Results 121 to 130 of about 8,598 (217)
Genome sequence of the temperate bacteriophage PH10 from Streptococcus oralis [PDF]
, 2018 Exponential growing cultures of Streptococcus oralis strain OMZ 1038, isolated from human supragingival dental plaque, were found to release a bacteriophage (designated PH10) upon treatment with mitomycin C. The complete genome sequence of phage PH10 was
van der Ploeg, Jan
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Fermentation Practices Select for Thermostable Endolysins in Phages
Molecular Biology and EvolutionAbstract Endolysins are produced by (bacterio)phages and play a crucial role in degrading the bacterial cell wall and the subsequent release of new phage progeny. These lytic enzymes exhibit a remarkable diversity, often occurring in a multimodular form that combines different catalytic and cell wall-binding domains, even in phages ...
Frank Oechslin +5 more
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Phage endolysins: Structure, function and applications
Science and Technology Development Journal-Natural SciencesAntibiotic resistance has emerged and persisted as one of the major threats to public health and the sustainable development of healthcare systems worldwide in recent years. The primary reason why antibiotic resistance is regarded as a global medical crisis lies in the development of new antibiotics is not keeping pace with the emergence of antibiotic ...
Yen-Vy Le-Nguyen, Hieu Tran-Van
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Frontiers in PharmacologyAntibiotic-resistant bacteria are rapidly emerging, and the increasing prevalence of multidrug-resistant (MDR) Acinetobacter baumannii poses a severe threat to humans and healthcare organizations, due to the lack of innovative antibacterial drugs ...
Fazal Mehmood Khan +6 more
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Distribution and composition of the lysis cassette of Lactococcus lactis phages and functional analysis of bacteriophage ul36 holin [PDF]
, 2017 The bacteriophage lysis cassette, which comprises a lysin and a holin gene, was analyzed in 18 Lactococcus lactis phages. A muramidase motif was found in the lysins of c2-like phages, while an amidase motif was observed in the lysins of 936-like phages ...
Labrie, Steve +3 more
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Gram-negative endolysins: overcoming the outer membrane obstacle
Current Opinion in MicrobiologyOur ability to control the growth of Gram-negative bacterial pathogens is challenged by rising antimicrobial resistance and requires new approaches. Endolysins are phage-derived enzymes that degrade peptidoglycan and therefore offer potential as antimicrobial agents.
Hazel M, Sisson +4 more
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Inhaled endolysin therapy for bacterial infections
, 2023 Antimicrobial peptides and proteins (APPs) are becoming increasingly important in targeting multidrug-resistant (MDR) bacteria. Inhalation delivery of these agents can be an effective treatment of respiratory infections owing to the high local drug concentration in the lungs.
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Molecular Therapy: Nucleic AcidsEndolysins are bacteriophage-encoded hydrolases that show high antibacterial activity and a narrow substrate spectrum. We hypothesize that an mRNA-based approach to endolysin therapy can overcome some challenges of conventional endolysin therapy, namely ...
Moritz K. Jansson +7 more
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mBioStreptococcus pneumoniae (Spn), a Gram-positive bacterium, is responsible for causing a wide variety of invasive infections. The emergence of multi-drug antibiotic resistance has prompted the search for antimicrobial alternatives.
Adit B. Alreja +5 more
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Endolysins are hidden out there
, 2018 Trabajo presentado en el 2nd International Symposium on Antimicrobial Hydrolytic Enzymes, celebrado en Nueva York (Estados Unidos), del 6 al 8 de noviembre de 2018 Peer ...
Gutiérrez, Diana +4 more
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