Results 11 to 20 of about 89 (88)
Phage-Encoded Endolysins [PDF]
Antibiotics, 2021 Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from within. There is significant evidence that proves the ability of endolysins to degrade the peptidoglycan
Fatma Abdelrahman +11 more
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Immunogenicity of Endolysin PlyC
Antibiotics, 2022 Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms. Since non-human proteins are efficient inducers of specific immune responses, including the IgG response or the development of an allergic response mediated ...
Marek Adam Harhala +4 more
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Bacteriophage Endolysins as Novel Antimicrobials [PDF]
Future Microbiology, 2012 Endolysins are enzymes used by bacteriophages at the end of their replication cycle to degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release of progeny virions. Due to the absence of an outer membrane in the Gram-positive bacterial cell wall, endolysins can access the peptidoglycan and destroy these organisms ...
Mathias, Schmelcher +2 more
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Journal of microbiology, epidemiology and immunobiology, 2023 Bacteriophage endolysins are a biologically active substances that play a specific role in the release of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of antibiotic resistance, endolysins are considered as alternative therapeutic agents because of their exceptional ability to target bacterial cells.
Irina A. Barkova +2 more
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Crystallographic Structure Determination of Bacteriophage Endolysins [PDF]
Current Issues in Molecular Biology, 2020 Bacteriophages produce endolysins that target and cleave the hosts peptidoglycan to release their progeny at the end of the infection cycle. These proteins can be used for the eradication of pathogenic bacteria, but also for their detection. Endolysins may contain a single catalytic domain or several domains, including a cell wall binding domain.
Sanz-Gaitero, Marta, van Raaij, Mark J.
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Synthetic biology of modular endolysins [PDF]
Biotechnology Advances, 2018 Endolysins and their derivatives have emerged in recent years as a novel class of antibacterials, which have now entered the clinical phases. Their rapid mode-of-action and proteinaceous nature differentiates them from any other class of antibiotics. A key feature of endolysins is their modularity and the opportunities that emerge thereof to customize ...
Gerstmans, Hans +2 more
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Endolysins as Antimicrobials [PDF]
, 2012 Peptidoglycan (PG) is the major structural component of the bacterial cell wall. Bacteria have autolytic PG hydrolases that allow the cell to grow and divide. A well-studied group of PG hydrolase enzymes are the bacteriophage endolysins. Endolysins are PG-degrading proteins that allow the phage to escape from the bacterial cell during the phage lytic ...
Nelson, Daniel C. +6 more
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Endolysins against Streptococci as an antibiotic alternative
Frontiers in Microbiology, 2022 Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis.
Kuan Yee Wong +6 more
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The Advantages and Challenges of Using Endolysins in a Clinical Setting [PDF]
Viruses, 2021 Antibiotic-resistant pathogens are increasingly more prevalent and problematic. Traditional antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes and so new approaches are needed. Bacteriophage-derived proteins such as endolysins could offer one effective solution.
Ellen Murray +3 more
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Bacteriophage Endolysins and their Applications
Science Progress, 2016 Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degrade specific bonds within the bacterial cell wall. These enzymes represent a novel class of antibacterial agents against infectious pathogens, especially in light of multidrug-resistant bacteria, which have made antibiotic therapy increasingly redundant.
Jude, Ajuebor +5 more
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