Results 21 to 30 of about 6,966 (163)

Endolysins of bacteriophage vB_Sal-S-S10 can naturally lyse Salmonella enteritidis

BMC Veterinary Research, 2022
Background The holin-endolysin lysis system plays an essential role in the phage life cycle. Endolysins are promising alternatives to antibiotics, and have been successfully used against Gram-positive bacteria.
Xinrui Wang, Lili Han, Jiaqing Rong, Huiying Ren, Wenhua Liu, Can Zhang   +5 more
doaj   +1 more source

The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor.

PLoS Pathogens, 2014
The bacteriophage ΦCD27 is capable of lysing Clostridium difficile, a pathogenic bacterium that is a major cause for nosocomial infection. A recombinant CD27L endolysin lyses C. difficile in vitro, and represents a promising alternative as a bactericide.
Matthew Dunne, Haydyn D T Mertens, Vasiliki Garefalaki, Cy M Jeffries, Andrew Thompson, Edward A Lemke, Dmitri I Svergun, Melinda J Mayer, Arjan Narbad, Rob Meijers   +9 more
doaj   +1 more source

Development of a Novel Chimeric Endolysin, Lys109 With Enhanced Lytic Activity Against Staphylococcus aureus

Frontiers in Microbiology, 2021
As the incidence of antibiotic-resistant bacteria has become increased, phage endolysins are believed as one of the promising alternatives to antibiotics.
Bokyung Son, Bokyung Son, Minsuk Kong, Yoona Lee, Yoona Lee, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu   +7 more
doaj   +1 more source

Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection

BMC Microbiology, 2011
Background Interest in phage therapy has grown over the past decade due to the rapid emergence of antibiotic resistance in bacterial pathogens. However, the use of bacteriophages for therapeutic purposes has raised concerns over the potential for immune ...
Kempashanaiah Nanjundappa, Hariharan Sukumar, Rajagopalan Sanjeev, Sundarrajan Sudarson, Paul Vivek, Padmanabhan Sriram, Sriram Bharathi, Ramachandran Janakiraman   +7 more
doaj   +1 more source

Regulation of a Phage Endolysin by Disulfide Caging [PDF]

, 2010
In contrast to canonical phage endolysins, which require holin-mediated disruption of the membrane to gain access to attack the cell wall, signal anchor release (SAR) endolysins are secreted by the host sec system, where they accumulate in an inactive ...
Gabriel F. Kuty, Min Xu, Xu, Min, Ry Young, Summer, Elizabeth, Young, Ry, Struck, Douglas, Douglas K. Struck, Kuty, Gabriel, Elizabeth J. Summer   +9 more
core   +1 more source

Two Distinct Modes of Lysis Regulation in Campylobacter Fletchervirus and Firehammervirus Phages

Viruses, 2020
Campylobacter phages are divided into two genera; Fletchervirus and Firehammervirus, showing only limited intergenus homology. Here, we aim to identify the lytic genes of both genera using two representative phages (F352 and F379) from our collection. We
Athina Zampara, Stephen J. Ahern, Yves Briers, Lone Brøndsted, Martine Camilla Holst Sørensen   +4 more
doaj   +1 more source

The Holin-Endolysin Lysis System of the OP2-Like Phage X2 Infecting Xanthomonas oryzae pv. oryzae

Viruses, 2021
Most endolysins of dsDNA phages are exported by a holin-dependent mechanism, while in some cases endolysins are exported via a holin-independent mechanism.
Zhifeng Wu, Yang Zhang, Xinyang Xu, Temoor Ahmed, Yong Yang, Belinda Loh, Sebastian Leptihn, Chenqi Yan, Jianping Chen, Bin Li   +9 more
doaj   +1 more source

Identification of endolysin.

, 2013
A. Amino acid sequence of IME-EF1 endolysin was aligned and phylogenized with the submitted, confirmed, or putative endolysin from six strains of E. faecalis bacteriophage in GenBank. B.
Hang Fan (483932), Yigang Tong (36054), Zhiqiang Mi (483931), Xiaoping An (36048), Zhiyi Zhang (279187), Xiuyun Yin (27345), Wenhui Zhang (425538), Jiankui Chen (483933)   +7 more
core   +1 more source

Formation of therapeutic phage cocktail and endolysin to highly multi-drug resistant Acinetobacter baumannii: in vitro and in vivo study [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Phage therapy is a potential alternative treatment for infections caused by Acinetobacter baumannii, a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and ...
Hayder Nsaif Jasim, Rand Riadh Hafidh, Ahmed Sahib Abdulamir   +2 more
doaj   +1 more source

Endolysin CRISPR hit distribution.

, 2016
Endolysin CRISPR hit distribution.
Devaki Bhaya (268447), Michelle Davison (3112482), Todd J. Treangen (160233), Sergey Koren (553953), Mihai Pop (48593)   +4 more
core   +1 more source