Results 51 to 60 of about 8,598 (217)

The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor.

PLoS Pathogens, 2014
The bacteriophage ΦCD27 is capable of lysing Clostridium difficile, a pathogenic bacterium that is a major cause for nosocomial infection. A recombinant CD27L endolysin lyses C. difficile in vitro, and represents a promising alternative as a bactericide.
Matthew Dunne, Haydyn D T Mertens, Vasiliki Garefalaki, Cy M Jeffries, Andrew Thompson, Edward A Lemke, Dmitri I Svergun, Melinda J Mayer, Arjan Narbad, Rob Meijers   +9 more
doaj   +1 more source

Development of a Novel Chimeric Endolysin, Lys109 With Enhanced Lytic Activity Against Staphylococcus aureus

Frontiers in Microbiology, 2021
As the incidence of antibiotic-resistant bacteria has become increased, phage endolysins are believed as one of the promising alternatives to antibiotics.
Bokyung Son, Bokyung Son, Minsuk Kong, Yoona Lee, Yoona Lee, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu   +7 more
doaj   +1 more source

Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii [PDF]

, 2020
The multi-drug resistance of the opportunistic pathogen Acinetobacter baumannii is of growing concern, with many clinical isolates proving to be resistant to last resort as well as front line antibiotic treatments.
Christie, Gabrielle S., Dowson, Christopher G., Leungtongkam, Udomluk, Millard, Andrew D., Moat, John, Sagona, Antonia P., Sitthisak, Sutthirat, Smith, Sophie, Styles, Kathryn, Thummeepak, Rapee, Wellington, Elizabeth M. H.   +10 more
core   +1 more source

Bacteriophage Endolysins and their Applications

Science Progress, 2016
Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degrade specific bonds within the bacterial cell wall. These enzymes represent a novel class of antibacterial agents against infectious pathogens, especially in light of multidrug-resistant bacteria, which have made antibiotic therapy increasingly redundant.
Jude, Ajuebor, Olivia, McAuliffe, Jim, O'Mahony, R Paul, Ross, Colin, Hill, Aidan, Coffey   +5 more
openaire   +2 more sources

Comparative Genomics of 9 Novel Paenibacillus Larvae Bacteriophages [PDF]

, 2016
American Foulbrood Disease, caused by the bacterium Paenibacillus larvae, is one of the most destructive diseases of the honeybee, Apis mellifera. Our group recently published the sequences of 9 new phages with the ability to infect and lyse P.
Amy, Penny S., LeBlanc, Lucy, Stamereilers, Casey, Tsourkas, Philippos K., Yost, Diane   +4 more
core   +2 more sources

Therapeutic Potential of an Endolysin Derived from Kayvirus S25-3 for Staphylococcal Impetigo

Viruses, 2019
Impetigo is a contagious skin infection predominantly caused by Staphylococcus aureus. Decontamination of S. aureus from the skin is becoming more difficult because of the emergence of antibiotic-resistant strains.
Ichiro Imanishi, Jumpei Uchiyama, Toshihiro Tsukui, Junzo Hisatsune, Kaori Ide, Shigenobu Matsuzaki, Motoyuki Sugai, Koji Nishifuji   +7 more
doaj   +1 more source

Antibacterial activity of vB_AbaM_PhT2 phage hydrophobic amino acid fusion endolysin, combined with colistin against Acinetobacter baumannii

Scientific Reports, 2023
Phage lytic enzymes are promising antimicrobial agents. In this study, an endolysin derived from vB_AbaM_PhT2 (vPhT2), was identified. This endolysin represented the conserved lysozyme domain.
Sutthirat Sitthisak, Suphattra Manrueang, Supat Khongfak, Udomluk Leungtongkam, Rapee Thummeepak, Aunchalee Thanwisai, Nathan Burton, Gurneet K. Dhanoa, Panagiotis Tsapras, Antonia P. Sagona   +9 more
doaj   +1 more source

Engineered endolysin-based "artilysins" to combat multidrug-resistant gram-negative pathogens [PDF]

, 2014
The global threat to public health posed by emerging multidrug-resistant bacteria in the past few years necessitates the development of novel approaches to combat bacterial infections.
Brenner, Briers, Briers, Briers, Briers, Briers, Cenens, Church, De Corte, Delcour, Düring, Gasson, Haun, Holloway, Ibrahim, Ibrahim, Ibrahim, Ibrahim, Kümmerer, Lavigne, Loeffler, Lukacik, Masschalck, Morita, Moy, Nelson, Nelson, Nikaido, Park, Pastagia, Pirnay, Pirnay, Raetz, Schmelcher, Schuch, Stiernagle, Tan, Vaara, Walmagh, Walmagh, Yan   +40 more
core   +4 more sources

DUF3380 domain from a Salmonella phage endolysin shows potent N -acetylmuramidase activity [PDF]

, 2016
Bacteriophage-encoded endolysins are highly diverse enzymes that cleave the bacterial peptidoglycan layer. Current research focuses on their potential applications in medicine, in food conservation, and as biotechnological tools.
Hans Gerstmans, Lorena Rodríguez-Rubio, M. J. Pettinari, Rob Lavigne, Simon Thorpe, Stéphane Mesnage, Yves Briers   +6 more
core   +1 more source

Two Distinct Modes of Lysis Regulation in Campylobacter Fletchervirus and Firehammervirus Phages

Viruses, 2020
Campylobacter phages are divided into two genera; Fletchervirus and Firehammervirus, showing only limited intergenus homology. Here, we aim to identify the lytic genes of both genera using two representative phages (F352 and F379) from our collection. We
Athina Zampara, Stephen J. Ahern, Yves Briers, Lone Brøndsted, Martine Camilla Holst Sørensen   +4 more
doaj   +1 more source