Results 21 to 30 of about 234,996 (348)

Risk of Endometrial Cancer and Frequencies of Invasive Endometrial Procedures in Young Breast Cancer Survivors Treated With Tamoxifen: A Nationwide Study

Frontiers in Oncology, 2021
BackgroundAlthough the guidelines recommend gynecological assessment and close monitoring for symptoms of endometrial cancer in postmenopausal breast cancer survivors taking tamoxifen (TAM), the risk of endometrial cancer in young breast cancer survivors
Soojeong Choi, Young Jae Lee, Jae Ho Jeong, Jinhong Jung, Jong Won Lee, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Sei Hyun Ahn, Yura Lee, Yura Lee, Il Yong Chung   +11 more
doaj   +1 more source

Pathology findings among women with alterations in uterine bleeding patterns in cameroon

Gynecologic Oncology Reports, 2021
Purpose: Endometrial cancer is on the rise in high-income countries but it has not been adequately studied in low-and-middle income countries especially in sub-Saharan Africa (SSA), likely due to scarce pathology facilities. The purpose of this study was
Simon M. Manga, Yuanfan Ye, Jeff M. Szychowski, Kathleen L. Nulah, Calvin Ngalla, Kaitlyn Kincaid, Teresa K.L. Boitano, Alan T. Tita, Isabel Scarinci, Warner K. Huh, Zacharie Sando, Margaret I. Liang   +11 more
doaj   +1 more source

Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition

npj Precision Oncology, 2023
Endometrial cancer (EC) patients with metastatic/recurrent disease have limited treatment options and poor survival outcomes. Recently, we discovered the FGFR2c splice isoform is associated with poor prognosis in EC patients.
Asmerom T. Sengal, Vanessa Bonazzi, Deborah Smith, Cristian P. Moiola, Rohan Lourie, Rebecca Rogers, Eva Colas, Antonio Gil-Moreno, Sophia Frentzas, Naven Chetty, Lewis Perrin, Pamela M. Pollock   +11 more
doaj   +1 more source

Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels

iScience, 2023
Summary: To detect novel endometrial cancer risk variants, we leveraged information from endometrial cancer risk factors in a multi-trait GWAS analysis.
Xuemin Wang, Pik Fang Kho, Dhanya Ramachandran, Cemsel Bafligil, Frederic Amant, Ellen L. Goode, Rodney J. Scott, Ian Tomlinson, D. Gareth Evans, Emma J. Crosbie, Thilo Dörk, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara   +13 more
doaj   +1 more source

Clinicopathological and ultrasound features of endometrial cancer in postmenopausal women: a retrospective study in a single institute in South Korea

The Pan African Medical Journal, 2021
INTRODUCTION: Endometrial cancer is the most common type of cancer in the female genital tract. Most patients are diagnosed during postmenopausal periods. To investigate the demographic characteristics as well as cutoff value of endometrial thickness and
Hyen Chul Jo, Jong Chul Baek, Seon Mi Lee, Ji Eun Park, In Ae Cho, Joo Hyun Sung   +5 more
doaj   +1 more source

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin [PDF]

, 2020
High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to
Crosbie, EJ, Finegan, KG, Kitson, S, Latif, A, Lisanti, MP, Marshall, K, McVey, R, Sivalingam, VN, Sotgia, F, Stratford, IJ   +9 more
core   +2 more sources

Pre-eclampsia during pregnancy and risk of endometrial cancer: a systematic review and meta-analysis

BMC Women's Health, 2023
Background Pre-eclampsia may be associated with the development of endometrial cancer; however, previous findings have been conflicting. Objectives To investigate if pre-eclampsia is associated with an increased risk of endometrial cancer.
H Jordao, K Herink, Eastwood KA, L McVicker, C Kearns, ÚC McMenamin   +5 more
doaj   +1 more source

MicroRNA-135a promotes proliferation, migration, invasion and induces chemoresistance of endometrial cancer cells

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2020
Aims: MicroRNAs play essential roles in tumorigenesis and progression in various cancers including endometrial cancer. Here we assessed the role of miR-135a on proliferation, chemosensitivity, migration and invasion of endometrial cancer cells.
Jiping Wang, Li Zhang, Wenyan Jiang, Rongkui Zhang, Bei Zhang, Aidaeraili Silayiding, Xiumei Duan   +6 more
doaj   +1 more source

LncRNA SNHG4 Modulates EMT Signal and Antitumor Effects in Endometrial Cancer through Transcription Factor SP-1

Biomedicines, 2023
Long non-coding RNAs (lncRNAs) are implicated in the initiation and progression of a variety of tumors, including endometrial cancer. However, the mechanisms of lncRNA in endometrial cancer formation and progression remain largely unknown. In this study,
Lee Kyung Kim, Sun-Ae Park, Eun Ji Nam, Young Tae Kim, Tae-Hwe Heo, Hee Jung Kim   +5 more
doaj   +1 more source

Metapristone (RU486-derivative) inhibits endometrial cancer cell progress through regulating miR-492/Klf5/Nrf1 axis

Cancer Cell International, 2021
Background Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-
Yue Chang, Min Hao, Ru Jia, Yihui Zhao, Yixuan Cai, Yun Liu   +5 more
doaj   +1 more source