Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails [PDF]
Scientific Reports, 2022 The application of bacteriophages as antibacterial agents has many benefits in the “post-antibiotic age”. To increase the number of successfully targeted bacterial strains, phage cocktails, instead of a single phage, are commonly formulated. Nevertheless,
Miguel A Vega-Rodríguez +2 more
exaly +8 more sources
Phage Cocktails Constrain the Growth of Enterococcus [PDF]
mSystems, 2022 Phages that infect pathogenic bacteria present a valuable resource for treating antibiotic-resistant infections. We isolated and developed a collection of 19 Enterococcus phages, including myoviruses, siphoviruses, and a podovirus, that can infect both ...
Stephen Wandro +8 more
doaj +8 more sources
Metagenomic Analysis of Therapeutic PYO Phage Cocktails from 1997 to 2014 [PDF]
Viruses, 2017 Phage therapy has regained interest in recent years due to the alarming spread of antibiotic resistance. Whilst phage cocktails are commonly sold in pharmacies in countries such as Georgia and Russia, this is not the case in western countries due to ...
Morten Nielsen, Mogens Kilstrup
exaly +6 more sources
In Vitro Design and Evaluation of Phage Cocktails Against Aeromonas salmonicida [PDF]
Frontiers in Microbiology, 2018 As an alternative approach against multidrug-resistant bacterial infections, phages are now being increasingly investigated as effective therapeutic agents.
Liu Quan, Yingfei Ma, Guoqin Mai
exaly +7 more sources
Efficacy of Lytic Phage Cocktails on Staphylococcus aureus and Pseudomonas aeruginosa in Mixed-Species Planktonic Cultures and Biofilms [PDF]
Viruses, 2020 The efficacy of phages in multispecies infections has been poorly examined. The in vitro lytic efficacies of phage cocktails AB-SA01, AB-PA01, which target Staphylococcus aureus and Pseudomonas aeruginosa, respectively, and their combination against ...
Legesse Garedew Kifelew +6 more
doaj +3 more sources
Design of Lytic Phage Cocktails Targeting Salmonella: Synergistic Effects Based on In Vitro Lysis, In Vivo Protection, and Biofilm Intervention [PDF]
VirusesSalmonella is a major zoonotic pathogen and phage cocktails offer a novel strategy against its infections. This study aimed to characterize Salmonella phages and assess the efficacy of various phage combinations, both in vitro and in vivo.
Mengrui Zhang +12 more
doaj +3 more sources
A New Pipeline for Designing Phage Cocktails Based on Phage-Bacteria Infection Networks [PDF]
Frontiers in Microbiology, 2021 In recent years, the spread of antibiotic-resistant bacteria and efforts to preserve food microbiota have induced renewed interest in phage therapy. Phage cocktails, instead of a single phage, are commonly used as antibacterial agents since the hosts are unlikely to become resistant to several phages simultaneously. While the spectrum of activity might
Rafael Tabla +2 more
exaly +6 more sources
Comparison of bacterial suppression by phage cocktails, dual‐receptor generalists, and coevolutionarily trained phages [PDF]
Evolutionary Applications, 2023 The evolution and spread of antibiotic‐resistant bacteria have renewed interest in phage therapy, the use of bacterial viruses (phages) to combat bacterial infections.
Joshua M. Borin +3 more
doaj +4 more sources
Phage cocktails: state-of-the-art technologies and strategies for effective design [PDF]
FEMS Microbiology ReviewsAbstract With the growing severity of antimicrobial resistance (AMR), phage therapy has garnered attention as a novel therapeutic alternative. In particular, phage cocktails, which combine multiple phages, potentially offer broader antimicrobial spectra than single-phage applications and may suppress the emergence of resistant ...
Satoshi Tsuneda, Tomoyoshi Kaneko
exaly +4 more sources
Formulation of phage cocktails and evaluation of their interaction with antibiotics in inhibiting carbapenemase-producing Klebsiella pneumoniae in vitro in Kenya [PDF]
African Journal of Laboratory Medicine, 2022 Background: The development of alternative control measures, such as phage therapy or adjunctive therapy, is urgently needed to manage the dissemination of carbapenemase-producing Klebsiella pneumoniae.
Noutin F. Michodigni +5 more
doaj +2 more sources