Results 11 to 20 of about 69,713 (182)

Development of Phage Cocktails to Treat E. coli Catheter-Associated Urinary Tract Infection and Associated Biofilms [PDF]

Frontiers in Microbiology, 2022
High rates of antimicrobial resistance and formation of biofilms makes treatment of Escherichia coli catheter-associated urinary tract infections (CAUTI) particularly challenging.
Belkys C. Sanchez, Emmaline R. Heckmann, Sabrina I. Green, Justin R. Clark, Heidi B. Kaplan, Robert F. Ramig, Kenneth L. Muldrew, Kenneth L. Muldrew, Kenneth L. Muldrew, Casey Hines-Munson, Felicia Skelton, Felicia Skelton, Barbara W. Trautner, Barbara W. Trautner, Barbara W. Trautner, Anthony W. Maresso   +15 more
doaj   +4 more sources

Systematic combinatorial optimization of three-phage cocktails against multidrug-resistant Pseudomonas aeruginosa [PDF]

Microbiology Spectrum
Multidrug-resistant (MDR) Pseudomonas aeruginosa poses a significant global health threat, necessitating alternative therapeutic strategies. Bacteriophage therapy shows promise, but single-phage use is prone to resistance.
Meshack Tweya Omwega, Moses Gachoya, Justin Nyasinga, Martin Georges, Collins Kigen, Kevin Kamanyi, Samuel Nyamweya, Erick Odoyo, Lillian Musila   +8 more
doaj   +2 more sources

Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice

Viruses, 2023
Phage therapy of ventilator-associated pneumonia (VAP) is of great interest due to the rising incidence of multidrug-resistant bacterial pathogens. However, natural or therapy-induced immunity against therapeutic phages remains a potential concern.
Chantal Weissfuss, Sandra-Maria Wienhold, Magdalena Bürkle, Baptiste Gaborieau, Judith Bushe, Ulrike Behrendt, Romina Bischoff, Imke H. E. Korf, Sarah Wienecke, Antonia Dannheim, Holger Ziehr, Christine Rohde, Achim D. Gruber, Jean-Damien Ricard, Laurent Debarbieux, Martin Witzenrath, Geraldine Nouailles   +16 more
doaj   +2 more sources

Lytic Activity of Various Phage Cocktails on Multidrug-Resistant Bacteria

Clinical and Investigative Medicine, 2016
Purpose A bacteriophage is a virus that infects and replicates within a bacterium following the injection of phage genome into the bacterial cytoplasm. They are seen as a possible therapy for multi-drug-resistant strains of many bacteria. The aim of this study is to evaluate the lytic activity of the Pyo, Intesti and Fersisi bacteriophage cocktails on ...
I, Ozkan, E, Akturk, N, Yeshenkulov, S, Atmaca, N, Rahmanov, H I, Atabay   +5 more
core   +7 more sources

Designing phage cocktails to combat the emergence of bacteriophage-resistant mutants in multidrug-resistant Klebsiella pneumoniae [PDF]

Microbiology Spectrum
Phage therapy, an emerging strategy in the fight against recalcitrant bacterial infections, encounters a significant hurdle posed by the development of phage-resistant bacterial strains. To address this concern, we suggest a novel phage cocktail.
Seongjun Yoo, Kang-Mu Lee, Nayoung Kim, Thao Nguyen Vu, Ricardo Abadie, Dongeun Yong   +5 more
doaj   +2 more sources

Rapid resistance evolution against phage cocktails. [PDF]

ISME J
When bacteria are treated with multiple antibiotics simultaneously, resistance is highly unlikely to evolve. In stark contrast, resistance against multiple phages frequently arises during therapy. Why does resistance against multi-phage cocktails evolve so easily?
van der Steen BA, Gralka M, Mulla Y.
europepmc   +3 more sources

Phage Cocktails and the Future of Phage Therapy

Future Microbiology, 2013
Viruses of bacteria, known as bacteriophages or phages, were discovered nearly 100 years ago. Their potential as antibacterial agents was appreciated almost immediately, with the first 'phage therapy' trials predating Fleming's discovery of penicillin by approximately a decade.
Stephen T Abedon, Benjamin Chan, Catherine Loc-Carrillo   +2 more
exaly   +3 more sources

Phage cocktail strategies for the suppression of a pathogen in a cross‐feeding coculture [PDF]

Microbial Biotechnology, 2020
Summary Cocktail combinations of bacteria‐infecting viruses (bacteriophages) can suppress pathogenic bacterial growth. However, predicting how phage cocktails influence microbial communities with complex ecological interactions, specifically cross ...
Lisa Fazzino, Jeremy Anisman, Jeremy M. Chacón, William R. Harcombe   +3 more
doaj   +3 more sources

Synergy as a rationale for phage therapy using phage cocktails [PDF]

PeerJ, 2014
Where phages are used to treat bacterial contaminations and infections, multiple phages are typically applied at once as a cocktail. When two or more phages in the cocktail attack the same bacterium, the combination may produce better killing than any ...
Matthew Schmerer, Ian J. Molineux, James J. Bull   +2 more
doaj   +5 more sources

Synergistic effects of halo-plaque forming phage cocktails against polymicrobial Acinetobacter baumannii and Staphylococcus aureus [PDF]

Microbiology Spectrum
Antimicrobial resistance is a growing global health crisis, with polymicrobial infections caused by Acinetobacter baumannii and Staphylococcus aureus posing a significant healthcare challenge due to their synergistic virulence, multidrug resistance, high
Ampapan Naknaen, Arrita Rueangrit, Wanna Sudhikaran, Arnon Chukamnerd, Sanicha Chumtong, Sarunyou Chusri, Rattanaruji Pomwised, Komwit Surachat, Kamonnut Singkhamanan, Ruttayaporn Ngasaman   +9 more
doaj   +2 more sources