Results 31 to 40 of about 149,596 (212)

Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage Susceptibility. [PDF]

Antibiotics (Basel), 2022
Multidrug-resistant (MDR) Enterococcus faecium is a challenging nosocomial pathogen known to colonize medical device surfaces and form biofilms.
Kunz Coyne AJ, Stamper K, Kebriaei R, Holger DJ, El Ghali A, Morrisette T, Biswas B, Wilson M, Deschenes MV, Canfield GS, Duerkop BA, Arias CA, Rybak MJ.   +12 more
europepmc   +2 more sources

Alhagi maurorum extract in combination with lytic phage cocktails: a promising therapeutic approach against biofilms of multi-drug resistant P. mirabilis. [PDF]

Front Pharmacol
Antimicrobial resistance (AMR) poses a significant global threat to public health systems, rendering antibiotics ineffective in treating infectious diseases.
Mirzaei A, Esfahani BN, Ghanadian M, Wagemans J, Lavigne R, Moghim S.   +5 more
europepmc   +2 more sources

Efficacy of precisely tailored phage cocktails targeting carbapenem-resistant Acinetobacter baumannii reveals evolutionary trade-offs: a proof-of-concept study. [PDF]

EBioMedicine
Summary Background The rapid emergence of phage-resistant bacterial mutants and the challenge of developing tailored phage cocktails have significantly hindered the broad application of phage therapy.
Liu Z, Tan X, Xiong M, Lu S, Yang Y, Zhu H, Zhang J, Luo X, Zhou C, Wei S, Zhou N, Liu X, Bai C, Pan Y, Ma Y.   +14 more
europepmc   +2 more sources

Design of Lytic Phage Cocktails Targeting Salmonella: Synergistic Effects Based on In Vitro Lysis, In Vivo Protection, and Biofilm Intervention [PDF]

Viruses
Salmonella is a major zoonotic pathogen and phage cocktails offer a novel strategy against its infections. This study aimed to characterize Salmonella phages and assess the efficacy of various phage combinations, both in vitro and in vivo.
Mengrui Zhang, Qishan Song, Zhengjie Liu, Martha R. J. Clokie, Thomas Sicheritz-Pontén, Bent Petersen, Xiaoqian Wang, Qing Zhang, Xiaohui Xu, Yanbo Luo, Pingbin Lv, Yuqing Liu, Lulu Li   +12 more
doaj   +2 more sources

<i>In vivo</i> efficacy of phage cocktails against carbapenem resistance <i>Acinetobacter baumannii</i> in the rat pneumonia model. [PDF]

J Virol
Acinetobacter baumannii, an opportunistic pathogen, poses a significant threat in intensive care units, leading to severe nosocomial infections. The rise of multi-drug-resistant strains, particularly carbapenem-resistant A.
Li S, Wei B, Xu L, Cong C, Murtaza B, Wang L, Li X, Li J, Xu M, Yin J, Xu Y.   +10 more
europepmc   +2 more sources

Synergy as a rationale for phage therapy using phage cocktails [PDF]

PeerJ, 2014
Where phages are used to treat bacterial contaminations and infections, multiple phages are typically applied at once as a cocktail. When two or more phages in the cocktail attack the same bacterium, the combination may produce better killing than any ...
Matthew Schmerer, Ian J. Molineux, James J. Bull   +2 more
doaj   +4 more sources

Optimizing the Timing and Composition of Therapeutic Phage Cocktails: A Control-Theoretic Approach. [PDF]

Bull Math Biol, 2020
Viruses that infect bacteria, i.e., bacteriophage or ‘phage,’ are increasingly considered as treatment options for the control and clearance of bacterial infections, particularly as compassionate use therapy for multi-drug-resistant infections.
Li G, Leung CY, Wardi Y, Debarbieux L, Weitz JS.   +4 more
europepmc   +2 more sources

Phage Cocktails can Prevent the Evolution of Phage-Resistant Enterococcus [PDF]

bioRxiv, 2021
Antibiotic resistant Enterococcus infections are a major health crisis that requires the development of alternative therapies. Phage therapy could be an alternative to antibiotics and has shown promise in in vitro and in early clinical studies.
Stephen Wandro, Pooja Ghatbale, Hedieh Attai, Clark Hendrickson, Cyril Samillano, Joy Suh, D. Pride, Katrine L. Whiteson   +7 more
semanticscholar   +2 more sources

A game of resistance: War between bacteria and phages and how phage cocktails can be the solution.

Virology
While phages hold promise as an antibiotic alternative, they encounter significant challenges in combating bacterial infections, primarily due to the emergence of phage-resistant bacteria.
Pedro Costa, C. Pereira, J. Romalde, Adelaide Almeida   +3 more
semanticscholar   +3 more sources

Evaluation of the Lytic Activity of Various Phage Cocktails Against, ESBL-Producer, Non-Producer and Carbapenem-Resistant Escherichia coli Isolates. [PDF]

Indian J Microbiol, 2023
Uskudar-Guclu A, Yalcin S, Unlu S, Mirza HC, Basustaoglu A.   +4 more
europepmc   +2 more sources