Results 21 to 30 of about 345 (64)
In Vitro Design and Evaluation of Phage Cocktails Against Aeromonas salmonicida
Frontiers in Microbiology, 2018 As an alternative approach against multidrug-resistant bacterial infections, phages are now being increasingly investigated as effective therapeutic agents.
Ling Chen +9 more
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Phage Cocktails Constrain the Growth of Enterococcus
mSystems, 2022 Phages that infect pathogenic bacteria present a valuable resource for treating antibiotic-resistant infections. We isolated and developed a collection of 19 Enterococcus phages, including myoviruses, siphoviruses, and a podovirus, that can infect both ...
Stephen Wandro +8 more
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Phenotypic heterogeneity shapes phage resistance and cocktail efficacy in Klebsiella pneumoniae
Microbiology SpectrumThe emergence of phage-resistant bacteria poses a significant challenge to the success of phage therapy. Although phage cocktails can delay resistance, their efficacy relies on the ability to target the full spectrum of resistant variants, which are ...
Lucas Mora-Quilis +2 more
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Phage cocktail strategies for the suppression of a pathogen in a cross‐feeding coculture
Microbial Biotechnology, 2020 Summary Cocktail combinations of bacteria‐infecting viruses (bacteriophages) can suppress pathogenic bacterial growth. However, predicting how phage cocktails influence microbial communities with complex ecological interactions, specifically cross ...
Lisa Fazzino +3 more
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Anti-Biofilm Effect of Bacteriophages and Antibiotics against Uropathogenic Escherichia coli
Antibiotics, 2022 Escherichia coli is a common cause of biofilm-associated urinary tract infections. Bacteria inside the biofilm are more resistant to antibiotics. Six E.
Laima Mukane +4 more
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Directed in Vitro Evolution of Therapeutic Bacteriophages: The Appelmans Protocol
Viruses, 2019 The ‘Appelmans protocol’ is used by Eastern European researchers to generate therapeutic phages with novel lytic host ranges. Phage cocktails are iteratively grown on a suite of mostly refractory bacterial isolates until the evolved cocktail ...
Ben H. Burrowes +2 more
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Microbiology SpectrumMultidrug-resistant (MDR) Pseudomonas aeruginosa poses a significant global health threat, necessitating alternative therapeutic strategies. Bacteriophage therapy shows promise, but single-phage use is prone to resistance.
Meshack Tweya Omwega +8 more
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Synergy as a rationale for phage therapy using phage cocktails [PDF]
PeerJ, 2014 Where phages are used to treat bacterial contaminations and infections, multiple phages are typically applied at once as a cocktail. When two or more phages in the cocktail attack the same bacterium, the combination may produce better killing than any ...
Matthew Schmerer +2 more
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Phage Cocktails for Biological Decontamination: A Narrative Review of Applications, Formulation Challenges, and Translational Barriers [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Healthcare-associated infections and the increasing prevalence of antimicrobial resistance are among the most critical global public health challenges.
Golnar Rahimzadeh, Mohammad Sadegh Rezai
doaj
MethodsXSpot overlay assays are a common method for measuring phage activity against target microorganisms and determining % host range activity. Dilutions of phage demonstrate activity by creating a zone of clearing indicative of bacterial killing; however ...
Steven Arcidiacono, Robert Stote
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