Results 41 to 50 of about 89 (88)
Bacterial Extracellular Vesicles in Biomedical Research and Clinical Translation
Microbial Biotechnology, Volume 19, Issue 4, April 2026.Bacterial membrane vesicle biomedical applications. ABSTRACT Bacterial Extracellular Vesicles (bEVs) are lipid (single‐ or double‐bilayer) nanostructures secreted by virtually all bacteria that play fundamental roles in intercellular communication and have emerged as powerful, multifunctional tools in biomedicine. Their intrinsic ability to encapsulate
Alejandro Arce‐Rodríguez +2 more
wiley +1 more source
Defense Systems and Prophage Detection in Streptococcus mutans Strains
Molecular Oral Microbiology, Volume 41, Issue 2, Page 57-68, April 2026.ABSTRACT Although the species is extensively studied, limited data are available on antiphage defense systems (APDSs) in Streptococcus mutans. The present study aimed to explore the diversity and the occurrence of APDSs and to search for prophages in the genomes of clinical isolates of S. mutans using bioinformatics tools.
Olivier Claisse +3 more
wiley +1 more source
Bacteriophage Therapy: Current Strategies and Future Perspectives
MedComm, Volume 7, Issue 3, March 2026.This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou +7 more
wiley +1 more source
The Emerging Role of Microbial Extracellular Vesicles in Neuroinflammation and Neurodegeneration
Medicine Bulletin, Volume 2, Issue 2, Page 231-238, March 2026.ABSTRACT Neurodegenerative and neuropsychiatric disorders are increasingly viewed as systemic conditions shaped by interactions among peripheral immunity, microbiota, and the central nervous system. However, the mechanisms linking microbial activity to neuroinflammation and neurodegeneration remain poorly defined.
Julio Jesús Estrada‐Valbuena +3 more
wiley +1 more source
Dysbiosis in the Pathogenesis of Atopic Dermatitis
The Journal of Dermatology, Volume 53, Issue 3, Page 388-398, March 2026.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Hiroki Okamoto, Yuumi Nakamura
wiley +1 more source
, 2018 The present invention relates to a polypeptide with endolysin activity and amino acid sequences according to SEQ ID No. 1 and fragments or derivatives thereof. Moreover, the present invention relates to nucleic acid molecules encoding said polypeptide, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid ...
Oliveira, Hugo Alexandre Mendes +1 more
openaire +1 more source
The impact of metagenomic analysis on the discovery of novel endolysins
Applied Microbiology and BiotechnologyAbstract Metagenomics has revolutionized enzyme discovery by enabling the study of genetic material directly from environmental samples, bypassing the need for microbial cultivation. This approach is particularly effective for identifying novel endolysins, phage-derived enzymes with antibacterial properties ...
Nikolaos Georgakis +5 more
openaire +2 more sources
Fermentation Practices Select for Thermostable Endolysins in Phages
Molecular Biology and EvolutionAbstract Endolysins are produced by (bacterio)phages and play a crucial role in degrading the bacterial cell wall and the subsequent release of new phage progeny. These lytic enzymes exhibit a remarkable diversity, often occurring in a multimodular form that combines different catalytic and cell wall-binding domains, even in phages ...
Frank Oechslin +5 more
openaire +2 more sources
Characterization of Clostridium perfringens Phage Endolysin PlyDolk21
AntibioticsBackground: Clostridium perfringens is a significant cause of food poisoning. Broad-spectrum antibiotics, commonly used to control C. perfringens, are becoming less effective due to the rise of antibiotic-resistant strains, necessitating alternative control strategies. Methods: A C.
Suyoung Seo, Bokyung Son, Minsuk Kong
openaire +3 more sources