Results 11 to 20 of about 141,167 (306)

Endometrial cancer and oral contraceptives: an individual participant meta-analysis of 27 276 women with endometrial cancer from 36 epidemiological studies [PDF]

, 2015
Background Oral contraceptives are known to reduce the incidence rate of endometrial cancer, but it is uncertain how long this effect lasts after use ceases, or whether it is modified by other factors.
Collaborative Group On Epidemiological Studies On Endometrial Cancer
core   +5 more sources

Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition

npj Precision Oncology, 2023
Endometrial cancer (EC) patients with metastatic/recurrent disease have limited treatment options and poor survival outcomes. Recently, we discovered the FGFR2c splice isoform is associated with poor prognosis in EC patients.
Asmerom T. Sengal, Vanessa Bonazzi, Deborah Smith, Cristian P. Moiola, Rohan Lourie, Rebecca Rogers, Eva Colas, Antonio Gil-Moreno, Sophia Frentzas, Naven Chetty, Lewis Perrin, Pamela M. Pollock   +11 more
doaj   +1 more source

Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels

iScience, 2023
Summary: To detect novel endometrial cancer risk variants, we leveraged information from endometrial cancer risk factors in a multi-trait GWAS analysis.
Xuemin Wang, Pik Fang Kho, Dhanya Ramachandran, Cemsel Bafligil, Frederic Amant, Ellen L. Goode, Rodney J. Scott, Ian Tomlinson, D. Gareth Evans, Emma J. Crosbie, Thilo Dörk, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara   +13 more
doaj   +1 more source

Clinicopathological and ultrasound features of endometrial cancer in postmenopausal women: a retrospective study in a single institute in South Korea

The Pan African Medical Journal, 2021
INTRODUCTION: Endometrial cancer is the most common type of cancer in the female genital tract. Most patients are diagnosed during postmenopausal periods. To investigate the demographic characteristics as well as cutoff value of endometrial thickness and
Hyen Chul Jo, Jong Chul Baek, Seon Mi Lee, Ji Eun Park, In Ae Cho, Joo Hyun Sung   +5 more
doaj   +1 more source

Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers [PDF]

, 2021
BACKGROUND: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively ...
Permuth, JB, Brenton, JD, Kjaer, SK, Szafron, LM, McAlpine, JN, McNeish, IA, Killeen, JL, May, T, Carney, ME, Durst, M, Glasspool, R, Olsson, H, Webb, PM, Palli, D, Cai, H, DeFazio, A, Aben, KKH, Edwards, DV, Giles, GG, McGuire, V, Liang, D, Hein, A, Annibali, D, Macciotta, A, Thompson, DJ, Karlan, BY, Jensen, A, Moysich, KB, Siddiqui, N, Titus, L, Ferguson, S, Liebrich, C, Odunsi, K, Li, AJ, Attia, J, Konstantopoulou, I, Orsulic, S, Thomsen, LCV, Spiewankiewicz, B, Risch, HA, Swerdlow, AJ, Klapdor, R, Lester, J, Cook, LS, Fasching, PA, Buchanan, DD, Tone, A, Barricarte, A, Mattiello, A, Heitz, F, Sellers, TA, Bodelon, C, De Vivo, I, Høgdall, CK, Bjørge, L, Bützow, R, Bjorge, L, Wu, X, Ewing, A, Fostira, F, Wang, Z, Wu, AH, White, E, Lissowska, J, Rothstein, JH, Scott, RJ, Spurdle, AB, Lu, L, Dunning, AM, Goodman, MT, Jakubowska, A, Podgorska, A, Gaudet, MM, Flanagan, JM, Osorio, A, Gentry-Maharaj, A, Beckmann, MW, Kraft, P, Larson, MC, Turman, C, Modugno, F, Vierkant, RA, Burghaus, S, Riggan, MJ, Rebbeck, TR, OPAL Study Group,, Holliday, EG, Harter, P, Pearce, CL, Park-Simon, T-W, Bischof, K, Senz, J, Lele, S, Friedenreich, CM, Runnebaum, IB, Huzarski, T, Thompson, PJ, Bermisheva, M, Chen, XQ, Glubb, DM, Amant, F, Chanock, SJ, Koti, M, Bruinsma, F, Cunningham, JM, Ramus, SJ, Aben, KK, Dork, T, Jones, ME, Konopka, B, Nevanlinna, H, Sutphen, R, Sieh, W, Alsulimani, A, Khusnutdinova, E, Pejovic, T, Yannoukakos, D, Menon, U, Edwards, RP, Chen, Z, Hillemanns, P, Winham, SJ, Köbel, M, Doherty, JA, Gao, B, Karnezis, A, Chen, X, Kopperud, RK, Le Marchand, L, Wang-Gohrke, S, Lu, KH, Fountzilas, G, Gronwald, J, Teo, SH, Setiawan, VW, Huntsman, DG, Ekici, AB, du Bois, A, Chen, C, Brinton, LA, Hildebrandt, MAT, Kelley, JL, Edwards, T, Gawełko, J, Velez Edwards, D, Bernardini, MQ, Lipworth, L, Brand, AH, Tumino, R, Berchuck, A, Lambrechts, D, Kupryjanczyk, J, Vanderstichele, A, Vergote, I, Whittemore, AS, Høgdall, E, Harris, HR, O'Mara, TA, AOCS Group,   +158 more
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Classification of Endometrial Cancer [PDF]

, 2020
Endometrial cancer is the most common malignancy of the female genital tract in the more developed regions of the world [1]. Stage of disease, i.e., the extent of tumor spread at the time of presentation, is the most significant prognostic parameter.
Åvall-Lundqvist, Elisabeth,
core   +1 more source

Endometrial cancer

Cell and Tissue Research, 2005
Endometrial cancer is the most common gynaecological malignancy in the developed world. The majority of cases can be divided into two broad categories based on clinico-pathological and molecular characteristics; Type I oestrogen-dependent with endometrioid morphology and Type II non-oestrogen-dependent with serous papillary or clear cell morphology. As
Andrew J, Ryan, Beatrice, Susil, Thomas W, Jobling, Martin K, Oehler   +3 more
openaire   +6 more sources

Pre-eclampsia during pregnancy and risk of endometrial cancer: a systematic review and meta-analysis

BMC Women's Health, 2023
Background Pre-eclampsia may be associated with the development of endometrial cancer; however, previous findings have been conflicting. Objectives To investigate if pre-eclampsia is associated with an increased risk of endometrial cancer.
H Jordao, K Herink, Eastwood KA, L McVicker, C Kearns, ÚC McMenamin   +5 more
doaj   +1 more source

Mutations and amplification of oncogenes in endometrial cancer [PDF]

, 1999
Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
Niederacher, Dieter, Cho, Yong-Jig, An, Han-Xiang, Beckmann, Matthias W., Hantschmann, Peer, Bender, Hans G.   +5 more
core   +1 more source

MicroRNA-135a promotes proliferation, migration, invasion and induces chemoresistance of endometrial cancer cells

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2020
Aims: MicroRNAs play essential roles in tumorigenesis and progression in various cancers including endometrial cancer. Here we assessed the role of miR-135a on proliferation, chemosensitivity, migration and invasion of endometrial cancer cells.
Jiping Wang, Li Zhang, Wenyan Jiang, Rongkui Zhang, Bei Zhang, Aidaeraili Silayiding, Xiumei Duan   +6 more
doaj   +1 more source