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Endometrial cancer is the most common gynaecological cancer in high income countries and its incidence is rising globally. Although an ageing population and fewer benign hysterectomies have contributed to this trend, the growing prevalence of obesity is the major underlying cause.
Crosbie, Emma J +5 more
openaire +5 more sources
Endometrial cancer is the most common gynecological malignancy in well-developed countries. Biologically and clinicopathologically, endometrial carcinomas are divided into two types: type 1 or estrogen-dependent carcinomas and type 2 or estrogen-independent carcinomas.
Horta, Mariana, Cunha, Teresa Margarida
openaire +5 more sources
Despite the questions and barriers, the incorporation of molecular therapy into treatment regimens in endometrial cancer is an exciting area of investigation with the potential to improve outcomes. Outside of the development of a reliable screening test for endometrial cancer, converting the disease to a chronic state and improving progression-free ...
Kimberly K, Leslie +5 more
openaire +4 more sources
Endometrial cancer is the most common gynaecological malignancy in the developed world. The majority of cases can be divided into two broad categories based on clinico-pathological and molecular characteristics; Type I oestrogen-dependent with endometrioid morphology and Type II non-oestrogen-dependent with serous papillary or clear cell morphology. As
Andrew J, Ryan +3 more
openaire +6 more sources
Pre-eclampsia during pregnancy and risk of endometrial cancer: a systematic review and meta-analysis
Background Pre-eclampsia may be associated with the development of endometrial cancer; however, previous findings have been conflicting. Objectives To investigate if pre-eclampsia is associated with an increased risk of endometrial cancer.
H Jordao +5 more
doaj +1 more source
Aims: MicroRNAs play essential roles in tumorigenesis and progression in various cancers including endometrial cancer. Here we assessed the role of miR-135a on proliferation, chemosensitivity, migration and invasion of endometrial cancer cells.
Jiping Wang +6 more
doaj +1 more source
Background Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-
Yue Chang +5 more
doaj +1 more source
PDIA6 have been reported to be involved in a variety of cancers, however, the underlying role in endometrial cancer is still unclear. In this study, we aimed to study the function of PDIA6 in endometrial cancer.
Pengling Wang +6 more
doaj +1 more source
Long non-coding RNAs (lncRNAs) are implicated in the initiation and progression of a variety of tumors, including endometrial cancer. However, the mechanisms of lncRNA in endometrial cancer formation and progression remain largely unknown. In this study,
Lee Kyung Kim +5 more
doaj +1 more source
Background Endometriosis is assumed to be involved in ovarian cancer development, which is called endometriosis-associated ovarian cancer (EAOC). Uterine endometrial cells may be the cell of origin of EAOC. Accumulated carcinogenic changes in the uterine
Aya Ishizaka +13 more
doaj +1 more source

