A New Pipeline for Designing Phage Cocktails Based on Phage-Bacteria Infection Networks [PDF]
Frontiers in Microbiology, 2021 In recent years, the spread of antibiotic-resistant bacteria and efforts to preserve food microbiota have induced renewed interest in phage therapy. Phage cocktails, instead of a single phage, are commonly used as antibacterial agents since the hosts are unlikely to become resistant to several phages simultaneously. While the spectrum of activity might
Rafael Tabla +2 more
exaly +6 more sources
Synergistic effects of halo-plaque forming phage cocktails against polymicrobial Acinetobacter baumannii and Staphylococcus aureus [PDF]
Microbiology SpectrumAntimicrobial resistance is a growing global health crisis, with polymicrobial infections caused by Acinetobacter baumannii and Staphylococcus aureus posing a significant healthcare challenge due to their synergistic virulence, multidrug resistance, high
Ampapan Naknaen +9 more
doaj +2 more sources
Synergy as a rationale for phage therapy using phage cocktails [PDF]
PeerJ, 2014 Where phages are used to treat bacterial contaminations and infections, multiple phages are typically applied at once as a cocktail. When two or more phages in the cocktail attack the same bacterium, the combination may produce better killing than any ...
Matthew Schmerer +2 more
doaj +5 more sources
Phenotypic heterogeneity shapes phage resistance and cocktail efficacy in Klebsiella pneumoniae [PDF]
Microbiology SpectrumThe emergence of phage-resistant bacteria poses a significant challenge to the success of phage therapy. Although phage cocktails can delay resistance, their efficacy relies on the ability to target the full spectrum of resistant variants, which are ...
Lucas Mora-Quilis +2 more
doaj +2 more sources
Phage cocktail strategies for the suppression of a pathogen in a cross‐feeding coculture [PDF]
Microbial Biotechnology, 2020 Summary Cocktail combinations of bacteria‐infecting viruses (bacteriophages) can suppress pathogenic bacterial growth. However, predicting how phage cocktails influence microbial communities with complex ecological interactions, specifically cross ...
Lisa Fazzino +3 more
doaj +3 more sources
A mechanism-based pathway toward administering highly active N-phage cocktails [PDF]
Frontiers in Microbiology, 2023 Dwayne Roach +2 more
exaly +2 more sources
Single Treatment of Mature 3D Single-, Dual- and Poly-Species Biofilms Using a Combination Therapy of Phage or Phage-Hetero-Cocktails and Ciprofloxacin [PDF]
AntibioticsBackground/Objectives: Biofilms are a form of defense that enables bacteria to withstand antibiotic pressure and demonstrate antibiotic resistance. It is crucial to develop anti-biofilm strategies in order to combat chronic and persistent multidrug ...
Tea Glonti +6 more
doaj +2 more sources
Phage cocktails: state-of-the-art technologies and strategies for effective design [PDF]
FEMS Microbiology ReviewsSatoshi Tsuneda +2 more
exaly +2 more sources
Viruses, 2023 Phage therapy of ventilator-associated pneumonia (VAP) is of great interest due to the rising incidence of multidrug-resistant bacterial pathogens. However, natural or therapy-induced immunity against therapeutic phages remains a potential concern.
Chantal Weissfuss +16 more
doaj +1 more source
Microbiology Spectrum, 2022 The rapid emergence of phage-resistant bacterial mutants is a major challenge for phage therapy. Phage cocktails have been considered one approach to mitigate this issue.
Dongyang Gao +9 more
doaj +1 more source