Results 1 to 10 of about 149,596 (212)

Comparative analysis of phage cocktail activity against uropathogenic E. coli strains using spot overlay assay

MethodsX
Spot overlay assays are a common method for measuring phage activity against target microorganisms and determining % host range activity. Dilutions of phage demonstrate activity by creating a zone of clearing indicative of bacterial killing; however ...
Steven Arcidiacono, Robert Stote
doaj   +1 more source

Phage Therapy: Targeting the Gut Microbiota for the Treatment of Acute Pancreatitis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Acute pancreatitis (AP) is a common clinical inflammatory condition whose severity is closely associated with both local pancreatic injury and systemic complications. Research indicates that gut microbiota dysbiosis and subsequent bacterial translocation can exacerbate disease progression via the gut–pancreas axis, representing a critical ...
Jiawei Chen, Caihan Duan, Keyi Zhang, Jun Liu, Chaoqun Han   +4 more
wiley   +1 more source

Bacteriophage-resistant mutants in Yersinia pestis: identification of phage receptors and attenuation for mice. [PDF]

PLoS ONE, 2011
BACKGROUND: Bacteriophages specific for Yersinia pestis are routinely used for plague diagnostics and could be an alternative to antibiotics in case of drug-resistant plague.
Andrey A Filippov, Kirill V Sergueev, Yunxiu He, Xiao-Zhe Huang, Bryan T Gnade, Allen J Mueller, Carmen M Fernandez-Prada, Mikeljon P Nikolich   +7 more
doaj   +1 more source

Phenotypic and genotypic variations within a single bacteriophage species [PDF]

, 2011
Background Although horizontal gene transfer plays a pivotal role in bacteriophage evolution, many lytic phage genomes are clearly shaped by vertical evolution.
Pieter-Jan Ceyssens, Thea Glonti, ndrew M Kropinski, Rob Lavigne, Nina Chanishvili, Leonid Kulakov, Nino Lashkhi, Marina Tediashvili, Maya Merabishvili   +8 more
core   +2 more sources

Psyllid Cysteine Cathepsins Directly Cleave the Outer Membrane Protein BamD of Citrus Huanglongbing Pathogen

Plant Biotechnology Journal, EarlyView.
ABSTRACT Candidatus Liberibacter asiaticus (CLas), the causative agent of citrus Huanglongbing (HLB), is transmitted by Asian citrus psyllid, Diaphorina citri; however, the role of the insect's immune effectors in defending against CLas remains poorly understood. This study reveals that D.
Yu Du, Yu Bin, Jinhua Yang, Manman Hu, Liqin Jiang, Qiaoling Su, Shiyi Lin, Lanfeng Qu, You Li, Taiyun Wei   +9 more
wiley   +1 more source

Multi-strain phage induced clearance of bacterial infections.

PLoS Computational Biology
Bacteriophage (or 'phage' - viruses that infect and kill bacteria) are increasingly considered as a therapeutic alternative to treat antibiotic-resistant bacterial infections.
Jacopo Marchi, Chau Nguyen Ngoc Minh, Laurent Debarbieux, Joshua S Weitz   +3 more
doaj   +1 more source

Three Novel Bacteriophages for the Biocontrol of Pseudomonas syringae pv. actinidiae on Artificially Contaminated Kiwifruit Leaves

Pathogens
This study compared the efficacy of three individual lytic phages, PSA_LMAPSA-2T (PSA-2T), PSA_LMAPSA-6F (PSA-6F) and PSA_LMAPSA-7F (PSA-7F) and four phage cocktails (dual and triple combinations) in inactivating Pseudomonas syringae pv.
Carla Pereira, Eduardo Gomes, Pedro Costa, João Duarte, Márcia Braz, Vanessa Oliveira, Newton C. M. Gomes, Victor M. Balcão, Adelaide Almeida   +8 more
doaj   +1 more source

Synergistic Interaction Between Phage Therapy and Antibiotics Clears Pseudomonas Aeruginosa Infection in Endocarditis and Reduces Virulence. [PDF]

, 2017
Increasing antibiotic resistance warrants therapeutic alternatives. Here we investigated the efficacy of bacteriophage-therapy (phage) alone or combined with antibiotics against experimental endocarditis (EE) due to Pseudomonas aeruginosa, an archetype ...
Entenza, J.M., Gabard, J., Mancini, S., Moreillon, P., Oechslin, F., Piccardi, P., Que, Y.A., Resch, G.   +7 more
core   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

The Antibacterial Activity of Novel Bacteriophages and the Emergence of Bacterial Resistance to Phage Infections: An In Vitro Study

Applied Biosciences
The emergence of bacteria resistant to bacteriophage (phage) infection may compromise the success and effectiveness of phage therapy. The aim of this study was to evaluate the in vitro antibacterial activity of five novel phages, as well as the emergence
Letícia de Souza Moda-Silva, Viviane de Cássia Oliveira, Tatiana Areas da Cruz, Amanda Carolina Souza Delfino da Rocha, Evandro Watanabe   +4 more
doaj   +1 more source