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On the catalytic mechanism of bacteriophage endolysins: Opportunities for engineering

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020
Bacteriophage endolysins have the potential to be a long-term antibacterial replacement for antibiotics. The exogenous application of endolysins on some bacteria results in rapid cell lysis. The prospects for endolysins are furthered by the ability to engineer them; novel endolysins can be developed with optimised stability, specificity, and lytic ...
Michael J, Love   +4 more
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Endopeptidase Activity of Phage λ-Endolysin

Nature New Biology, 1971
JACOB and Fuerst1,2 demonstrated the presence of a bacteriolytic enzyme (λ-endolysin) in the induced cultures of lysogenic Escherichia coli K12 (λ). The enzyme was later identified as the product of gene R; of phage λ3 which is involved in bacterial lysis at the end of a latent period. The enzyme is apt to form spheroplast-like structures in E.
openaire   +2 more sources

Endolysins: Redefining Antibacterial Therapy

Future Microbiology, 2015
Bjorn Lars Herpers speaks to Natasha Leeson, Commissioning Editor: Bjorn Lars Herpers was born on 16 February 1974 in Schaesberg. In 1992 he graduated summa cum laude at Gymnasium Rolduc in Kerkrade (The Netherlands) and started to study medical biology at the University of Utrecht. After 3 years, he started to study medicine as well.
openaire   +1 more source

Bacteriophage endolysins — current state of research and applications

Current Opinion in Microbiology, 2005
Endolysins are phage-encoded enzymes that break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. Their action is tightly regulated by holins, by membrane arrest, and by conversion from their inactive to active state. Recent research has not only revealed the unexpected diversity of these highly specific hydrolases but
openaire   +2 more sources

Characterization of staphylococcal endolysin LysSAP33 possessing untypical domain composition

Journal of Microbiology, 2021
Jun-Hyeok Yu   +2 more
exaly  

An endolysin Salmcide-p1 from bacteriophage fmb-p1 against gram-negative bacteria

Journal of Applied Microbiology, 2022
Ting Nie, Fanqiang Meng, Fengxia Lu
exaly  

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