Results 61 to 70 of about 6,966 (163)

Lack of improvement after short‐term topical antistaphylococcal endolysin SA.100 therapy in patients with mild‐to‐moderate atopic dermatitis: Results from a randomized, vehicle‐controlled trial

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2409-2413, July 2026.
Abstract Atopic dermatitis (AD) is a chronic immune‐mediated inflammatory skin disease. An overgrowth of Staphylococcus aureus (S. aureus) and decreased microbial diversity is apparent in 70%–90% of AD patients. SA.100 is a recombinant endolysin targeting S. aureus that might be a novel treatment for patients with mild‐to‐moderate AD.
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Ismahaan Abdisalaam, Rianne Rijneveld, Erica S. Klaassen, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Benthe Freyee, Karin Platenkamp, Mariette E. van Poelgeest, Robert Rissmann, Martijn B. A. van Doorn, Tessa Niemeyer – van der Kolk   +15 more
wiley   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

EXTRACTION, PURIFICATION AND THERAPEUTIC USE OF BACTERIOPHAGE ENDOLYSIN AGAINST MULTI-DRUG RESISTANT PSEUDOMONAS AERUGINOSA: AN IN-VITRO AND IN-VIVO STUDY

The Iraqi Journal of Medical Sciences, 2018
Background: Persistent infection with multidrug resistant Pseudomonas aeruginosa (P. aeruginosa) represents a real problem for health care providers.
Mohammed Ali, Shurooq Kadhim, Ahmed Abdulamir   +2 more
doaj   +1 more source

Identification and Genomic Analysis of the First Salmonella typhimurium Monophasic Variant 1,4,[5],12:i:‐ Isolate Harbouring a Chromosomally Integrated blaNDM‐5

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
This study reports the first clinical isolate of the monophasic variant of Salmonella typhimurium (serotype 1,4,[5],12:i:‐) ST34 harbouring a chromosomally integrated blaNDM‐5. The ~11 kb resistance region is flanked by two directly oriented IS26 elements, forming an IS26‐composite transposon.
Shihan Zeng, Weilong Guo, Chengfeng Lin, Lianghui Peng, Jingjie Song   +4 more
wiley   +1 more source

Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma

Allergy, Volume 81, Issue 7, Page 2435-2449, July 2026.
Staphylococcus aureus, commonly colonising CTCL patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T‐cell release of barrier‐repressing cytokines (IL‐4, IL‐13, IL‐22, OSM). Cytokine signalling drives JAK‐dependent downregulation of filaggrin and loricrin in keratinocytes. Antibiotic‐mediated eradication of S. aureus induces
Maria Gluud, Emil M. Pallesen, Ziao Zeng, Martin R. J. Namini, Chella Krishna Vadivel, Lise Mette Rahbek Gjerdrum, Lang Yan, Sana Ahmad, Lise M. Lindahl, Michael Bzorek, Maria R. Kamstrup, Saptaswa Dey, Sisse Rye Ostrowski, Erik Sørensen, Pia Rantakari, Charlotte Menne Bonefeld, Carsten Geisler, Anders Woetmann, Riitta Lahesmaa, Lars Iversen, Peter Wolf, Thomas Litman, Terkild B. Buus, Niels Ødum   +23 more
wiley   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

The lysis cassette of bacteriophage φKMV encodes a signal-arrest-release endolysin and a pinholin

, 2011
The lysis cassette of Pseudomonas aeruginosa phage ϕKMV encodes a holin, endolysin, Rz and Rz1 in the canonical order. It has a tight organization with a high degree of overlapping genes and is highly conserved (between 96 and 100% identity at the ...
Yves Briers, Briers, Yves, Guido Volckaert, Peeters, Liesbet, Peeters, Liesbet M, Lavigne, Rob, Rob Lavigne, Liesbet M. Peeters, Volckaert, Guido   +8 more
core   +1 more source

Image_1_Successful use of a phage endolysin for treatment of chronic pelvic pain syndrome/chronic bacterial prostatitis.JPEG

, 2023
Chronic prostatitis (CP) is a common inflammatory condition of the prostate that is estimated to effect 2%–10% of the world’s male population. It can manifest as perineal, suprapubic, or lower back pain and urinary symptoms occurring with either ...
Malgorzata Rydzanicz (3611987), Peter Sabaka (16830192), Rafał Płoski (85995), Stanislav Šutovský (16830195), Hongming Zhang (633911), Roy H. Stevens (16830186), Michal Kajsik (16830189)   +6 more
core   +1 more source

Structure prediction of endolysin SU57e

Endolysins are used by bacteriophages to break down the cell wall of the bacterial host towards the end of the infection cycle. Endolysins are interesting options for the creation of antibacterial substances and domains from endolysins can be combined ...
Seijsing, Fredrik, Nilsson, Anders, Seijsing, Johan   +2 more
core   +2 more sources

Yeast Surface Display System for Facilitated Production and Application of Phage Endolysin

, 2020
Bacteriophage endolysin is one of the potential alternatives of conventional antibiotics, but the intrinsic limitations of the bacterial expression system may undermine the comprehensive application of this therapeutic protein.
Jaewoo Bai (6375518), Sangryeol Ryu, Sangryeol Ryu (12777), Jaewoo Bai, Jihwan Chun, Jihwan Chun (8556588)   +5 more
core   +1 more source