Results 11 to 20 of about 5,520 (176)

Endolysin Regulation in Phage Mu Lysis

mBio, 2022
Bacteriophage Mu is a paradigm coliphage studied mainly because of its use of transposition for genome replication. However, in extensive nonsense mutant screens, only one lysis gene has been identified, the endolysin gp22.
Jake S. Chamblee, Jolene Ramsey, Yi Chen, Lori T. Maddox, Curtis Ross, Kam H. To, Jesse L. Cahill, Ry Young   +7 more
doaj   +3 more sources

Phage-Encoded Endolysins [PDF]

Antibiotics, 2021
Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from within. There is significant evidence that proves the ability of endolysins to degrade the peptidoglycan
Fatma Abdelrahman, Maheswaran Easwaran, Oluwasegun I. Daramola, Samar Ragab, Stephanie Lynch, Tolulope J. Oduselu, Fazal Mehmood Khan, Akomolafe Ayobami, Fazal Adnan, Eduard Torrents, Swapnil Sanmukh, Ayman El-Shibiny   +11 more
openaire   +4 more sources

Human Gut Phageome Analysis Uncovers Thousands of Highly Modular Endolysins. [PDF]

Microbiologyopen
Analysis of 9141 human gut metagenomes identified 15,267 phage genomes and 3794 highly modular endolysins. The recovered endolysins showed remarkable catalytic and cell wall–binding domain diversity, highlighting the gut phageome as a rich source of novel enzybiotics with therapeutic potential against multidrug‐resistant bacteria.
Niloy RK, Jewel NA, Karim D, Rolin MH, Khan T, Akter A, Mondal SI.   +6 more
europepmc   +2 more sources

Immunogenicity of Endolysin PlyC

Antibiotics, 2022
Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms. Since non-human proteins are efficient inducers of specific immune responses, including the IgG response or the development of an allergic response mediated ...
Marek Adam Harhala, Katarzyna Gembara, Daniel C. Nelson, Paulina Miernikiewicz, Krystyna Dąbrowska   +4 more
openaire   +3 more sources

Endolysins of bacteriophages

Journal of microbiology, epidemiology and immunobiology, 2023
Bacteriophage endolysins are a biologically active substances that play a specific role in the release of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of antibiotic resistance, endolysins are considered as alternative therapeutic agents because of their exceptional ability to target bacterial cells.
Irina A. Barkova, Margarita P. Izhberdeeva, Anastasiya A. Sautkina   +2 more
openaire   +2 more sources

Endolysins as Antimicrobials [PDF]

, 2012
Peptidoglycan (PG) is the major structural component of the bacterial cell wall. Bacteria have autolytic PG hydrolases that allow the cell to grow and divide. A well-studied group of PG hydrolase enzymes are the bacteriophage endolysins. Endolysins are PG-degrading proteins that allow the phage to escape from the bacterial cell during the phage lytic ...
Nelson, Daniel C., Schmelcher, Mathias, Rodríguez, Lorena, Klumpp, Jochen, Pritchard, David G., Dong, Shengli, Donovan, David M.   +6 more
openaire   +3 more sources

Crystallographic Structure Determination of Bacteriophage Endolysins [PDF]

Current Issues in Molecular Biology, 2020
Bacteriophages produce endolysins that target and cleave the hosts peptidoglycan to release their progeny at the end of the infection cycle. These proteins can be used for the eradication of pathogenic bacteria, but also for their detection. Endolysins may contain a single catalytic domain or several domains, including a cell wall binding domain.
Sanz-Gaitero, Marta, van Raaij, Mark J.
openaire   +3 more sources

Development of sensitizer peptide-fused endolysin Lys1S-L9P acting against multidrug-resistant gram-negative bacteria

Frontiers in Microbiology, 2023
The advent of multidrug-resistant (MDR) bacteria poses a major threat to public health, garnering attention to novel antibiotic replacements. Endolysin, a bacteriophage-derived cell wall-degrading enzyme, is a promising alternative to conventional ...
Su Min Son, Su Min Son, Su Min Son, Joonbeom Kim, Joonbeom Kim, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu   +7 more
doaj   +1 more source

Characterization of Salmonella endolysin XFII produced by recombinant Escherichia coli and its application combined with chitosan in lysing Gram-negative bacteria

Microbial Cell Factories, 2022
Background   Salmonella is a common foodborne pathogen, which can cause intestinal diseases. In the last decades, the overuse of antibiotics has led to a pandemic of drug-resistant bacterial infections.
Shuhang Zhang, Yan Chang, Qing Zhang, Yingbo Yuan, Qingsheng Qi, Xuemei Lu   +5 more
doaj   +1 more source

Recent Advances in Endolysin Engineering. [PDF]

Antibiotics (Basel)
Antimicrobial resistance threatens a new “dark age” in medical practice. Chronic antibiotic overuse has driven the rise in antimicrobial resistance and promoted the emergence of multidrug-resistant organisms. To address this problem, researchers have developed new approaches.
Aitken M, Abeysekera G, Billington C, Dobson RCJ.   +3 more
europepmc   +4 more sources