Results 21 to 30 of about 5,258 (146)
Pharmaceuticals, 2021 Phage therapy is the use of bacterial viruses as antibacterial agents. A primary consideration for commercial development of phages for phage therapy is the number of different bacterial strains that are successfully targeted, as this defines the breadth
Stephen T. Abedon +2 more
doaj +1 more source
Efficacy of precisely tailored phage cocktails targeting carbapenem-resistant Acinetobacter baumannii reveals evolutionary trade-offs: a proof-of-concept study [PDF]
EBioMedicineYingfei Ma, Changqing Bai
exaly +2 more sources
Rapid resistance evolution against phage cocktails. [PDF]
ISME JWhen bacteria are treated with multiple antibiotics simultaneously, resistance is highly unlikely to evolve. In stark contrast, resistance against multiple phages frequently arises during therapy. Why does resistance against multi-phage cocktails evolve so easily?
van der Steen BA, Gralka M, Mulla Y.
europepmc +3 more sources
A Novel Method to Create Efficient Phage Cocktails via Use of Phage-Resistant Bacteria. [PDF]
Appl Environ Microbiol, 2022 The rapid antiphage mutation of pathogens is a big challenge often encountered in phage therapy. Using a cocktail composed of phages with different infection strategies can better overcome this problem.
Li C, Shi T, Sun Y, Zhang Y.
europepmc +3 more sources
Phage cocktail powder for Pseudomonas aeruginosa respiratory infections
International Journal of Pharmaceutics, 2021 Phage cocktail broadens the host range compared with a single phage and minimizes the development of phage-resistant bacteria thereby promoting the long-term usefulness of inhaled phage therapy. In this study, we produced a phage cocktail powder by spray drying three Pseudomonas phages PEV2 (podovirus), PEV1 and PEV20 (both myovirus) with lactose (80 ...
Li, Mengyu +5 more
openaire +5 more sources
Ecotoxicology and Environmental Safety, 2022 Using bacteriophages (phages) as environmental sanitizers has been recognized as a potential alternative method to remove bacterial contamination in vitro; however, very few studies are available on the application of phages for infection control in ...
Li-Kuang Chen +12 more
doaj +1 more source
Development of a broad-host-range phage cocktail for biocontrol [PDF]
Bioengineered Bugs, 2011 The aims of this study were to investigate the incidence of different resistance mechanisms to phage K in a bank of Irish Staph aureus hospital strains; and to develop a broad host-range phage cocktail with enhanced lytic activity against those strains which were previously phage resistant.
David, Kelly +4 more
openaire +2 more sources
A phage cocktail for drug-resistant mycobacteria [PDF]
Nature Reviews Microbiology, 2019 This study reports the use of a three-phage cocktail in the treatment of disseminated drug-resistant Mycobacterium abscessus.
openaire +2 more sources
Frontiers in Microbiology, 2016 The objective of this study is to determine the in vitro susceptibility of Georgian bacteriophage cocktails on multi-drug resistant extended-spectrum β-lactamase producing Escherichia coli (ESBL-EC) isolated from patients' blood and urine cultures. 615 E.
Aycan Gundogdu +2 more
doaj +1 more source
2.PHAGE COCKTAILS AGAINST HIGHLY MULTI-DRUG RESISTANT ACINETOBACTER BAUMANII
The Iraqi Journal of Medical Sciences, 2019 Background:Phage therapy is a potential alternative treatment for infections caused by many bacterial species such as Acinetobacter baumannii (A.
Hayder N. Jasim, Ahmad S. Abdul-Ameer
doaj +6 more sources