Endolysin Regulation in Phage Mu Lysis
mBio, 2022 Bacteriophage Mu is a paradigm coliphage studied mainly because of its use of transposition for genome replication. However, in extensive nonsense mutant screens, only one lysis gene has been identified, the endolysin gp22.
Jake S. Chamblee +7 more
doaj +3 more sources
Molecular aspects and comparative genomics of bacteriophage endolysins [PDF]
Journal of Virology, 2013 Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is predominantly determined by their dynamic adaptation capacities, when confronted with different selective pressures in an endless cycle of co-evolution with
Azeredo, Joana +7 more
core +6 more sources
The Iraqi Journal of Medical Sciences, 2019 Background: Persistent infection with multidrug resistant Pseudomonas aeruginosa (P. aeruginosa) represents a real problem for health care providers. Bacteriophage lytic enzymes or lysins are highly evolved molecules that have been specifically developed
Mohammed R. Ali +2 more
doaj +6 more sources
The preclinical and clinical progress of bacteriophages and their lytic enzymes : the parts are easier than the whole [PDF]
, 2019 The therapeutic potential of phages has been considered since their first identification more than a century ago. The evident concept of using a natural predator to treat bacterial infections has, however, since then been challenged considerably ...
Abdelkader, Karim Abdelkader Soufi +4 more
core +1 more source
Monitoring in real time the formation and removal of biofilms from clinical related pathogens using an impedance-based technology [PDF]
, 2017 Bacteria found in diverse ecosystems grow in a community of aggregated cells that favors their survival and colonization. Different extracellular polymeric substances are used to entrap this multispecies community forming a biofilm, which can be ...
García Suárez, María Pilar +4 more
core +1 more source
Phage lytic proteins: Biotechnological applications beyond clinical antimicrobials [PDF]
, 2017 Most bacteriophages encode two types of cell wall lytic proteins: endolysins (lysins) and virion-associated peptidoglycan hydrolases. Both enzymes have the ability to degrade the peptidoglycan of Gram-positive bacteria resulting in cell lysis when they ...
Donovan, David M. +5 more
core +1 more source
PHAGE COCKTAILS AGAINST HIGHLY MULTI-DRUG RESISTANT ACINETOBACTER BAUMANII
The Iraqi Journal of Medical Sciences, 2018 Background:Phage therapy is a potential alternative treatment for infections caused by many bacterial species such as Acinetobacter baumannii (A.
Hayder Jasim, Ahmad Abdul-Ameer
doaj +1 more source
Inhibition of Listeria monocytogenes by Phage Lytic Enzymes Displayed on Tailored Bionanoparticles
Foods, 2022 The high mortality rate associated with Listeria monocytogenes and its ability to adapt to the harsh conditions employed in food processing has ensured that this pathogen remains a serious problem in the ready-to-eat food sector.
Edel Stone +6 more
doaj +1 more source
Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms [PDF]
, 2016 Many bacteria produce extracellular and surface-associated components such as membrane vesicles (MVs), extracellular DNA and moonlighting cytosolic proteins for which the biogenesis and export pathways are not fully understood.
Ahrens, CH +19 more
core +1 more source
Structure and activity of ChiX, a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens [PDF]
, 2018 The Gram‐negative bacterium Serratia marcescens secretes a number of proteins that are involved in extracellular chitin degradation. This so‐called chitinolytic machinery includes three types of chitinase enzymes and a lytic polysaccharide monooxygenase.
Adam Lodge +48 more
core +2 more sources