Results 21 to 30 of about 89 (88)

Endolysin Regulation in Phage Mu Lysis

mBio, 2022
Host cell lysis is the terminal event of the bacteriophage infection cycle. In Gram-negative hosts, lysis requires proteins that disrupt each of the three cell envelope components, only one of which has been identified in Mu: the endolysin gp22.
Jake S. Chamblee, Jolene Ramsey, Yi Chen, Lori T. Maddox, Curtis Ross, Kam H. To, Jesse L. Cahill, Ry Young   +7 more
openaire   +3 more sources

Regulation of a Phage Endolysin by Disulfide Caging [PDF]

Journal of Bacteriology, 2010
ABSTRACT In contrast to canonical phage endolysins, which require holin-mediated disruption of the membrane to gain access to attack the cell wall, signal anchor release (SAR) endolysins are secreted by the host sec system, where they accumulate in an inactive form tethered to the membrane by their N ...
Gabriel F, Kuty, Min, Xu, Douglas K, Struck, Elizabeth J, Summer, Ry, Young   +4 more
openaire   +2 more sources

Endolysin, a Promising Solution against Antimicrobial Resistance [PDF]

Antibiotics, 2021
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the effective prevention and control of ever-increasing infectious diseases. The advent of pandrug-resistant bacteria makes most, if not all, available antibiotics invalid.
Mujeeb ur Rahman, Weixiao Wang, Qingqing Sun, Junaid Ali Shah, Chao Li, Yanmei Sun, Yuanrui Li, Bailing Zhang, Wei Chen, Shiwei Wang   +9 more
openaire   +3 more sources

Combination Effect of Engineered Endolysin EC340 With Antibiotics [PDF]

Frontiers in Microbiology, 2022
Bacteriophage lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages during the final stage of the lytic cycle to enable cleavage through the host’s cell wall, thus allowing the phages to burst out of their host bacteria after multiplication inside them. When applied externally to Gram-negative bacteria
Hye-Won Hong, Hye-Won Hong, Young Deuk Kim, Jaeyeon Jang, Min Soo Kim, Miryoung Song, Heejoon Myung, Heejoon Myung, Heejoon Myung   +8 more
openaire   +3 more sources

Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins [PDF]

Journal of Virology, 2013
ABSTRACT Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is determined predominantly by their dynamic adaptation capacities when confronted with different selective pressures in an endless cycle of coevolution with a widespread group of bacterial hosts.
Oliveira, Hugo, Melo, Luis D R, Santos, Silvio B, Luzia De Nobrega, Franklin, Ferreira, Eugénio C, Cerca, Nuno, Azeredo, Joana, Kluskens, Leon   +7 more
openaire   +4 more sources

Bioinformatic Analysis of Prophage Endolysins and Endolysin-Like Genes from the Order Lactobacillales

Nova Biotechnologica et Chimica, 2012
Bioinformatic Analysis of Prophage Endolysins and Endolysin-Like Genes from the Order Lactobacillales Endolysins belonging to the group of peptigoglycan hydrolases, which are able to cleave peptidoglycan in bacterial cell walls, become an extensively studied group of enzymes.
Lenka Maliničová, Peter Pristaš, Peter Javorský   +2 more
openaire   +1 more source

Bacteriophage endolysins — extending their application to tissues and the bloodstream

Current Opinion in Biotechnology, 2021
Current Opinion in Biotechnology ...
Mathias, Schmelcher, Martin J, Loessner
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Expression and delivery of an endolysin to combat Clostridium perfringens [PDF]

Applied Microbiology and Biotechnology, 2013
Clostridium perfringens is a cause for increasing concern due to its responsibility for severe infections both in humans and animals, especially poultry. To find new control strategies to treat C. perfringens infection, we investigated the activity and delivery of a bacteriophage endolysin.
GERVASI, TERESA, Horn, N., Wegmann, U., DUGO, Giacomo, Narbad, A., Mayer, M. J.   +5 more
openaire   +2 more sources

Characterization of MSlys, the endolysin of Streptococcus pneumoniae phage MS1 [PDF]

Biotechnology Reports, 2020
Despite the use of pneumococcal conjugate vaccines, the number of infections related to Streptococcus pneumoniae continues to be alarming. Herein, we identified, characterized the MSlys endolysin encoded in the phage MS1. We further tested its antimicrobial efficacy against planktonic and biofilm cells, assessing the culturability of cells and biofilm ...
Maria Daniela Silva, Hugo Oliveira, Alberta Faustino, Sanna Sillankorva   +3 more
openaire   +4 more sources

Phage Endolysins: Advances in the World of Food Safety

Cells, 2023
As antimicrobial resistance continues to escalate, the exploration of alternative approaches to safeguard food safety becomes more crucial than ever. Phage endolysins are enzymes derived from phages that possess the ability to break down bacterial cell walls.
Amina Nazir, Xiaohui Xu, Yuqing Liu, Yibao Chen   +3 more
openaire   +3 more sources