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Crystal structure of the engineered endolysin mtEC340M
Acta Crystallographica Section F Structural Biology Communications, 2023Endolysins produced by bacteriophages play essential roles in the release of phage progeny by degrading the peptidoglycan layers of the bacterial cell wall. Bacteriophage-encoded endolysins have emerged as a new class of antibacterial agents to combat surging antibiotic resistance.
Jee-Min Wang +4 more
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In the last phase of their life cycle, bacteriophages form lytic enzymes known as bacteriophage endolysins that destroy the bacterial cell wall and liberate new virions. Endolysins have emerged as high-scope antimicrobial agents, especially against Gram-positive infections, due to their specificity, rapid action, and ability to target essential cell ...
Nidhi, Prajapati +5 more
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Nidhi, Prajapati +5 more
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A Computational Method for the Identification of Endolysins and Autolysins
Protein & Peptide Letters, 2020Background: Cell lytic enzyme is a kind of highly evolved protein, which can destroy the cell structure and kill the bacteria. Compared with antibiotics, cell lytic enzyme will not cause serious problem of drug resistance of pathogenic bacteria. Thus, the study of cell wall lytic enzymes aims at finding an efficient way for curing bacteria infectious.
Lei Xu +5 more
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C‐terminal anchor endolysins—proposing a third class of tailed bacteriophage endolysins
FEBS LettersEndolysins—enzymes produced by tailed bacteriophages to degrade bacterial cell walls—have traditionally been classified as canonical or signal‐anchor‐release (SAR) endolysins. However, analysis of expanding viral (meta)genomic data has revealed a third class, which we designate as C‐terminal anchor (CTA) endolysins.
Elina Cernooka +2 more
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Proteins: Structure, Function, and Bioinformatics, 2017
AbstractThe lytic enzyme, endolysin, is encoded by bacteriophages (phages) to destroy the peptidoglycan layer of host bacterial cells. The release of phage progenies to start the new infection cycle is dependent on the cell lysis event. Endolysin encoded by DLP12 cryptic prophage is a SAR endolysin which is retained by the bacterium presumably due to ...
Kesavan Babu +2 more
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AbstractThe lytic enzyme, endolysin, is encoded by bacteriophages (phages) to destroy the peptidoglycan layer of host bacterial cells. The release of phage progenies to start the new infection cycle is dependent on the cell lysis event. Endolysin encoded by DLP12 cryptic prophage is a SAR endolysin which is retained by the bacterium presumably due to ...
Kesavan Babu +2 more
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Bacteriophage endolysins: applications for food safety
Current Opinion in Biotechnology, 2016Bacteriophage endolysins (peptidoglycan hydrolases) have emerged as a new class of antimicrobial agents useful for controlling bacterial infection or other unwanted contaminations in various fields, particularly in the light of the worldwide increasing frequency of drug-resistant pathogens.
Schmelcher M, Loessner MJ
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Endopeptidase Activity of Phage λ-Endolysin
Nature New Biology, 1971JACOB and Fuerst1,2 demonstrated the presence of a bacteriolytic enzyme (λ-endolysin) in the induced cultures of lysogenic Escherichia coli K12 (λ). The enzyme was later identified as the product of gene R; of phage λ3 which is involved in bacterial lysis at the end of a latent period. The enzyme is apt to form spheroplast-like structures in E.
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