linda, Puckett, Christina, Reyes, Ron, Tien, Henry J, Trame, Christine B, van den Bedem, Henry, Weekes, Dana, Wilson, Ian A, Wooley, John, Wooten, Tiffany, Xu, Qingping, Yeh, Andrew   +48 more
core   +3 more sources