Results 31 to 40 of about 5,520 (176)

Antibacterial activity of vB_AbaM_PhT2 phage hydrophobic amino acid fusion endolysin, combined with colistin against Acinetobacter baumannii

Scientific Reports, 2023
Phage lytic enzymes are promising antimicrobial agents. In this study, an endolysin derived from vB_AbaM_PhT2 (vPhT2), was identified. This endolysin represented the conserved lysozyme domain.
Sutthirat Sitthisak, Suphattra Manrueang, Supat Khongfak, Udomluk Leungtongkam, Rapee Thummeepak, Aunchalee Thanwisai, Nathan Burton, Gurneet K. Dhanoa, Panagiotis Tsapras, Antonia P. Sagona   +9 more
doaj   +1 more source

Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection

BMC Microbiology, 2011
Background Interest in phage therapy has grown over the past decade due to the rapid emergence of antibiotic resistance in bacterial pathogens. However, the use of bacteriophages for therapeutic purposes has raised concerns over the potential for immune ...
Kempashanaiah Nanjundappa, Hariharan Sukumar, Rajagopalan Sanjeev, Sundarrajan Sudarson, Paul Vivek, Padmanabhan Sriram, Sriram Bharathi, Ramachandran Janakiraman   +7 more
doaj   +1 more source

Development of a Novel Chimeric Endolysin, Lys109 With Enhanced Lytic Activity Against Staphylococcus aureus

Frontiers in Microbiology, 2021
As the incidence of antibiotic-resistant bacteria has become increased, phage endolysins are believed as one of the promising alternatives to antibiotics.
Bokyung Son, Bokyung Son, Minsuk Kong, Yoona Lee, Yoona Lee, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu   +7 more
doaj   +1 more source

The Holin-Endolysin Lysis System of the OP2-Like Phage X2 Infecting Xanthomonas oryzae pv. oryzae

Viruses, 2021
Most endolysins of dsDNA phages are exported by a holin-dependent mechanism, while in some cases endolysins are exported via a holin-independent mechanism.
Zhifeng Wu, Yang Zhang, Xinyang Xu, Temoor Ahmed, Yong Yang, Belinda Loh, Sebastian Leptihn, Chenqi Yan, Jianping Chen, Bin Li   +9 more
doaj   +1 more source

Two Distinct Modes of Lysis Regulation in Campylobacter Fletchervirus and Firehammervirus Phages

Viruses, 2020
Campylobacter phages are divided into two genera; Fletchervirus and Firehammervirus, showing only limited intergenus homology. Here, we aim to identify the lytic genes of both genera using two representative phages (F352 and F379) from our collection. We
Athina Zampara, Stephen J. Ahern, Yves Briers, Lone Brøndsted, Martine Camilla Holst Sørensen   +4 more
doaj   +1 more source

Formation of therapeutic phage cocktail and endolysin to highly multi-drug resistant Acinetobacter baumannii: in vitro and in vivo study [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Phage therapy is a potential alternative treatment for infections caused by Acinetobacter baumannii, a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and ...
Hayder Nsaif Jasim, Rand Riadh Hafidh, Ahmed Sahib Abdulamir   +2 more
doaj   +1 more source

A Thermophilic Phage Endolysin Fusion to a Clostridium perfringens-Specific Cell Wall Binding Domain Creates an Anti-Clostridium Antimicrobial with Improved Thermostability

Viruses, 2015
Clostridium perfringens is the third leading cause of human foodborne bacterial disease and is the presumptive etiologic agent of necrotic enteritis among chickens. Treatment of poultry with antibiotics is becoming less acceptable.
Steven M. Swift, Bruce S. Seal, Johnna K. Garrish, Brian B. Oakley, Kelli Hiett, Hung-Yueh Yeh, Rebekah Woolsey, Kathleen M. Schegg, John Eric Line, David M. Donovan   +9 more
doaj   +1 more source

Engineering strategies and challenges of endolysin as an antibacterial agent against Gram‐negative bacteria

Microbial Biotechnology
Bacteriophage endolysin is a novel antibacterial agent that has attracted much attention in the prevention and control of drug‐resistant bacteria due to its unique mechanism of hydrolysing peptidoglycans.
Tianyu Zheng, Can Zhang
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

2.PHAGE COCKTAILS AGAINST HIGHLY MULTI-DRUG RESISTANT ACINETOBACTER BAUMANII

The Iraqi Journal of Medical Sciences, 2019
Background:Phage therapy is a potential alternative treatment for infections caused by many bacterial species such as Acinetobacter baumannii (A.
Hayder N. Jasim, Ahmad S. Abdul-Ameer
doaj   +6 more sources