Results 11 to 20 of about 208,461 (352)

Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention

Biomolecules & Biomedicine, 2022
Endometrial cancer is the second gynecological cancer with the highest global incidence. Among many associated risk factors, metabolic syndrome is an important and preventable one.
Alejandra Rocío Pérez-Martín, Denisse Castro-Eguiluz , Lucely Cetina-Pérez, Yadira Velasco-Torres, Antonio Bahena-González, Edgar Montes-Servín, Ernesto González-Ibarra, Raquel Espinosa-Romero, Dolores Gallardo-Rincón   +8 more
doaj   +1 more source

Clinical Benefits of Olaparib in Mexican Ovarian Cancer Patients With Founder Mutation BRCA1-Del ex9-12

Frontiers in Genetics, 2022
Background: Ovarian cancer (OC) is gynecologic cancer with the highest mortality rate. It is estimated that 13–17% of ovarian cancers are due to heritable mutations in BRCA1 and BRCA2.
Dolores Gallardo-Rincón, Dolores Gallardo-Rincón, Edgar Montes-Servín, Gabriela Alamilla-García, Gabriela Alamilla-García, Elizabeth Montes-Servín, Antonio Bahena-González, Antonio Bahena-González, Lucely Cetina-Pérez, Lucely Cetina-Pérez, Flavia Morales Vásquez, Claudia Cano-Blanco, Jaime Coronel-Martínez, Ernesto González-Ibarra, Raquel Espinosa-Romero, Raquel Espinosa-Romero, Rosa María Alvarez-Gómez, Rosa María Alvarez-Gómez, Abraham Pedroza-Torres, Abraham Pedroza-Torres, Denisse Castro-Eguiluz, Denisse Castro-Eguiluz   +21 more
doaj   +1 more source

Risk of Endometrial Cancer and Frequencies of Invasive Endometrial Procedures in Young Breast Cancer Survivors Treated With Tamoxifen: A Nationwide Study

Frontiers in Oncology, 2021
BackgroundAlthough the guidelines recommend gynecological assessment and close monitoring for symptoms of endometrial cancer in postmenopausal breast cancer survivors taking tamoxifen (TAM), the risk of endometrial cancer in young breast cancer survivors
Soojeong Choi, Young Jae Lee, Jae Ho Jeong, Jinhong Jung, Jong Won Lee, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Sei Hyun Ahn, Yura Lee, Yura Lee, Il Yong Chung   +11 more
doaj   +1 more source

Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition

npj Precision Oncology, 2023
Endometrial cancer (EC) patients with metastatic/recurrent disease have limited treatment options and poor survival outcomes. Recently, we discovered the FGFR2c splice isoform is associated with poor prognosis in EC patients.
Asmerom T. Sengal, Vanessa Bonazzi, Deborah Smith, Cristian P. Moiola, Rohan Lourie, Rebecca Rogers, Eva Colas, Antonio Gil-Moreno, Sophia Frentzas, Naven Chetty, Lewis Perrin, Pamela M. Pollock   +11 more
doaj   +1 more source

Clinicopathological and ultrasound features of endometrial cancer in postmenopausal women: a retrospective study in a single institute in South Korea

The Pan African Medical Journal, 2021
INTRODUCTION: Endometrial cancer is the most common type of cancer in the female genital tract. Most patients are diagnosed during postmenopausal periods. To investigate the demographic characteristics as well as cutoff value of endometrial thickness and
Hyen Chul Jo, Jong Chul Baek, Seon Mi Lee, Ji Eun Park, In Ae Cho, Joo Hyun Sung   +5 more
doaj   +1 more source

Endometrial Cancer Arising in Adenomyosis That Could Not Be Diagnosed by Endometrial Biopsy: A Case Report [PDF]

, 2022
Uterine adenomyosis is an estrogen-dependent tumor and one of the most common benign diseases in sexually mature women. The frequency of endometrial cancer associated with adenomyosis has been reported to be 18%–66%. On the other hand, endometrial cancer
Chikumi, Jun, Harada, Tasuku, Komatsu, Hiroaki, Kudoh, Akiko, Nakaso, Takaya, Oishi, Tetsuro, Sato, Shinya, Sawada, Mayumi, Taniguchi, Fuminori   +8 more
core   +1 more source

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin [PDF]

, 2020
High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to
Crosbie, EJ, Finegan, KG, Kitson, S, Latif, A, Lisanti, MP, Marshall, K, McVey, R, Sivalingam, VN, Sotgia, F, Stratford, IJ   +9 more
core   +2 more sources

PDIA6, which is regulated by TRPM2-AS/miR-424-5p axis, promotes endometrial cancer progression via TGF-beta pathway

Cell Death and Disease, 2023
PDIA6 have been reported to be involved in a variety of cancers, however, the underlying role in endometrial cancer is still unclear. In this study, we aimed to study the function of PDIA6 in endometrial cancer.
Pengling Wang, Tianli Zhang, Nan Jiang, Kun Wang, Liping Feng, Ting Liu, Xingsheng Yang   +6 more
doaj   +1 more source

Pre-eclampsia during pregnancy and risk of endometrial cancer: a systematic review and meta-analysis

BMC Women's Health, 2023
Background Pre-eclampsia may be associated with the development of endometrial cancer; however, previous findings have been conflicting. Objectives To investigate if pre-eclampsia is associated with an increased risk of endometrial cancer.
H Jordao, K Herink, Eastwood KA, L McVicker, C Kearns, ÚC McMenamin   +5 more
doaj   +1 more source

Association between diabetes, diabetes treatment and risk of developing endometrial cancer. [PDF]

, 2014
BackgroundA growing body of evidence suggests that diabetes is a risk factor for endometrial cancer incidence. However, most of these studies used case-control study designs and did not adjust for obesity, an established risk factor for endometrial ...
Beresford, S, Chen, C, Chlebowski, R, Garcia, L, Kuller, L, Luo, J, Margolis, KL, Regier, M, Wactawski-Wende, J   +8 more
core   +2 more sources