Results 21 to 30 of about 5,520 (176)
Synthetic biology of modular endolysins [PDF]
Biotechnology Advances, 2018 Endolysins and their derivatives have emerged in recent years as a novel class of antibacterials, which have now entered the clinical phases. Their rapid mode-of-action and proteinaceous nature differentiates them from any other class of antibiotics. A key feature of endolysins is their modularity and the opportunities that emerge thereof to customize ...
Gerstmans, Hans +2 more
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Complete Genomic and Lysis-Cassette Characterization of the Novel Phage, KBNP1315, which Infects Avian Pathogenic Escherichia coli (APEC). [PDF]
PLoS ONE, 2015 Avian pathogenic Escherichia coli (APEC) is a major pathogen that causes avian colibacillosis and is associated with severe economic losses in the chicken-farming industry.
Jung Seok Lee +8 more
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Scientific Reports, 2022 Bacteriophage endolysins degrade the bacterial cell wall and are therefore considered promising antimicrobial alternatives to fight pathogens resistant to conventional antibiotics. Gram-positive bacteria are usually considered easy targets to exogenously
Ana Gouveia +5 more
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Bacteriophage Endolysins as Novel Antimicrobials [PDF]
Future Microbiology, 2012 Endolysins are enzymes used by bacteriophages at the end of their replication cycle to degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release of progeny virions. Due to the absence of an outer membrane in the Gram-positive bacterial cell wall, endolysins can access the peptidoglycan and destroy these organisms ...
Schmelcher M, Donovan DM, Loessner MJ
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AMB Express, 2019 Drug-resistant bacteria are a serious threat to global public health. Gram-positive bacterial endolysin preparations have been successfully used to fight Gram-positive bacteria as a novel antimicrobial replacement strategy.
Guangmou Yan +8 more
doaj +1 more source
Scientific Reports, 2023 The bacteriophage CAP 10-3 forming plaques against Cutibacterium acnes which causes skin acne was previously isolated from human skin acne lesion. Incomplete whole genome sequence (WGS) of the bacteriophage CAP 10-3 was obtained and it had 29,643 bp long
Ja-I Kim +2 more
doaj +1 more source
Bacteriophage Endolysins and their Applications
Science Progress, 2016 Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degrade specific bonds within the bacterial cell wall. These enzymes represent a novel class of antibacterial agents against infectious pathogens, especially in light of multidrug-resistant bacteria, which have made antibiotic therapy increasingly redundant.
Jude, Ajuebor +5 more
openaire +2 more sources
Potential of a novel and thermostable recombinant phage endolysin of Escherichia phage KW1E_UTAR against Shigella spp. [PDF]
E3S Web of ConferencesShigella causes millions of cases and hundreds of thousands of deaths annually, mainly affecting children in impoverished countries. Shigellosis outbreaks have been linked to waterborne transmission, and chlorination is commonly used to disinfect water ...
Selvam Dharshini +2 more
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Endolysins of bacteriophage vB_Sal-S-S10 can naturally lyse Salmonella enteritidis
BMC Veterinary Research, 2022 Background The holin-endolysin lysis system plays an essential role in the phage life cycle. Endolysins are promising alternatives to antibiotics, and have been successfully used against Gram-positive bacteria.
Xinrui Wang +5 more
doaj +1 more source
The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor.
PLoS Pathogens, 2014 The bacteriophage ΦCD27 is capable of lysing Clostridium difficile, a pathogenic bacterium that is a major cause for nosocomial infection. A recombinant CD27L endolysin lyses C. difficile in vitro, and represents a promising alternative as a bactericide.
Matthew Dunne +9 more
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