Results 31 to 40 of about 5,258 (146)

Antibacterial effect of phage cocktails and phage-antibiotic synergy against pathogenic <i>Klebsiella pneumoniae</i>. [PDF]

mSystems
ABSTRACT The global rise of antibiotic resistance has renewed interest in phage therapy, as an alternative to antibiotics to eliminate multidrug-resistant (MDR) bacterial pathogens. However, optimizing the broad-spectrum efficacy of phage therapy remains a challenge.
Zhao M, Li H, Gan D, Wang M, Deng H, Yang QE.   +5 more
europepmc   +4 more sources

Computational Basis for On-Demand Production of Diversified Therapeutic Phage Cocktails. [PDF]

mSystems, 2020
The antibiotic resistance crisis has led to renewed interest in phage therapy as an alternative means of treating infection. However, conventional methods for isolating pathogen-specific phage are slow, labor-intensive, and frequently unsuccessful. We have demonstrated that computationally identified prophages carried by near-neighbor bacteria can ...
Mageeney CM, Sinha A, Mosesso RA, Medlin DL, Lau BY, Rokes AB, Lane TW, Branda SS, Williams KP.   +8 more
europepmc   +6 more sources

Evaluating the effectiveness of a non-locally developed commercial phage cocktail on Kenyan Pseudomonas aeruginosa isolates

Journal of Microbiology and Infectious Diseases, 2023
Objectives: The use of bacteriophages (phages) as an alternative treatment for multidrug-resistant bacteria has recently gained popularity. Phage cocktails have been proposed for broad-spectrum therapeutic effects against such resistant bacteria ...
Ivy Jepkurui Mutai, Martin Georges, Atunga Nyachieo, Eric Odoyo, Anthony Kebira Nyamache, Jillani Ngalla   +5 more
doaj   +1 more source

Multireceptor phage cocktail against Salmonella enterica to circumvent phage resistance [PDF]

microLife
Abstract Non-Typhoidal Salmonella (NTS) is one of the most common food-borne pathogens worldwide, with poultry products being the major vehicle for pathogenesis in humans. The use of bacteriophage (phage) cocktails has recently emerged as a novel approach to enhancing food safety.
Carlos E Martinez-Soto, Michael McClelland, Andrew M Kropinski, Janet T Lin, Cezar M Khursigara, Hany Anany   +5 more
openaire   +3 more sources

Model-informed development of bacteriophage therapy: bridging in vitro and in vivo efficacy against multidrug-resistant Pseudomonas aeruginosa

mSystems
Bacteriophages are emerging as promising alternatives to antibiotics for multidrug-resistant (MDR) infections. However, their unique pharmacokinetic and pharmacodynamic (PKPD) properties arising from host-dependent amplification present challenges for ...
Jun Seok Cha, Kyungnam Kim, Hwa Jeong You, Dasom Kim, Hyun Hee Park, SuJin Heo, Choon Ok Kim, Byung Hak Jin, Dongeun Yong, Dongwoo Chae   +9 more
doaj   +1 more source

PHAGE COCKTAILS AGAINST HIGHLY MULTI-DRUG RESISTANT ACINETOBACTER BAUMANII

The Iraqi Journal of Medical Sciences, 2018
Background:Phage therapy is a potential alternative treatment for infections caused by many bacterial species such as Acinetobacter baumannii (A.
Hayder Jasim, Ahmad Abdul-Ameer
doaj   +1 more source

Isolation and characterization of φkm18p, a novel lytic phage with therapeutic potential against extensively drug resistant Acinetobacter baumannii. [PDF]

PLoS ONE, 2012
AIMS: To isolate phages against extensively drug resistant Acinetobacter baumannii (XDRAB) and characterize the highest lytic capability phage as a model to evaluate the potential on phage therapy.
Gwan-Han Shen, Jiun-Ling Wang, Fu-Shyan Wen, Kai-Ming Chang, Chih-Feng Kuo, Chun-Hung Lin, Huei-Ru Luo, Chih-Hsin Hung   +7 more
doaj   +1 more source

A Method for Generation Phage Cocktail with Great Therapeutic Potential

PLoS ONE, 2012
Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant variants after phage treatment limited its therapeutic application.In this study, an approach, named "Step-by-Step" (SBS), has been established.
Jingmin Gu, Xiaohe Liu, Yue Li, Wenyu Han, Liancheng Lei, Yongjun Yang, Honglei Zhao, Yu Gao, Jun Song, Rong Lu, Changjiang Sun, Xin Feng   +11 more
openaire   +4 more sources

A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections

Nature Communications
Bacteriophage (phage) therapy is a promising therapeutic modality for multidrug-resistant bacterial infections, but its application is mainly limited to personalized therapy due to the narrow host range of individual phages.
Minyoung Kevin Kim, Qingquan Chen, Arne Echterhof, Nina Pennetzdorfer, Robert C. McBride, Niaz Banaei, Elizabeth B. Burgener, Carlos E. Milla, Paul L. Bollyky   +8 more
doaj   +1 more source

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, EarlyView.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source